Family-based designs for genome-wide association studies

	Family-based designs for genome-wide association studies
	Ott, Jurg 1; Kamatani, Yoichiro 2; Lathrop, Mark 2,3; Ott, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Association mapping has successfully identified common SNPs associated with many diseases. However, the inability of this class of variation to account for most of the supposed heritability has led to a renewed interest in methods - primarily linkage analysis - to detect rare variants. Family designs allow for control of population stratification, investigations of questions such as parent-of-origin effects and other applications that are imperfectly or not readily addressed in case-control association studies. This article guides readers through the interface between linkage and association analysis, reviews the new methodologies and provides useful guidelines for applications. Just as effective SNP-genotyping tools helped to realize the potential of association studies, next-generation sequencing tools will benefit genetic studies by improving the power of family-based approaches.
学科领域	Social Psychology
	2011-07-01
语种	英语
发表期刊	NATURE REVIEWS GENETICS
ISSN	1471-0056
卷号	12 期号:7 页码:465-474
期刊论文类型	Review
收录类别	SCI
项目简介	We are grateful to J. Terwilliger for providing us with unpublished results on his pseudomarker method. Our work was partially supported by the National Natural Science Foundation of China (NSFC) grant no. 30730057 to J.O.
WOS记录号	WOS:000292814500009
资助机构	National Natural Science Foundation of China (NSFC) [30730057]
引用统计	被引频次：186[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11524
专题	中国科学院心理健康重点实验室
通讯作者	Ott, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Ctr Etud Polymorphisme Humain, Fdn Jean Dausset, F-75012 Paris, France 3.CEA IC Ctr Natl Genotypage, F-91057 Evry, France
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Ott, Jurg,Kamatani, Yoichiro,Lathrop, Mark,et al. Family-based designs for genome-wide association studies[J]. NATURE REVIEWS GENETICS,2011,12(7):465-474.
APA	Ott, Jurg,Kamatani, Yoichiro,Lathrop, Mark,&Ott, J .(2011).Family-based designs for genome-wide association studies.NATURE REVIEWS GENETICS,12(7),465-474.
MLA	Ott, Jurg,et al."Family-based designs for genome-wide association studies".NATURE REVIEWS GENETICS 12.7(2011):465-474.

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