PSYCH OpenIR  > 中国科学院心理健康重点实验室
Family-based designs for genome-wide association studies
Ott, Jurg1; Kamatani, Yoichiro2; Lathrop, Mark2,3; Ott, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
2011-07-01
发表期刊NATURE REVIEWS GENETICS
ISSN1471-0056
文章类型Review
卷号12期号:7页码:465-474
产权排序1
摘要Association mapping has successfully identified common SNPs associated with many diseases. However, the inability of this class of variation to account for most of the supposed heritability has led to a renewed interest in methods - primarily linkage analysis - to detect rare variants. Family designs allow for control of population stratification, investigations of questions such as parent-of-origin effects and other applications that are imperfectly or not readily addressed in case-control association studies. This article guides readers through the interface between linkage and association analysis, reviews the new methodologies and provides useful guidelines for applications. Just as effective SNP-genotyping tools helped to realize the potential of association studies, next-generation sequencing tools will benefit genetic studies by improving the power of family-based approaches.
学科领域Social Psychology
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China (NSFC) [30730057]
项目简介We are grateful to J. Terwilliger for providing us with unpublished results on his pseudomarker method. Our work was partially supported by the National Natural Science Foundation of China (NSFC) grant no. 30730057 to J.O.
WOS记录号WOS:000292814500009
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11524
专题中国科学院心理健康重点实验室
通讯作者Ott, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Ctr Etud Polymorphisme Humain, Fdn Jean Dausset, F-75012 Paris, France
3.CEA IC Ctr Natl Genotypage, F-91057 Evry, France
推荐引用方式
GB/T 7714
Ott, Jurg,Kamatani, Yoichiro,Lathrop, Mark,et al. Family-based designs for genome-wide association studies[J]. NATURE REVIEWS GENETICS,2011,12(7):465-474.
APA Ott, Jurg,Kamatani, Yoichiro,Lathrop, Mark,&Ott, J .(2011).Family-based designs for genome-wide association studies.NATURE REVIEWS GENETICS,12(7),465-474.
MLA Ott, Jurg,et al."Family-based designs for genome-wide association studies".NATURE REVIEWS GENETICS 12.7(2011):465-474.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000292814500009.p(546KB) 开放获取Apache License请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ott, Jurg]的文章
[Kamatani, Yoichiro]的文章
[Lathrop, Mark]的文章
百度学术
百度学术中相似的文章
[Ott, Jurg]的文章
[Kamatani, Yoichiro]的文章
[Lathrop, Mark]的文章
必应学术
必应学术中相似的文章
[Ott, Jurg]的文章
[Kamatani, Yoichiro]的文章
[Lathrop, Mark]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。