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Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats
Xu, W.1,2; Li, Y. H.1; Tan, B. P.1; Luo, X. J.1; Xiao, L.1; Zheng, X. G.1; Yang, X. Y.1; Sui, N.1; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, POB 1603, Beijing 100101, Peoples R China.
2012
发表期刊PHYSIOLOGICAL RESEARCH
ISSN0862-8408
文章类型Article
卷号61期号:4页码:437-442
产权排序1
摘要The negative affective state of opiate abstinence plays an important role in craving and relapse to compulsive drug use. The dopamine system participates in the reward effects of opiate use and the aversive effect of opiate abstinence. The amygdala is an essential neural substrate for associative learning of emotion. To establish a model of conditioned place aversion (CPA) in morphine-treated rats, we used different visual and tactual cues as conditioned stimuli (CS) within a conditioning apparatus. An injection of naloxone served as the unconditioned stimulus (US). The 6-hydroxydopamine (6-OHDA) lesion technique was used to investigate the effects of the dopaminergic system of the central nucleus of the amygdala (CeA) on naloxone-induced CPA. Rats were rendered physically dependent via administration of increasing doses of morphine delivered via intraperitoneal injection. Doses increased by 20% each day for 14 days, starting from an initial dose of 6 mg/kg. All rats also received a low dose of naloxone (0.1 mg/kg) by injection 4 hours after morphine treatment on days 11 and 13 to induce CPA in a biased two-compartment conditioned place apparatus. Morphine-dependent rats with sham lesions were found to develop significant CPA after naloxone treatment. Bilateral 6-OHDA lesions of the CeA impaired the acquisition of CPA but had no effect on locomotor activity. These results suggest that the dopaminergic system of the CeA plays an important role in the negative affective state of opiate abstinence.
关键词Conditioned place aversion Central nucleus of amygdala Dopamine 6-OHDA
学科领域Medical Psychology
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收录类别SCI
语种英语
项目资助者National Basic Research Program [2009CB522002] ; Chinese Academy of Sciences [KSCX2-EW-R-12, KSCX2-EW-Q-18] ; National Natural Science Foundation [31070911]
项目简介This work was supported by the National Basic Research Program (2009CB522002), the Chinese Academy of Sciences (KSCX2-EW-R-12, KSCX2-EW-Q-18), and the National Natural Science Foundation (31070911)
WOS记录号WOS:000309194600013
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11865
专题中国科学院心理健康重点实验室
通讯作者Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, POB 1603, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, Beijing 100101, Peoples R China
2.Beijing Univ Chem Technol, Sch Humanities & Law, Mental Hlth Educ Res Ctr, Beijing, Peoples R China
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GB/T 7714
Xu, W.,Li, Y. H.,Tan, B. P.,et al. Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats[J]. PHYSIOLOGICAL RESEARCH,2012,61(4):437-442.
APA Xu, W..,Li, Y. H..,Tan, B. P..,Luo, X. J..,Xiao, L..,...&Sui, N .(2012).Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats.PHYSIOLOGICAL RESEARCH,61(4),437-442.
MLA Xu, W.,et al."Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats".PHYSIOLOGICAL RESEARCH 61.4(2012):437-442.
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