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Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression
Chen, J.1; Li, X.1; McGue, M.2; Li, X (reprint author), 4A Datun Rd, Beijing 100101, Peoples R China.
2012-11-01
发表期刊GENES BRAIN AND BEHAVIOR
ISSN1601-1848
文章类型Article
卷号11期号:8页码:958-965
产权排序1
摘要There is a strong etiological link between brain-derived neurotrophic factor and depression, but the neurocellular mechanisms and gene-environment interactions remain obscure. This study investigated whether one functional polymorphism in the brain-derived neurotrophic factor gene (BDNF Val66Met) modulates the influence of stressful life events on adolescent depressive symptoms. A total of 780 pairs of ethnic Han Chinese adolescent twins, 11-17 years of age, were randomly assigned to one of two subgroups (twin1 and twin2). All subjects were genotyped as Val/Val, Val/Met or Met/Met, and assessed for depressive symptoms using the Children's Depression Inventory. The level of environmental stress was estimated by the frequency of stressful life events using the Life Events Checklist. The frequency of stressful life events was significantly correlated with depressive symptoms (twin1: beta = 0.21, P = 0.01; twin2: beta = 0.27, P < 0.01), but there was no significant main effect of the BDNF Val66Met genotype on depressive symptoms. In both subgroups, however, the interaction between the BDNF Val66Met genotype and stressful life event frequency was significant (twin1: beta = 0.19, P = 0.01; twin2: beta = 0.15, P = 0.04); individuals with one or two Val alleles demonstrated a greater susceptibility to both the detrimental effects of higher stress and the beneficial effects of lower stress compared to the Met/Met genotype. These findings support the 'differential-susceptibility' hypothesis, whereby the BDNF Val allele modulates the influence of environmental stress on depression by enhancing the neuroplastic response to all life events.
关键词Adolescence BDNF Val66Met polymorphism depressive symptoms gene-environment interaction stressful life events
学科领域Developmental Psychology,Emotional Psychology
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收录类别SCI
语种英语
项目资助者Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Chinese Academy of Sciences [KSCX2-EW-J-8] ; Institute of Psychology, Chinese Academy of Science [Y0CX351S01] ; National Natural Science Foundation of China [31170993, 91132728]
项目简介This study was supported by the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8), Funds for Young Scholars of the Institute of Psychology, Chinese Academy of Science (Y0CX351S01), and the National Natural Science Foundation of China (31170993 and 91132728). The original Principal Investigator, Dr Xiaojia Ge, passed away during this study. The authors dedicate this paper to the memory of Dr Xiaojia Ge for his great contribution in founding the BeTwiSt. We are grateful to participating twin families and schools. No author has a conflict of interest to declare.
WOS记录号WOS:000313994300008
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11869
专题中国科学院心理健康重点实验室
通讯作者Li, X (reprint author), 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA
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Chen, J.,Li, X.,McGue, M.,et al. Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression[J]. GENES BRAIN AND BEHAVIOR,2012,11(8):958-965.
APA Chen, J.,Li, X.,McGue, M.,&Li, X .(2012).Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.GENES BRAIN AND BEHAVIOR,11(8),958-965.
MLA Chen, J.,et al."Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression".GENES BRAIN AND BEHAVIOR 11.8(2012):958-965.
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