Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes

	Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes
	Mcalonan, Grainne M.1,2; Yu, Kevin K.1; Chan, Raymond C. K.3 ; Chua, Siew E.1,2; Cheung, Charlton 1; Mcalonan, GM (reprint author), Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
心理所单位排序	3
摘要	The term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions.
关键词	autism schizophrenia bipolar grey matter ALE meta-analysis
学科领域	Cognitive Neuroscience
	2011-11-01
语种	英语
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	56 期号:32 页码:3376-3381
期刊论文类型	Review
URL	查看原文
收录类别	SCI
项目简介	The Autism Research Group in the Department of Psychiatry University of Hong Kong is grateful for donation funding from ING Asia/Pacific.
WOS记录号	WOS:000296641800004
资助机构	ING Asia/Pacific
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/11877
专题	脑与认知科学国家重点实验室
通讯作者	Mcalonan, GM (reprint author), Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
作者单位	1.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China 3.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Mcalonan, Grainne M.,Yu, Kevin K.,Chan, Raymond C. K.,et al. Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3376-3381.
APA	Mcalonan, Grainne M.,Yu, Kevin K.,Chan, Raymond C. K.,Chua, Siew E.,Cheung, Charlton,&Mcalonan, GM .(2011).Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes.CHINESE SCIENCE BULLETIN,56(32),3376-3381.
MLA	Mcalonan, Grainne M.,et al."Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes".CHINESE SCIENCE BULLETIN 56.32(2011):3376-3381.

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