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Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes
Mcalonan, Grainne M.1,2; Yu, Kevin K.1; Chan, Raymond C. K.3; Chua, Siew E.1,2; Cheung, Charlton1; Mcalonan, GM (reprint author), Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
2011-11-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
SubtypeReview
Volume56Issue:32Pages:3376-3381
Contribution Rank3
AbstractThe term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions.
Keywordautism schizophrenia bipolar grey matter ALE meta-analysis
Subject AreaCognitive Neuroscience
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Indexed BySCI
Language英语
Funding OrganizationING Asia/Pacific
Project Intro.The Autism Research Group in the Department of Psychiatry University of Hong Kong is grateful for donation funding from ING Asia/Pacific.
WOS IDWOS:000296641800004
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11877
Collection脑与认知科学国家重点实验室
Corresponding AuthorMcalonan, GM (reprint author), Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
Affiliation1.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China
3.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
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GB/T 7714
Mcalonan, Grainne M.,Yu, Kevin K.,Chan, Raymond C. K.,et al. Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3376-3381.
APA Mcalonan, Grainne M.,Yu, Kevin K.,Chan, Raymond C. K.,Chua, Siew E.,Cheung, Charlton,&Mcalonan, GM .(2011).Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes.CHINESE SCIENCE BULLETIN,56(32),3376-3381.
MLA Mcalonan, Grainne M.,et al."Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes".CHINESE SCIENCE BULLETIN 56.32(2011):3376-3381.
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