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Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes
Mcalonan, Grainne M.1,2; Yu, Kevin K.1; Chan, Raymond C. K.3; Chua, Siew E.1,2; Cheung, Charlton1; Mcalonan, GM (reprint author), Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
2011-11-01
发表期刊CHINESE SCIENCE BULLETIN
ISSN1001-6538
文章类型Review
卷号56期号:32页码:3376-3381
产权排序3
摘要The term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions.
关键词autism schizophrenia bipolar grey matter ALE meta-analysis
学科领域Cognitive Neuroscience
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收录类别SCI
语种英语
项目资助者ING Asia/Pacific
项目简介The Autism Research Group in the Department of Psychiatry University of Hong Kong is grateful for donation funding from ING Asia/Pacific.
WOS记录号WOS:000296641800004
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11877
专题脑与认知科学国家重点实验室
通讯作者Mcalonan, GM (reprint author), Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
作者单位1.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China
3.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
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Mcalonan, Grainne M.,Yu, Kevin K.,Chan, Raymond C. K.,et al. Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3376-3381.
APA Mcalonan, Grainne M.,Yu, Kevin K.,Chan, Raymond C. K.,Chua, Siew E.,Cheung, Charlton,&Mcalonan, GM .(2011).Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes.CHINESE SCIENCE BULLETIN,56(32),3376-3381.
MLA Mcalonan, Grainne M.,et al."Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes".CHINESE SCIENCE BULLETIN 56.32(2011):3376-3381.
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