Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats

	Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats
	Han, Xiao 2; Wang, Weiwen3 ; Shao, Feng 2; Li, Nanxin 1,2; Li, NX (reprint author), Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychol, 34 Pk St, New Haven, CT 06508 USA.
	2011-04-18
发表期刊	BRAIN RESEARCH
ISSN	0006-8993
文章类型	Article
卷号	1385 页码:175-181
产权排序	2
摘要	Isolation rearing induces profound behavioral and neurochemical abnormalities in rodents. However, there is some controversy regarding the effect of isolation rearing on social behaviors and monoamine neurotransmission in mesolimbic and mesocortical areas. In the current study, we aimed to address these issues and demonstrated that isolation rearing from weaning to adulthood resulted in increased playful fighting and social contact behaviors. Isolation-reared rats also manifested increased dopamine and serotonin levels in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) as well as an increase in serotonin turnover in the NAc. This study provides additional evidence that social isolation induces alterations in behavior and in the brain. (C) 2011 Elsevier B.V. All rights reserved.
关键词	Aggression Dopamine Isolation rearing Nucleus accumbens Prefrontal cortex Serotonin Social interaction
学科领域	Physiological Psychology/biological Psychology
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收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China [31070910] ; National Basic Research Program of China (973 Program) [2007CB512306] ; Chinese Academy of Sciences [KSCX2-YW-R-131] ; American Psychological Association ; Institute of Psychology, Chinese Academy of Science [O9KF013001]
项目简介	This work was supported by the National Natural Science Foundation of China (grant No. 31070910), National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), American Psychological Association, and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (O9KF013001).
WOS记录号	WOS:000289810800019
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11879
专题	中国科学院心理健康重点实验室
通讯作者	Li, NX (reprint author), Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychol, 34 Pk St, New Haven, CT 06508 USA.
作者单位	1.Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA 2.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Han, Xiao,Wang, Weiwen,Shao, Feng,et al. Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats[J]. BRAIN RESEARCH,2011,1385:175-181.
APA	Han, Xiao,Wang, Weiwen,Shao, Feng,Li, Nanxin,&Li, NX .(2011).Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats.BRAIN RESEARCH,1385,175-181.
MLA	Han, Xiao,et al."Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats".BRAIN RESEARCH 1385(2011):175-181.

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