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| Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats | |
Han, Xiao2; Wang, Weiwen3 ; Shao, Feng2; Li, Nanxin1,2; Li, NX (reprint author), Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychol, 34 Pk St, New Haven, CT 06508 USA.
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| 心理所单位排序 | 2 |
| 摘要 | Isolation rearing induces profound behavioral and neurochemical abnormalities in rodents. However, there is some controversy regarding the effect of isolation rearing on social behaviors and monoamine neurotransmission in mesolimbic and mesocortical areas. In the current study, we aimed to address these issues and demonstrated that isolation rearing from weaning to adulthood resulted in increased playful fighting and social contact behaviors. Isolation-reared rats also manifested increased dopamine and serotonin levels in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) as well as an increase in serotonin turnover in the NAc. This study provides additional evidence that social isolation induces alterations in behavior and in the brain. (C) 2011 Elsevier B.V. All rights reserved. |
| 关键词 | Aggression Dopamine Isolation rearing Nucleus accumbens Prefrontal cortex Serotonin Social interaction |
| 学科领域 | Physiological Psychology/biological Psychology |
| 2011-04-18 | |
| 语种 | 英语 |
| 发表期刊 | BRAIN RESEARCH
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| ISSN | 0006-8993 |
| 卷号 | 1385页码:175-181 |
| 期刊论文类型 | Article |
| URL | 查看原文 |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Natural Science Foundation of China (grant No. 31070910), National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), American Psychological Association, and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (O9KF013001). |
| WOS记录号 | WOS:000289810800019 |
| 资助机构 | National Natural Science Foundation of China [31070910] ; National Basic Research Program of China (973 Program) [2007CB512306] ; Chinese Academy of Sciences [KSCX2-YW-R-131] ; American Psychological Association ; Institute of Psychology, Chinese Academy of Science [O9KF013001] |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.psych.ac.cn/handle/311026/11879 |
| 专题 | 中国科学院心理健康重点实验室 |
| 通讯作者 | Li, NX (reprint author), Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychol, 34 Pk St, New Haven, CT 06508 USA. |
| 作者单位 | 1.Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA 2.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Xiao,Wang, Weiwen,Shao, Feng,et al. Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats[J]. BRAIN RESEARCH,2011,1385:175-181. |
| APA | Han, Xiao,Wang, Weiwen,Shao, Feng,Li, Nanxin,&Li, NX .(2011).Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats.BRAIN RESEARCH,1385,175-181. |
| MLA | Han, Xiao,et al."Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats".BRAIN RESEARCH 1385(2011):175-181. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS_000289810800019.（426KB） | 开放获取 | Apache License | 浏览 下载 | |||
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