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Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring
Han, Xiao1; Li, Nanxin1,3; Meng, Qingxuan1; Shao, Feng1; Wang, Weiwen2; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
2011
发表期刊NEUROPSYCHOBIOLOGY
ISSN0302-282X
文章类型Article
卷号64期号:1页码:9-14
产权排序2
摘要Maternal immune activation (MIA) produces a variety of behavioral and brain abnormalities in rodent models of several neuropsychiatric disorders. However, it remains controversial whether MIA impairs reversal learning, a basic function of flexibility relevant to those diseases, in offspring. In the present study, we used the Morris water maze to investigate the effects of middle to late gestation stage poly(I:C) challenges on spatial learning and subsequent reversal learning performance in adolescent rats. Maternal poly(I:C) treatment induced deficits in reversal learning without affecting spatial acquisition abilities. In addition, the serum level of the pro-inflammatory cytokine tumor necrosis factor-alpha was increased in MIA rats. This study advances our understanding of how MIA affects adolescent behavior and brain function. Copyright (C) 2011 S. Karger AG, Basel
关键词Maternal immune activation Reversal learning Tumor necrosis factor-alpha Adolescent Schizophrenia
学科领域Physiological Psychology/biological Psychology
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [30670708, 30500158] ; National Basic Research Program of China (973 Program) [2007CB512306] ; Chinese Academy of Sciences [KSCX2-YW-R-131] ; American Psychological Association ; Institute of Psychology, Chinese Academy of Science [O9KF013001]
项目简介This work was supported by the National Natural Science Foundation of China (grant No. 30670708, 30500158), the National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), the American Psychological Association (Scott Mesh Scholarship for Research in Psychology) and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (O9KF013001).
WOS记录号WOS:000291025300002
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11889
专题中国科学院心理健康重点实验室
通讯作者Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06520 USA
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Han, Xiao,Li, Nanxin,Meng, Qingxuan,et al. Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring[J]. NEUROPSYCHOBIOLOGY,2011,64(1):9-14.
APA Han, Xiao,Li, Nanxin,Meng, Qingxuan,Shao, Feng,Wang, Weiwen,&Shao, F .(2011).Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring.NEUROPSYCHOBIOLOGY,64(1),9-14.
MLA Han, Xiao,et al."Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring".NEUROPSYCHOBIOLOGY 64.1(2011):9-14.
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