Institutional Repository of Key Laboratory of Mental Health, CAS
| Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring | |
Han, Xiao1; Li, Nanxin1,3; Meng, Qingxuan1; Shao, Feng1; Wang, Weiwen2 ; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
| |
| 心理所单位排序 | 2 |
| 摘要 | Maternal immune activation (MIA) produces a variety of behavioral and brain abnormalities in rodent models of several neuropsychiatric disorders. However, it remains controversial whether MIA impairs reversal learning, a basic function of flexibility relevant to those diseases, in offspring. In the present study, we used the Morris water maze to investigate the effects of middle to late gestation stage poly(I:C) challenges on spatial learning and subsequent reversal learning performance in adolescent rats. Maternal poly(I:C) treatment induced deficits in reversal learning without affecting spatial acquisition abilities. In addition, the serum level of the pro-inflammatory cytokine tumor necrosis factor-alpha was increased in MIA rats. This study advances our understanding of how MIA affects adolescent behavior and brain function. Copyright (C) 2011 S. Karger AG, Basel |
| 关键词 | Maternal immune activation Reversal learning Tumor necrosis factor-alpha Adolescent Schizophrenia |
| 学科领域 | Physiological Psychology/biological Psychology |
| 2011 | |
| 语种 | 英语 |
| 发表期刊 | NEUROPSYCHOBIOLOGY
 |
| ISSN | 0302-282X |
| 卷号 | 64期号:1页码:9-14 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Natural Science Foundation of China (grant No. 30670708, 30500158), the National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), the American Psychological Association (Scott Mesh Scholarship for Research in Psychology) and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (O9KF013001). |
| WOS记录号 | WOS:000291025300002 |
| 资助机构 | National Natural Science Foundation of China [30670708, 30500158] ; National Basic Research Program of China (973 Program) [2007CB512306] ; Chinese Academy of Sciences [KSCX2-YW-R-131] ; American Psychological Association ; Institute of Psychology, Chinese Academy of Science [O9KF013001] |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/11889 |
| 专题 | 中国科学院心理健康重点实验室 |
| 通讯作者 | Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06520 USA |
| 推荐引用方式 GB/T 7714 | Han, Xiao,Li, Nanxin,Meng, Qingxuan,et al. Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring[J]. NEUROPSYCHOBIOLOGY,2011,64(1):9-14. |
| APA | Han, Xiao,Li, Nanxin,Meng, Qingxuan,Shao, Feng,Wang, Weiwen,&Shao, F .(2011).Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring.NEUROPSYCHOBIOLOGY,64(1),9-14. |
| MLA | Han, Xiao,et al."Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring".NEUROPSYCHOBIOLOGY 64.1(2011):9-14. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS000291025300002.p（118KB） | 限制开放 | Apache License | 请求全文 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论