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Genetic Basis and Neural Mechanism of Autism Spectrum Disorder
Li Jing1,2; Lin Zhu-Mei1,2; Zhu Li-Qi1; Zhu, LQ (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China.
2012-10-01
发表期刊PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN1000-3282
文章类型Article
卷号39期号:10页码:952-961
产权排序1
摘要Autism spectrum disorder (ASD) is a defective mental disease and its core impairments are social function defect, communication defect, restrictive and stereotyped behavior pattern. The paper introduces the genetic basis and neural mechanism of ASD. ASD has high genetic rate, and 5-HT and testosterone of ASD individual are both higher. Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala, cingulate gyrus, the fusiform gyrus, mirror neurons, prefrontal lobe and other brain areas, but it is inconsistent in the discrepancy direction of some areas' activation patterns. In addition, the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection. Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research.
关键词autism spectrum disorder gene brain function brain function connectivity
学科领域Abnormal Psychology
收录类别SCI
语种英语
项目资助者National Basic Research Program of China [2010CB8339004] ; The National Natural Science Foundation of China [30970911]
项目简介This work was supported by grants from National Basic Research Program of China (2010CB8339004) and The National Natural Science Foundation of China (30970911).
WOS记录号WOS:000310118300003
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12832
专题认知与发展心理学研究室
通讯作者Zhu, LQ (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Li Jing,Lin Zhu-Mei,Zhu Li-Qi,et al. Genetic Basis and Neural Mechanism of Autism Spectrum Disorder[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(10):952-961.
APA Li Jing,Lin Zhu-Mei,Zhu Li-Qi,&Zhu, LQ .(2012).Genetic Basis and Neural Mechanism of Autism Spectrum Disorder.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(10),952-961.
MLA Li Jing,et al."Genetic Basis and Neural Mechanism of Autism Spectrum Disorder".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.10(2012):952-961.
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