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Genetic Basis and Neural Mechanism of Autism Spectrum Disorder
Li Jing1,2; Lin Zhu-Mei1,2; Zhu Li-Qi1; Zhu, LQ (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China.
2012-10-01
Source PublicationPROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN1000-3282
SubtypeArticle
Volume39Issue:10Pages:952-961
Contribution Rank1
AbstractAutism spectrum disorder (ASD) is a defective mental disease and its core impairments are social function defect, communication defect, restrictive and stereotyped behavior pattern. The paper introduces the genetic basis and neural mechanism of ASD. ASD has high genetic rate, and 5-HT and testosterone of ASD individual are both higher. Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala, cingulate gyrus, the fusiform gyrus, mirror neurons, prefrontal lobe and other brain areas, but it is inconsistent in the discrepancy direction of some areas' activation patterns. In addition, the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection. Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research.
Keywordautism spectrum disorder gene brain function brain function connectivity
Subject AreaAbnormal Psychology
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China [2010CB8339004] ; The National Natural Science Foundation of China [30970911]
Project Intro.This work was supported by grants from National Basic Research Program of China (2010CB8339004) and The National Natural Science Foundation of China (30970911).
WOS IDWOS:000310118300003
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12832
Collection认知与发展心理学研究室
Corresponding AuthorZhu, LQ (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li Jing,Lin Zhu-Mei,Zhu Li-Qi,et al. Genetic Basis and Neural Mechanism of Autism Spectrum Disorder[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(10):952-961.
APA Li Jing,Lin Zhu-Mei,Zhu Li-Qi,&Zhu, LQ .(2012).Genetic Basis and Neural Mechanism of Autism Spectrum Disorder.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(10),952-961.
MLA Li Jing,et al."Genetic Basis and Neural Mechanism of Autism Spectrum Disorder".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.10(2012):952-961.
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