| Genetic Basis and Neural Mechanism of Autism Spectrum Disorder | |
Li Jing1,2 ; Lin Zhu-Mei1,2; Zhu Li-Qi1; Zhu, LQ (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China.
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| 心理所单位排序 | 1 |
| 摘要 | Autism spectrum disorder (ASD) is a defective mental disease and its core impairments are social function defect, communication defect, restrictive and stereotyped behavior pattern. The paper introduces the genetic basis and neural mechanism of ASD. ASD has high genetic rate, and 5-HT and testosterone of ASD individual are both higher. Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala, cingulate gyrus, the fusiform gyrus, mirror neurons, prefrontal lobe and other brain areas, but it is inconsistent in the discrepancy direction of some areas' activation patterns. In addition, the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection. Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research. |
| 关键词 | autism spectrum disorder gene brain function brain function connectivity |
| 学科领域 | Abnormal Psychology |
| 2012-10-01 | |
| 语种 | 英语 |
| 发表期刊 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
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| ISSN | 1000-3282 |
| 卷号 | 39期号:10页码:952-961 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| 项目简介 | This work was supported by grants from National Basic Research Program of China (2010CB8339004) and The National Natural Science Foundation of China (30970911). |
| WOS记录号 | WOS:000310118300003 |
| 资助机构 | National Basic Research Program of China [2010CB8339004] ; The National Natural Science Foundation of China [30970911] |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/12832 |
| 专题 | 认知与发展心理学研究室 |
| 通讯作者 | Zhu, LQ (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院行为科学重点实验室 |
| 推荐引用方式 GB/T 7714 | Li Jing,Lin Zhu-Mei,Zhu Li-Qi,et al. Genetic Basis and Neural Mechanism of Autism Spectrum Disorder[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(10):952-961. |
| APA | Li Jing,Lin Zhu-Mei,Zhu Li-Qi,&Zhu, LQ .(2012).Genetic Basis and Neural Mechanism of Autism Spectrum Disorder.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(10),952-961. |
| MLA | Li Jing,et al."Genetic Basis and Neural Mechanism of Autism Spectrum Disorder".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.10(2012):952-961. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS000310118300003.p（331KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 | |
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