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Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese
Shi, Xiaohong1; Sun, Liang1; Wang, Li2; Jin, Feng3; Sun, Junfeng1; Zhu, Xiaoquan1; Tang, Lei1; Qu, Yanchun4; Yang, Ze1; Yang, Z (reprint author), Minist Hlth, Beijing Hosp, Inst Geriatr, Key Lab Geriatr, Beijing 100730, Peoples R China.
2012-06-01
Source PublicationGENETIC TESTING AND MOLECULAR BIOMARKERS
ISSN1945-0265
SubtypeArticle
Volume16Issue:6Pages:563-568
Contribution Rank3
AbstractThe aim of this study was to investigate the association between haptoglobin (Hp) gene polymorphism and occurrence of type 2 diabetes mellitus (T2DM) in a northern Chinese population. We studied the association of the Hp gene polymorphism with T2DM in 584 unrelated T2DM patients and 690 control subjects with normal glucose tolerance among northern Chinese. The patients were diagnosed in accordance with the guidelines of the American Diabetes Association. The clinical characteristics of the study population were recorded, and the Hp genotype was determined. The frequencies of the genotypes in the group of T2DM patients and the controls were as follows: Hp2-2, 51.7% and 44.1%; Hp2-1, 39.7% and 45.1%; and Hp1-1, 8.6% and 10.9%, respectively. There was significant difference for the genotypic and allelic distribution between the two groups (p = 0.021 and p = 0.007, respectively). Even after readjusting for the confounding effects of age, gender, and body mass index, a significant effect of genotypes on T2DM was still found in the recessive model for the Hp2 allele tested (p = 0.002). Those who had the Hp2-2 genotype had a significantly higher risk for T2DM than those with other genotypes (odds ratio = 1.441, 95% confidence interval = 1.143-1.817). The results showed that the Hp2-2 genotype is associated with increased risk of T2DM in the northern Chinese Han population.
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationMajor State Basic Research Development Program of China (973 Program) [2006CB503901] ; National Natural Science Foundation of China [81061120527, 30801208]
Project Intro.This research was supported by the grants from the Major State Basic Research Development Program of China (973 Program) (No. 2006CB503901) and the National Natural Science Foundation of China (No. 81061120527; No. 30801208).
WOS IDWOS:000305633000019
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Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12836
Collection中国科学院心理健康重点实验室
Corresponding AuthorYang, Z (reprint author), Minist Hlth, Beijing Hosp, Inst Geriatr, Key Lab Geriatr, Beijing 100730, Peoples R China.
Affiliation1.Minist Hlth, Beijing Hosp, Inst Geriatr, Key Lab Geriatr, Beijing 100730, Peoples R China
2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Tianjin Med Univ, Hosp 2, Tianjin Inst Urol, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Shi, Xiaohong,Sun, Liang,Wang, Li,et al. Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese[J]. GENETIC TESTING AND MOLECULAR BIOMARKERS,2012,16(6):563-568.
APA Shi, Xiaohong.,Sun, Liang.,Wang, Li.,Jin, Feng.,Sun, Junfeng.,...&Yang, Z .(2012).Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese.GENETIC TESTING AND MOLECULAR BIOMARKERS,16(6),563-568.
MLA Shi, Xiaohong,et al."Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese".GENETIC TESTING AND MOLECULAR BIOMARKERS 16.6(2012):563-568.
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