PSYCH OpenIR  > 脑与认知科学国家重点实验室
Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia
Compton, Michael T.1; Chan, Raymond C. K.2; Walker, Elaine F.3; Buckley, Peter F.4; Compton, MT (reprint author), Emory Univ, Sch Med, Dept Psychiat & Behav Sci, 49 Jesse Hill Jr Dr SE,Room 333, Atlanta, GA 30303 USA.
2011-05-01
发表期刊INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
ISSN0736-5748
文章类型Article
卷号29期号:3页码:245-250
产权排序2
摘要Minor physical anomalies (MPAs) are subtle signs of developmental deviation that are observed at anelevated frequency among patients with schizophrenia. These minor morphological abnormalities of the craniofacial region and limbs arise during fetal development and represent a set of risk markers for schizophrenia. Although MPAs are not specific to schizophrenia, established findings about MPAs vis-a-vis schizophrenia include the replicated findings that MPAs are more prevalent among individuals with schizophrenia than healthy controls, MPAs are more prevalent among individuals with schizophrenia than unaffected relatives, and MPAs are not consistently associated with symptom domains or other risk markers, such as neurological soft signs. Unresolved questions include whether or not MPAs are more prevalent among unaffected relatives than healthy controls, and which specific MPAs are most associated with schizophrenia. This overview presents three promising avenues of further research on MPAs, including: (1) studies relying on traditional summary scores that combine multiple MPAs, which may have a role in prospective risk stratification in conjunction with other risk markers and endophenotypes; (2) research on specific, quantitatively assessed MPAs (especially in specific craniofacial structures) that may inform neurodevelopmental understandings of schizophrenia; and (3) genetic studies aimed at identifying the heritable and nonheritable determinants of specific MPAs, which may increase the field's understanding of the origins of MPAs and the nature of their association with schizophrenia. (C) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
关键词Minor physical anomalies Psychosis Schizophrenia
学科领域Abnormal Psychology,Developmental Psychology
收录类别SCI
语种英语
WOS记录号WOS:000290135200007
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12856
专题脑与认知科学国家重点实验室
通讯作者Compton, MT (reprint author), Emory Univ, Sch Med, Dept Psychiat & Behav Sci, 49 Jesse Hill Jr Dr SE,Room 333, Atlanta, GA 30303 USA.
作者单位1.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30303 USA
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Emory Univ, Grad Sch Arts & Sci, Dept Psychol, Atlanta, GA 30303 USA
4.Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA
推荐引用方式
GB/T 7714
Compton, Michael T.,Chan, Raymond C. K.,Walker, Elaine F.,et al. Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2011,29(3):245-250.
APA Compton, Michael T.,Chan, Raymond C. K.,Walker, Elaine F.,Buckley, Peter F.,&Compton, MT .(2011).Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,29(3),245-250.
MLA Compton, Michael T.,et al."Minor physical anomalies: potentially informative vestiges of fetal developmental disruptions in schizophrenia".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 29.3(2011):245-250.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000290135200007.p(164KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Compton, Michael T.]的文章
[Chan, Raymond C. K.]的文章
[Walker, Elaine F.]的文章
百度学术
百度学术中相似的文章
[Compton, Michael T.]的文章
[Chan, Raymond C. K.]的文章
[Walker, Elaine F.]的文章
必应学术
必应学术中相似的文章
[Compton, Michael T.]的文章
[Chan, Raymond C. K.]的文章
[Walker, Elaine F.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000290135200007.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。