Moxibustion Attenuates Inflammatory Response to Chronic Exhaustive Exercise in Rats

	Moxibustion Attenuates Inflammatory Response to Chronic Exhaustive Exercise in Rats
	Lu, J.2; Zhang, H. -L.2; Yin, Z. -Z.2; Tu, Y.2; Li, Z. -G.2; Zhao, B. -X.2; Guo, J. -Y.1; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
心理所单位排序	2
摘要	Exercise is recognized as an activator to elicit an inflammatory response whilst moxibustion in traditional Chinese medicine has been previously found to modulate immune functioning. However, whether moxibustion can alleviate the inflammatory cytokines response to chronic exhaustive exercise remains unknown. In the present study, rats were randomly assigned to a sedentary control group (Sed), a sedentary moxibustion group (Sed + Moxa), and 2 trained groups- one submitted to a 3-week exhaustive swimming (Trained), and the other a trained moxibustion group (Trained + Moxa). We found that chronic exhaustive exercise significantly increased the serum levels of pro-inflammatory cytokines (IL-1 beta, TNF-alpha, IFN-gamma) and the IFN-gamma/IL-4 ratio, and decreased the anti-inflammatory cytokines (IL-4, IL-10). Moxibustion treatment markedly reduced the serum levels of IL-1 beta, IFN-gamma and the IFN-gamma/IL-4 ratio, while elevated the IL-4 and IL-10 productions in trained rats. However, TNF-alpha level was not significantly affected. Our results suggested that an excessive inflammatory response and a potential inflammatory damage may be involved during chronic exhaustive exercise. Moxibustion could attenuate the inflammatory impairment and have an anti-inflammatory effect. The beneficial effects of moxibustion might be mediated by reducing the pro-inflammatory cytokines, increasing the anti-inflammatory cytokines, and modulating the balance between pro- and anti-inflammatory cytokines.
关键词	exhaustive exercise cytokines inflammation moxibustion T helper
学科领域	Sports Psychology
	2012-07-01
语种	英语
发表期刊	INTERNATIONAL JOURNAL OF SPORTS MEDICINE
ISSN	0172-4622
卷号	33 期号:7 页码:580-585
期刊论文类型	Article
收录类别	SCI
项目简介	We thank Dr. Michele Audrey Ball for her advice on the manuscript. This study was supported in part by the grants from Beijing University of Chinese Medicine (No. 2008X-094) and National Basic Research Program of China (973 program, No. 2009CB522906), NNSF grant (30800301, 31170992, 81102638), the Key New Drugs Innovation project from Ministry of Science and Technology (2010ZX09102-201-018), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8) and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号	WOS:000306105600014
资助机构	Beijing University of Chinese Medicine [2008X-094] ; National Basic Research Program of China (973 program) [2009CB522906] ; NNSF [30800301, 31170992, 81102638] ; Ministry of Science and Technology [2010ZX09102-201-018] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/12861
专题	中国科学院心理健康重点实验室
通讯作者	Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Beijing Univ Chinese Med, Coll Acupuncture Moxibust & Tui Na, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Lu, J.,Zhang, H. -L.,Yin, Z. -Z.,et al. Moxibustion Attenuates Inflammatory Response to Chronic Exhaustive Exercise in Rats[J]. INTERNATIONAL JOURNAL OF SPORTS MEDICINE,2012,33(7):580-585.
APA	Lu, J..,Zhang, H. -L..,Yin, Z. -Z..,Tu, Y..,Li, Z. -G..,...&Guo, JY .(2012).Moxibustion Attenuates Inflammatory Response to Chronic Exhaustive Exercise in Rats.INTERNATIONAL JOURNAL OF SPORTS MEDICINE,33(7),580-585.
MLA	Lu, J.,et al."Moxibustion Attenuates Inflammatory Response to Chronic Exhaustive Exercise in Rats".INTERNATIONAL JOURNAL OF SPORTS MEDICINE 33.7(2012):580-585.

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