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Multilocus association mapping using generalized ridge logistic regression
Liu, Zhe2; Shen, Yuanyuan3; Ott, Jurg1; Ott, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.
2011-09-29
发表期刊BMC BIOINFORMATICS
ISSN1471-2105
文章类型Article
卷号12
产权排序3
摘要Background: In genome-wide association studies, it is widely accepted that multilocus methods are more powerful than testing single-nucleotide polymorphisms (SNPs) one at a time. Among statistical approaches considering many predictors simultaneously, scan statistics are an effective tool for detecting susceptibility genomic regions and mapping disease genes. In this study, inspired by the idea of scan statistics, we propose a novel sliding window-based method for identifying a parsimonious subset of contiguous SNPs that best predict disease status.
学科领域Physiological Psychology/biological Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者NSFC from the Chinese government [30730057, 30700442]
项目简介This work has been supported by NSFC grants from the Chinese government (project numbers 30730057 and 30700442) to JO.
WOS记录号WOS:000295848700001
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12862
专题中国科学院心理健康重点实验室
通讯作者Ott, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Univ Chicago, Dept Stat, Chicago, IL 60637 USA
3.Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
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GB/T 7714
Liu, Zhe,Shen, Yuanyuan,Ott, Jurg,et al. Multilocus association mapping using generalized ridge logistic regression[J]. BMC BIOINFORMATICS,2011,12.
APA Liu, Zhe,Shen, Yuanyuan,Ott, Jurg,&Ott, J .(2011).Multilocus association mapping using generalized ridge logistic regression.BMC BIOINFORMATICS,12.
MLA Liu, Zhe,et al."Multilocus association mapping using generalized ridge logistic regression".BMC BIOINFORMATICS 12(2011).
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