PSYCH OpenIR  > 中国科学院心理健康重点实验室
Multilocus association mapping using generalized ridge logistic regression
Liu, Zhe2; Shen, Yuanyuan3; Ott, Jurg1; Ott, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.
2011-09-29
Source PublicationBMC BIOINFORMATICS
ISSN1471-2105
SubtypeArticle
Volume12
Contribution Rank3
AbstractBackground: In genome-wide association studies, it is widely accepted that multilocus methods are more powerful than testing single-nucleotide polymorphisms (SNPs) one at a time. Among statistical approaches considering many predictors simultaneously, scan statistics are an effective tool for detecting susceptibility genomic regions and mapping disease genes. In this study, inspired by the idea of scan statistics, we propose a novel sliding window-based method for identifying a parsimonious subset of contiguous SNPs that best predict disease status.
Subject AreaPhysiological Psychology/biological Psychology
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationNSFC from the Chinese government [30730057, 30700442]
Project Intro.This work has been supported by NSFC grants from the Chinese government (project numbers 30730057 and 30700442) to JO.
WOS IDWOS:000295848700001
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12862
Collection中国科学院心理健康重点实验室
Corresponding AuthorOtt, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Univ Chicago, Dept Stat, Chicago, IL 60637 USA
3.Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
Recommended Citation
GB/T 7714
Liu, Zhe,Shen, Yuanyuan,Ott, Jurg,et al. Multilocus association mapping using generalized ridge logistic regression[J]. BMC BIOINFORMATICS,2011,12.
APA Liu, Zhe,Shen, Yuanyuan,Ott, Jurg,&Ott, J .(2011).Multilocus association mapping using generalized ridge logistic regression.BMC BIOINFORMATICS,12.
MLA Liu, Zhe,et al."Multilocus association mapping using generalized ridge logistic regression".BMC BIOINFORMATICS 12(2011).
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