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Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin
Ruan, Yeping1; Yao, Li1; Zhang, Bingbing1; Zhang, Shuijuan1; Guo, Jianyou2; Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
2012
Source PublicationDRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN0363-9045
SubtypeArticle
Volume38Issue:1Pages:123-128
Contribution Rank2
AbstractBackground: Neurotoxin-II (NT-II), an analgesic peptide which was separated from the venom of Naja naja atra, is endowed an exceptional specificity of action that block transmission of the nerve impulse by binding to the acetylcholine receptor in the membrane. However, it has limited permeability across the blood-brain barrier (BBB) after intravenously (i.v.) injection.
KeywordPolysorbate-80 nasal delivery blood-brain barrier central nervous system drug loading
Subject AreaMedical Psychology
Indexed BySCI
Language英语
Funding OrganizationNature Sciences Foundation of Zhejiang [Y2101127]
Project Intro.This project was supported by Nature Sciences Foundation of Zhejiang (Y2101127). The authors declare that they have no competing interests.
WOS IDWOS:000297470800014
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12866
Collection中国科学院心理健康重点实验室
Corresponding AuthorRuan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
Affiliation1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China
2.Chinese Acad Sci Beijing, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2012,38(1):123-128.
APA Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,Guo, Jianyou,&Ruan, YP .(2012).Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,38(1),123-128.
MLA Ruan, Yeping,et al."Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 38.1(2012):123-128.
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