Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin

	Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin
	Ruan, Yeping 1; Yao, Li 1; Zhang, Bingbing 1; Zhang, Shuijuan 1; Guo, Jianyou 2; Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
心理所单位排序	2
摘要	Background: Neurotoxin-II (NT-II), an analgesic peptide which was separated from the venom of Naja naja atra, is endowed an exceptional specificity of action that block transmission of the nerve impulse by binding to the acetylcholine receptor in the membrane. However, it has limited permeability across the blood-brain barrier (BBB) after intravenously (i.v.) injection.
关键词	Polysorbate-80 nasal delivery blood-brain barrier central nervous system drug loading
学科领域	Medical Psychology
	2012
语种	英语
发表期刊	DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN	0363-9045
卷号	38 期号:1 页码:123-128
期刊论文类型	Article
收录类别	SCI
项目简介	This project was supported by Nature Sciences Foundation of Zhejiang (Y2101127). The authors declare that they have no competing interests.
WOS记录号	WOS:000297470800014
资助机构	Nature Sciences Foundation of Zhejiang [Y2101127]
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/12866
专题	中国科学院心理健康重点实验室
通讯作者	Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
作者单位	1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China 2.Chinese Acad Sci Beijing, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2012,38(1):123-128.
APA	Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,Guo, Jianyou,&Ruan, YP .(2012).Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,38(1),123-128.
MLA	Ruan, Yeping,et al."Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 38.1(2012):123-128.

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