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Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin
Ruan, Yeping1; Yao, Li1; Zhang, Bingbing1; Zhang, Shuijuan1; Guo, Jianyou2; Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
2012
发表期刊DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN0363-9045
文章类型Article
卷号38期号:1页码:123-128
产权排序2
摘要Background: Neurotoxin-II (NT-II), an analgesic peptide which was separated from the venom of Naja naja atra, is endowed an exceptional specificity of action that block transmission of the nerve impulse by binding to the acetylcholine receptor in the membrane. However, it has limited permeability across the blood-brain barrier (BBB) after intravenously (i.v.) injection.
关键词Polysorbate-80 nasal delivery blood-brain barrier central nervous system drug loading
学科领域Medical Psychology
收录类别SCI
语种英语
项目资助者Nature Sciences Foundation of Zhejiang [Y2101127]
项目简介This project was supported by Nature Sciences Foundation of Zhejiang (Y2101127). The authors declare that they have no competing interests.
WOS记录号WOS:000297470800014
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12866
专题中国科学院心理健康重点实验室
通讯作者Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
作者单位1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China
2.Chinese Acad Sci Beijing, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2012,38(1):123-128.
APA Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,Guo, Jianyou,&Ruan, YP .(2012).Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,38(1),123-128.
MLA Ruan, Yeping,et al."Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 38.1(2012):123-128.
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