Network Centrality in the Human Functional Connectome

	Network Centrality in the Human Functional Connectome
	Zuo, Xi-Nian1,2 ; Ehmke, Ross 3; Mennes, Maarten 2; Imperati, Davide 2; Castellanos, F. Xavier 2,4; Sporns, Olaf 3; Milham, Michael P.4,5; Zuo, XN (reprint author), Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci, 4A Datun Rd, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	The network architecture of functional connectivity within the human brain connectome is poorly understood at the voxel level. Here, using resting state functional magnetic resonance imaging data from 1003 healthy adults, we investigate a broad array of network centrality measures to provide novel insights into connectivity within the whole-brain functional network (i.e., the functional connectome). We first assemble and visualize the voxel-wise (4 mm) functional connectome as a functional network. We then demonstrate that each centrality measure captures different aspects of connectivity, highlighting the importance of considering both global and local connectivity properties of the functional connectome. Beyond "detecting functional hubs," we treat centrality as measures of functional connectivity within the brain connectome and demonstrate their reliability and phenotypic correlates (i.e., age and sex). Specifically, our analyses reveal age-related decreases in degree centrality, but not eigenvector centrality, within precuneus and posterior cingulate regions. This implies that while local or (direct) connectivity decreases with age, connections with hub-like regions within the brain remain stable with age at a global level. In sum, these findings demonstrate the nonredundancy of various centrality measures and raise questions regarding their underlying physiological mechanisms that may be relevant to the study of neurodegenerative and psychiatric disorders.
关键词	functional connectome network centrality resting-state fMRI test-retest reliability whole-brain connectivity
学科领域	Cognitive Neuroscience,Medical Psychology
	2012-08-01
语种	英语
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
卷号	22 期号:8 页码:1862-1875
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	Dr X.-N.Z. acknowledges support from Startup Foundation for Distinguished Research Professor of Institute for Psychology (Y0CX492S03), the Natural Science Foundation of China (81171409), and Dr O.S. acknowledges support from the J.S. McDonnell Foundation.
WOS记录号	WOS:000307486100013
资助机构	Startup Foundation for Distinguished Research Professor of Institute for Psychology [Y0CX492S03] ; Natural Science Foundation of China [81171409] ; J.S. McDonnell Foundation
引用统计	被引频次：817[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/12868
专题	中国科学院行为科学重点实验室
通讯作者	Zuo, XN (reprint author), Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.NYU, Langone Med Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10016 USA 3.Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA 4.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA 5.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Zuo, Xi-Nian,Ehmke, Ross,Mennes, Maarten,et al. Network Centrality in the Human Functional Connectome[J]. CEREBRAL CORTEX,2012,22(8):1862-1875.
APA	Zuo, Xi-Nian.,Ehmke, Ross.,Mennes, Maarten.,Imperati, Davide.,Castellanos, F. Xavier.,...&Zuo, XN .(2012).Network Centrality in the Human Functional Connectome.CEREBRAL CORTEX,22(8),1862-1875.
MLA	Zuo, Xi-Nian,et al."Network Centrality in the Human Functional Connectome".CEREBRAL CORTEX 22.8(2012):1862-1875.

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