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Network Centrality in the Human Functional Connectome
Zuo, Xi-Nian1,2; Ehmke, Ross3; Mennes, Maarten2; Imperati, Davide2; Castellanos, F. Xavier2,4; Sporns, Olaf3; Milham, Michael P.4,5; Zuo, XN (reprint author), Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci, 4A Datun Rd, Beijing 100101, Peoples R China.
2012-08-01
Source PublicationCEREBRAL CORTEX
ISSN1047-3211
SubtypeArticle
Volume22Issue:8Pages:1862-1875
Contribution Rank1
AbstractThe network architecture of functional connectivity within the human brain connectome is poorly understood at the voxel level. Here, using resting state functional magnetic resonance imaging data from 1003 healthy adults, we investigate a broad array of network centrality measures to provide novel insights into connectivity within the whole-brain functional network (i.e., the functional connectome). We first assemble and visualize the voxel-wise (4 mm) functional connectome as a functional network. We then demonstrate that each centrality measure captures different aspects of connectivity, highlighting the importance of considering both global and local connectivity properties of the functional connectome. Beyond "detecting functional hubs," we treat centrality as measures of functional connectivity within the brain connectome and demonstrate their reliability and phenotypic correlates (i.e., age and sex). Specifically, our analyses reveal age-related decreases in degree centrality, but not eigenvector centrality, within precuneus and posterior cingulate regions. This implies that while local or (direct) connectivity decreases with age, connections with hub-like regions within the brain remain stable with age at a global level. In sum, these findings demonstrate the nonredundancy of various centrality measures and raise questions regarding their underlying physiological mechanisms that may be relevant to the study of neurodegenerative and psychiatric disorders.
Keywordfunctional connectome network centrality resting-state fMRI test-retest reliability whole-brain connectivity
Subject AreaCognitive Neuroscience,Medical Psychology
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Indexed BySCI
Language英语
Funding OrganizationStartup Foundation for Distinguished Research Professor of Institute for Psychology [Y0CX492S03] ; Natural Science Foundation of China [81171409] ; J.S. McDonnell Foundation
Project Intro.Dr X.-N.Z. acknowledges support from Startup Foundation for Distinguished Research Professor of Institute for Psychology (Y0CX492S03), the Natural Science Foundation of China (81171409), and Dr O.S. acknowledges support from the J.S. McDonnell Foundation.
WOS IDWOS:000307486100013
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12868
Collection中国科学院行为科学重点实验室
Corresponding AuthorZuo, XN (reprint author), Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci, 4A Datun Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.NYU, Langone Med Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10016 USA
3.Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
4.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
5.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA
Recommended Citation
GB/T 7714
Zuo, Xi-Nian,Ehmke, Ross,Mennes, Maarten,et al. Network Centrality in the Human Functional Connectome[J]. CEREBRAL CORTEX,2012,22(8):1862-1875.
APA Zuo, Xi-Nian.,Ehmke, Ross.,Mennes, Maarten.,Imperati, Davide.,Castellanos, F. Xavier.,...&Zuo, XN .(2012).Network Centrality in the Human Functional Connectome.CEREBRAL CORTEX,22(8),1862-1875.
MLA Zuo, Xi-Nian,et al."Network Centrality in the Human Functional Connectome".CEREBRAL CORTEX 22.8(2012):1862-1875.
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