Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality

	Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality
	Peng, Zi-wen 1,2; Xu, Ting1 ; Miao, Guo-dong 3; He, Qing-huan 3; Zhao, Qing1 ; Dazzan, Paola 4; Chan, Raymond C. K.1 ; Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, 4A Datun Rd, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Patients with obsessive-compulsive disorder (OCD) have increased rates of neurological soft signs (NSS) when compared to healthy controls. However, previous findings have been confounded by the presence of co-morbidity with disorders themselves associated with increased NSS, such as schizophrenia. Moreover, it remains unclear whether NSS in OCD reflect a vulnerability to this disorder. This study aimed to examine: 1) the severity of NSS in patients with OCD alone, in patients with OCD and co-morbid psychosis (schizophrenia or bipolar disorders), and in healthy controls; and b) whether unaffected first-degree relatives of patients with OCD also demonstrate a higher prevalence rate of NSS than healthy controls. NSS were assessed with the Cambridge Neurological Inventory (CNI) in 100 patients with OCD, 38 patients with OCD and psychosis (22 with bipolar disorders and 16 with schizophrenia), and 101 healthy controls. Forty-seven unaffected first-degree relatives of patients with OCD only were also administered the CNI. Patients with OCD showed significantly higher scores in motor coordination and total NSS than controls, and patients with OCD co-morbid with psychosis also showed significantly higher scores in motor coordination and total NSS than controls. Although there were no differences in NSS between patients with OCD only and OCD and psychosis as a whole, patients with OCD co-morbid with schizophrenia showed significantly higher scores in motor coordination than patients with OCD, patients with OCD and bipolar disorder, and healthy controls. Unaffected first-degree relatives only showed a higher prevalence rate than healthy controls in specific motor coordination signs, such as Opposition and Extinction. These findings suggest that patients with OCD exhibit more NSS than healthy controls, and that motor coordination signs may be even more extensive when OCD is co-morbid with psychosis. Some of these abnormalities may be indicative of a vulnerability to these disorders, as indicated by their presence in un-affected first-degree relatives. (c) 2012 Elsevier Inc. All rights reserved.
关键词	Co-morbidity Neurological soft signs Obsessive-compulsive disorder Unaffected siblings
学科领域	Abnormal Psychology
	2012-10-01
语种	英语
发表期刊	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN	0278-5846
卷号	39 期号:1 页码:200-205
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This study was supported partially by a grant from the National Science Fund China Young Investigator Award (81088001), the National Key Technologies R&D Program (2012BAI36B01), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of Psychology. P Dazzan's research is supported by NARSAD and the BIAL Foundation.
WOS记录号	WOS:000308630200030
资助机构	National Science Fund China Young Investigator Award [81088001] ; National Key Technologies RD Program [2012BAI36B01] ; Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology ; NARSAD ; BIAL Foundation
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/12874
专题	脑与认知科学国家重点实验室
通讯作者	Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.S China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou 510631, Guangdong, Peoples R China 3.Guangzhou Psychiat Hosp, Guangzhou 510370, Guangdong, Peoples R China 4.Kings Coll London, Inst Psychiat, London WC2R 2LS, England
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Peng, Zi-wen,Xu, Ting,Miao, Guo-dong,et al. Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2012,39(1):200-205.
APA	Peng, Zi-wen.,Xu, Ting.,Miao, Guo-dong.,He, Qing-huan.,Zhao, Qing.,...&Chan, RCK .(2012).Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,39(1),200-205.
MLA	Peng, Zi-wen,et al."Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 39.1(2012):200-205.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000308630200030.（195KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	请求全文