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Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality
Peng, Zi-wen1,2; Xu, Ting1; Miao, Guo-dong3; He, Qing-huan3; Zhao, Qing1; Dazzan, Paola4; Chan, Raymond C. K.1; Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, 4A Datun Rd, Beijing 100101, Peoples R China.
2012-10-01
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
SubtypeArticle
Volume39Issue:1Pages:200-205
Contribution Rank1
AbstractPatients with obsessive-compulsive disorder (OCD) have increased rates of neurological soft signs (NSS) when compared to healthy controls. However, previous findings have been confounded by the presence of co-morbidity with disorders themselves associated with increased NSS, such as schizophrenia. Moreover, it remains unclear whether NSS in OCD reflect a vulnerability to this disorder. This study aimed to examine: 1) the severity of NSS in patients with OCD alone, in patients with OCD and co-morbid psychosis (schizophrenia or bipolar disorders), and in healthy controls; and b) whether unaffected first-degree relatives of patients with OCD also demonstrate a higher prevalence rate of NSS than healthy controls. NSS were assessed with the Cambridge Neurological Inventory (CNI) in 100 patients with OCD, 38 patients with OCD and psychosis (22 with bipolar disorders and 16 with schizophrenia), and 101 healthy controls. Forty-seven unaffected first-degree relatives of patients with OCD only were also administered the CNI. Patients with OCD showed significantly higher scores in motor coordination and total NSS than controls, and patients with OCD co-morbid with psychosis also showed significantly higher scores in motor coordination and total NSS than controls. Although there were no differences in NSS between patients with OCD only and OCD and psychosis as a whole, patients with OCD co-morbid with schizophrenia showed significantly higher scores in motor coordination than patients with OCD, patients with OCD and bipolar disorder, and healthy controls. Unaffected first-degree relatives only showed a higher prevalence rate than healthy controls in specific motor coordination signs, such as Opposition and Extinction. These findings suggest that patients with OCD exhibit more NSS than healthy controls, and that motor coordination signs may be even more extensive when OCD is co-morbid with psychosis. Some of these abnormalities may be indicative of a vulnerability to these disorders, as indicated by their presence in un-affected first-degree relatives. (c) 2012 Elsevier Inc. All rights reserved.
KeywordCo-morbidity Neurological soft signs Obsessive-compulsive disorder Unaffected siblings
Subject AreaAbnormal Psychology
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Indexed BySCI
Language英语
Funding OrganizationNational Science Fund China Young Investigator Award [81088001] ; National Key Technologies RD Program [2012BAI36B01] ; Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology ; NARSAD ; BIAL Foundation
Project Intro.This study was supported partially by a grant from the National Science Fund China Young Investigator Award (81088001), the National Key Technologies R&D Program (2012BAI36B01), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of Psychology. P Dazzan's research is supported by NARSAD and the BIAL Foundation.
WOS IDWOS:000308630200030
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Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12874
Collection脑与认知科学国家重点实验室
Corresponding AuthorChan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, 4A Datun Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.S China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou 510631, Guangdong, Peoples R China
3.Guangzhou Psychiat Hosp, Guangzhou 510370, Guangdong, Peoples R China
4.Kings Coll London, Inst Psychiat, London WC2R 2LS, England
Recommended Citation
GB/T 7714
Peng, Zi-wen,Xu, Ting,Miao, Guo-dong,et al. Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2012,39(1):200-205.
APA Peng, Zi-wen.,Xu, Ting.,Miao, Guo-dong.,He, Qing-huan.,Zhao, Qing.,...&Chan, RCK .(2012).Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,39(1),200-205.
MLA Peng, Zi-wen,et al."Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 39.1(2012):200-205.
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