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Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD
Li Juan; Yu Jing; Niu Ya-Nan; Li, J (reprint author), Chinese Acad Sci, Ctr Ageing Psychol, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012-08-01
发表期刊PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN1000-3282
文章类型Article
卷号39期号:8页码:804-810
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摘要Mild cognitive impairment (MCI) is an intermediate clinical state between normal aging and dementia, and MCI patients are the risk population for the development of Alzheimer's disease (AD). This article firstly introduced the international diagnosis criteria of MCI and its variations and modifications, and based on the previous findings, we proposed an ideal diagnosis model for MCI detection in which outmeasures included both patient's self-report, clinician's judgment and objective behavioral and neuropsychological tests as well as various biomarkers through advanced imaging techniques, cerebrospinal fluid analysis, or even urine endogenous formaldehyde analysis, both cross-sectional comparisons of an individual with the norms and longitudinal changes derived from multi-time point measurements were also involved. We reviewed the recent studies on the neuropsychological impairment characteristics of MCI and the corresponding measurement tools from both cognitive and neuropsychiatric aspects such as MMSE, MoCA, NPI and SCID, and various cognitive intervention methods for MCI were also reviewed. Future research is needed to extend the findings from experimental small samples into community-based large population, as well as from the cross-sectional studies into longitudinal studies, and to adopt multi-detection markers and multi-intervention methods to achieve the optimal effects of early detection and intervention of MCI.
关键词Alzheimer's disease mild cognitive impairment early detection neuropsychology intervention
学科领域Abnormal Psychology
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [30770725, 31070916] ; National Science & Technology Pillar Program of China [2009BAI77B03] ; Knowledge Innovation Project of The Chinese Academy of Sciences [KSCX2-EW-J-8]
项目简介This work was supported by grants from The National Natural Science Foundation of China (30770725, 31070916), National Science & Technology Pillar Program of China (2009BAI77B03) and Knowledge Innovation Project of The Chinese Academy of Sciences (KSCX2-EW-J-8).
WOS记录号WOS:000307851900019
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12876
专题中国科学院心理健康重点实验室
通讯作者Li, J (reprint author), Chinese Acad Sci, Ctr Ageing Psychol, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位Chinese Acad Sci, Ctr Ageing Psychol, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Li Juan,Yu Jing,Niu Ya-Nan,et al. Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(8):804-810.
APA Li Juan,Yu Jing,Niu Ya-Nan,&Li, J .(2012).Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(8),804-810.
MLA Li Juan,et al."Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.8(2012):804-810.
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