PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD
Li Juan; Yu Jing; Niu Ya-Nan; Li, J (reprint author), Chinese Acad Sci, Ctr Ageing Psychol, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012-08-01
Source PublicationPROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN1000-3282
SubtypeArticle
Volume39Issue:8Pages:804-810
Contribution Rank1
AbstractMild cognitive impairment (MCI) is an intermediate clinical state between normal aging and dementia, and MCI patients are the risk population for the development of Alzheimer's disease (AD). This article firstly introduced the international diagnosis criteria of MCI and its variations and modifications, and based on the previous findings, we proposed an ideal diagnosis model for MCI detection in which outmeasures included both patient's self-report, clinician's judgment and objective behavioral and neuropsychological tests as well as various biomarkers through advanced imaging techniques, cerebrospinal fluid analysis, or even urine endogenous formaldehyde analysis, both cross-sectional comparisons of an individual with the norms and longitudinal changes derived from multi-time point measurements were also involved. We reviewed the recent studies on the neuropsychological impairment characteristics of MCI and the corresponding measurement tools from both cognitive and neuropsychiatric aspects such as MMSE, MoCA, NPI and SCID, and various cognitive intervention methods for MCI were also reviewed. Future research is needed to extend the findings from experimental small samples into community-based large population, as well as from the cross-sectional studies into longitudinal studies, and to adopt multi-detection markers and multi-intervention methods to achieve the optimal effects of early detection and intervention of MCI.
KeywordAlzheimer's disease mild cognitive impairment early detection neuropsychology intervention
Subject AreaAbnormal Psychology
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [30770725, 31070916] ; National Science & Technology Pillar Program of China [2009BAI77B03] ; Knowledge Innovation Project of The Chinese Academy of Sciences [KSCX2-EW-J-8]
Project Intro.This work was supported by grants from The National Natural Science Foundation of China (30770725, 31070916), National Science & Technology Pillar Program of China (2009BAI77B03) and Knowledge Innovation Project of The Chinese Academy of Sciences (KSCX2-EW-J-8).
WOS IDWOS:000307851900019
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12876
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, J (reprint author), Chinese Acad Sci, Ctr Ageing Psychol, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
AffiliationChinese Acad Sci, Ctr Ageing Psychol, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Li Juan,Yu Jing,Niu Ya-Nan,et al. Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(8):804-810.
APA Li Juan,Yu Jing,Niu Ya-Nan,&Li, J .(2012).Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(8),804-810.
MLA Li Juan,et al."Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.8(2012):804-810.
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