PSYCH OpenIR  > 中国科学院心理健康重点实验室
Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal
Li, Yonghui2; Wang, Huiying3; Qi, Keke3; Chen, Xiaoyu1; Li, Sa1; Sui, Nan3; Kirouac, Gilbert J.1,4; Kirouac, GJ (reprint author), Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada.
2011-01-10
发表期刊PHYSIOLOGY & BEHAVIOR
ISSN0031-9384
文章类型Article
卷号102期号:1页码:42-50
产权排序1
摘要Previous studies have implicated the bed nucleus of the stria terminalis, central nucleus of the amygdala and the shell of the nucleus accumbens (collectively called the extended amygdala) as playing an important role in mediating the aversive emotion associated with opioid withdrawal. The paraventricular nucleus of the thalamus (PVT) provides a very dense input to the extended amygdala, and the PVT is densely innervated by orexin neurons, which appear to be involved in producing some of the physical and emotional effects associated with morphine withdrawal. In the present study, we confirm that the PVT is densely innervated by orexin fibers, whereas the regions of the extended amygdala associated with the effects of morphine withdrawal are poorly innervated. Microinjections of the orexin-1 receptor (OX1R) antagonist SB334867 or the orexin-2 receptor (OX2R) antagonist TCSOX229 at doses of 5.0 or 15.0 mu g into the PVT region did not affect the acquisition of the conditioned place aversion (CPA) nor the physical effects produced by naloxone-precipitated morphine withdrawal. In contrast, microinjections of TCSOX229 (15.0 mu g) in the PVT region significantly attenuated the expression of naloxone-induced CPA while microinjections of SB334867 at the same dose had no effect. The results from these experiments indicate a role for OX2R in the PVT on the expression of CPA associated with morphine withdrawal. Orexins may mediate the aversive effects of morphine withdrawal by engaging the extended amygdala indirectly through the action of orexins on the PVT. (C) 2010 Elsevier Inc. All rights reserved.
关键词Orexin Hypocretin Morphine withdrawal Thalamus Extended amygdala Conditioned place aversion
学科领域Physiological Psychology/biological Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者Canadian Institutes of Health Research (CIHR) [MOP68909] ; National Basic Research Program ; Chinese Academy of Sciences [2009CB522002, KSCXI-YW-R-68] ; NSFC ; Institute of Psychology, CAS [31070911, 07CX081008]
项目简介The study was supported by the Canadian Institutes of Health Research (CIHR; MOP68909 to G.J.K.); the National Basic Research Program grants and the Chinese Academy of Sciences grant (2009CB522002, KSCXI-YW-R-68 to N.S.); and the NSFC grants and the Project for Young Scientists Fund, Institute of Psychology, CAS (31070911, 07CX081008 to Y.L.).
WOS记录号WOS:000286288000008
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12883
专题中国科学院心理健康重点实验室
通讯作者Kirouac, GJ (reprint author), Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada.
作者单位1.Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Behav Pharmacol Lab, Beijing 100101, Peoples R China
4.Univ Manitoba, Dept Psychiat, Fac Med, Winnipeg, MB R3T 2N2, Canada
推荐引用方式
GB/T 7714
Li, Yonghui,Wang, Huiying,Qi, Keke,et al. Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal[J]. PHYSIOLOGY & BEHAVIOR,2011,102(1):42-50.
APA Li, Yonghui.,Wang, Huiying.,Qi, Keke.,Chen, Xiaoyu.,Li, Sa.,...&Kirouac, GJ .(2011).Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal.PHYSIOLOGY & BEHAVIOR,102(1),42-50.
MLA Li, Yonghui,et al."Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal".PHYSIOLOGY & BEHAVIOR 102.1(2011):42-50.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000286288000008.p(1188KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Yonghui]的文章
[Wang, Huiying]的文章
[Qi, Keke]的文章
百度学术
百度学术中相似的文章
[Li, Yonghui]的文章
[Wang, Huiying]的文章
[Qi, Keke]的文章
必应学术
必应学术中相似的文章
[Li, Yonghui]的文章
[Wang, Huiying]的文章
[Qi, Keke]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000286288000008.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。