Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal

	Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal
	Li, Yonghui2 ; Wang, Huiying3 ; Qi, Keke3 ; Chen, Xiaoyu 1; Li, Sa 1; Sui, Nan3 ; Kirouac, Gilbert J.1,4; Kirouac, GJ (reprint author), Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada.
心理所单位排序	1
摘要	Previous studies have implicated the bed nucleus of the stria terminalis, central nucleus of the amygdala and the shell of the nucleus accumbens (collectively called the extended amygdala) as playing an important role in mediating the aversive emotion associated with opioid withdrawal. The paraventricular nucleus of the thalamus (PVT) provides a very dense input to the extended amygdala, and the PVT is densely innervated by orexin neurons, which appear to be involved in producing some of the physical and emotional effects associated with morphine withdrawal. In the present study, we confirm that the PVT is densely innervated by orexin fibers, whereas the regions of the extended amygdala associated with the effects of morphine withdrawal are poorly innervated. Microinjections of the orexin-1 receptor (OX1R) antagonist SB334867 or the orexin-2 receptor (OX2R) antagonist TCSOX229 at doses of 5.0 or 15.0 mu g into the PVT region did not affect the acquisition of the conditioned place aversion (CPA) nor the physical effects produced by naloxone-precipitated morphine withdrawal. In contrast, microinjections of TCSOX229 (15.0 mu g) in the PVT region significantly attenuated the expression of naloxone-induced CPA while microinjections of SB334867 at the same dose had no effect. The results from these experiments indicate a role for OX2R in the PVT on the expression of CPA associated with morphine withdrawal. Orexins may mediate the aversive effects of morphine withdrawal by engaging the extended amygdala indirectly through the action of orexins on the PVT. (C) 2010 Elsevier Inc. All rights reserved.
关键词	Orexin Hypocretin Morphine withdrawal Thalamus Extended amygdala Conditioned place aversion
学科领域	Physiological Psychology/biological Psychology
	2011-01-10
语种	英语
发表期刊	PHYSIOLOGY & BEHAVIOR
ISSN	0031-9384
卷号	102 期号:1 页码:42-50
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	The study was supported by the Canadian Institutes of Health Research (CIHR; MOP68909 to G.J.K.); the National Basic Research Program grants and the Chinese Academy of Sciences grant (2009CB522002, KSCXI-YW-R-68 to N.S.); and the NSFC grants and the Project for Young Scientists Fund, Institute of Psychology, CAS (31070911, 07CX081008 to Y.L.).
WOS记录号	WOS:000286288000008
资助机构	Canadian Institutes of Health Research (CIHR) [MOP68909] ; National Basic Research Program ; Chinese Academy of Sciences [2009CB522002, KSCXI-YW-R-68] ; NSFC ; Institute of Psychology, CAS [31070911, 07CX081008]
引用统计	被引频次：53[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/12883
专题	中国科学院心理健康重点实验室
通讯作者	Kirouac, GJ (reprint author), Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada.
作者单位	1.Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Behav Pharmacol Lab, Beijing 100101, Peoples R China 4.Univ Manitoba, Dept Psychiat, Fac Med, Winnipeg, MB R3T 2N2, Canada
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Yonghui,Wang, Huiying,Qi, Keke,et al. Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal[J]. PHYSIOLOGY & BEHAVIOR,2011,102(1):42-50.
APA	Li, Yonghui.,Wang, Huiying.,Qi, Keke.,Chen, Xiaoyu.,Li, Sa.,...&Kirouac, GJ .(2011).Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal.PHYSIOLOGY & BEHAVIOR,102(1),42-50.
MLA	Li, Yonghui,et al."Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal".PHYSIOLOGY & BEHAVIOR 102.1(2011):42-50.

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