PSYCH OpenIR  > 中国科学院心理健康重点实验室
Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal
Li, Yonghui2; Wang, Huiying3; Qi, Keke3; Chen, Xiaoyu1; Li, Sa1; Sui, Nan3; Kirouac, Gilbert J.1,4; Kirouac, GJ (reprint author), Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada.
2011-01-10
Source PublicationPHYSIOLOGY & BEHAVIOR
ISSN0031-9384
SubtypeArticle
Volume102Issue:1Pages:42-50
Contribution Rank1
AbstractPrevious studies have implicated the bed nucleus of the stria terminalis, central nucleus of the amygdala and the shell of the nucleus accumbens (collectively called the extended amygdala) as playing an important role in mediating the aversive emotion associated with opioid withdrawal. The paraventricular nucleus of the thalamus (PVT) provides a very dense input to the extended amygdala, and the PVT is densely innervated by orexin neurons, which appear to be involved in producing some of the physical and emotional effects associated with morphine withdrawal. In the present study, we confirm that the PVT is densely innervated by orexin fibers, whereas the regions of the extended amygdala associated with the effects of morphine withdrawal are poorly innervated. Microinjections of the orexin-1 receptor (OX1R) antagonist SB334867 or the orexin-2 receptor (OX2R) antagonist TCSOX229 at doses of 5.0 or 15.0 mu g into the PVT region did not affect the acquisition of the conditioned place aversion (CPA) nor the physical effects produced by naloxone-precipitated morphine withdrawal. In contrast, microinjections of TCSOX229 (15.0 mu g) in the PVT region significantly attenuated the expression of naloxone-induced CPA while microinjections of SB334867 at the same dose had no effect. The results from these experiments indicate a role for OX2R in the PVT on the expression of CPA associated with morphine withdrawal. Orexins may mediate the aversive effects of morphine withdrawal by engaging the extended amygdala indirectly through the action of orexins on the PVT. (C) 2010 Elsevier Inc. All rights reserved.
KeywordOrexin Hypocretin Morphine withdrawal Thalamus Extended amygdala Conditioned place aversion
Subject AreaPhysiological Psychology/biological Psychology
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationCanadian Institutes of Health Research (CIHR) [MOP68909] ; National Basic Research Program ; Chinese Academy of Sciences [2009CB522002, KSCXI-YW-R-68] ; NSFC ; Institute of Psychology, CAS [31070911, 07CX081008]
Project Intro.The study was supported by the Canadian Institutes of Health Research (CIHR; MOP68909 to G.J.K.); the National Basic Research Program grants and the Chinese Academy of Sciences grant (2009CB522002, KSCXI-YW-R-68 to N.S.); and the NSFC grants and the Project for Young Scientists Fund, Institute of Psychology, CAS (31070911, 07CX081008 to Y.L.).
WOS IDWOS:000286288000008
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12883
Collection中国科学院心理健康重点实验室
Corresponding AuthorKirouac, GJ (reprint author), Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada.
Affiliation1.Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB, Canada
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Behav Pharmacol Lab, Beijing 100101, Peoples R China
4.Univ Manitoba, Dept Psychiat, Fac Med, Winnipeg, MB R3T 2N2, Canada
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Yonghui,Wang, Huiying,Qi, Keke,et al. Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal[J]. PHYSIOLOGY & BEHAVIOR,2011,102(1):42-50.
APA Li, Yonghui.,Wang, Huiying.,Qi, Keke.,Chen, Xiaoyu.,Li, Sa.,...&Kirouac, GJ .(2011).Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal.PHYSIOLOGY & BEHAVIOR,102(1),42-50.
MLA Li, Yonghui,et al."Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal".PHYSIOLOGY & BEHAVIOR 102.1(2011):42-50.
Files in This Item:
File Name/Size DocType Version Access License
WOS000286288000008.p(1188KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Yonghui]'s Articles
[Wang, Huiying]'s Articles
[Qi, Keke]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Yonghui]'s Articles
[Wang, Huiying]'s Articles
[Qi, Keke]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Yonghui]'s Articles
[Wang, Huiying]'s Articles
[Qi, Keke]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: WOS000286288000008.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.