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Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study
Zhang KunLin1; Zhang LiuYan1,2; Zhang WeiNa1,2; Wang Jing1; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011-11-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
SubtypeArticle
Volume56Issue:32Pages:3398-3402
Contribution Rank1
AbstractSchizophrenia (SZ) is an inheritable complex mental disease. There have been several genome-wide association studies (GWASs) of SZ to identify novel genetic susceptibility factors. To further interpret SZ GWASs, pathway-based analysis (PBA), which considers the combined effect of variants and identifies pathways associated with traits, provides a feasible solution to discover the biological function and mechanism of SZ. Furthermore, to investigate the common pathways between SZ and bipolar disorder (BD) will help explore common mechanism between psychiatric phenotypes. We performed a PBA, called improved gene set enrichment analysis (i-GSEA), on 3 independent GWASs of SZ to identify pathways associated with SZ. The results were further compared to the BD-associated pathways identified by i-GSEA for 2 BD GWASs and from literature reports. Our analysis identified a highly statistically significant association between SZ and pathway 'substrate specific channel activity' in all 3 SZ GWASs (false discovery rate (FDR) < 0.05). This association has not been reported elsewhere before. This pathway was also identified by PBA for 2 independent BD GWASs. Our results suggest that pathway 'substrate specific channel activity' is statistically significantly associated with SZ, and SZ and BD share the common biological function and mechanism represented by this pathway.
Keywordschizophrenia (SZ) genome-wide association study (GWAS) pathway-based analysis (PBA) bipolar disorder (BD)
Subject AreaAbnormal Psychology
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Indexed BySCI
Language英语
Funding OrganizationChinese Academy of Sciences [KSCX2-EW-J-8] ; Institute of Psychology, Chinese Academy of Sciences [O9CX115011]
Project Intro.This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (O9CX115011).
WOS IDWOS:000296641800008
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12886
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang KunLin,Zhang LiuYan,Zhang WeiNa,et al. Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3398-3402.
APA Zhang KunLin,Zhang LiuYan,Zhang WeiNa,Wang Jing,&Wang, J .(2011).Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study.CHINESE SCIENCE BULLETIN,56(32),3398-3402.
MLA Zhang KunLin,et al."Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study".CHINESE SCIENCE BULLETIN 56.32(2011):3398-3402.
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