Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study

	Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study
	Zhang KunLin1 ; Zhang LiuYan1,2 ; Zhang WeiNa1,2 ; Wang Jing1 ; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Schizophrenia (SZ) is an inheritable complex mental disease. There have been several genome-wide association studies (GWASs) of SZ to identify novel genetic susceptibility factors. To further interpret SZ GWASs, pathway-based analysis (PBA), which considers the combined effect of variants and identifies pathways associated with traits, provides a feasible solution to discover the biological function and mechanism of SZ. Furthermore, to investigate the common pathways between SZ and bipolar disorder (BD) will help explore common mechanism between psychiatric phenotypes. We performed a PBA, called improved gene set enrichment analysis (i-GSEA), on 3 independent GWASs of SZ to identify pathways associated with SZ. The results were further compared to the BD-associated pathways identified by i-GSEA for 2 BD GWASs and from literature reports. Our analysis identified a highly statistically significant association between SZ and pathway 'substrate specific channel activity' in all 3 SZ GWASs (false discovery rate (FDR) < 0.05). This association has not been reported elsewhere before. This pathway was also identified by PBA for 2 independent BD GWASs. Our results suggest that pathway 'substrate specific channel activity' is statistically significantly associated with SZ, and SZ and BD share the common biological function and mechanism represented by this pathway.
关键词	schizophrenia (SZ) genome-wide association study (GWAS) pathway-based analysis (PBA) bipolar disorder (BD)
学科领域	Abnormal Psychology
	2011-11-01
语种	英语
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	56 期号:32 页码:3398-3402
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (O9CX115011).
WOS记录号	WOS:000296641800008
资助机构	Chinese Academy of Sciences [KSCX2-EW-J-8] ; Institute of Psychology, Chinese Academy of Sciences [O9CX115011]
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/12886
专题	中国科学院心理健康重点实验室
通讯作者	Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhang KunLin,Zhang LiuYan,Zhang WeiNa,et al. Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3398-3402.
APA	Zhang KunLin,Zhang LiuYan,Zhang WeiNa,Wang Jing,&Wang, J .(2011).Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study.CHINESE SCIENCE BULLETIN,56(32),3398-3402.
MLA	Zhang KunLin,et al."Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study".CHINESE SCIENCE BULLETIN 56.32(2011):3398-3402.

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