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Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study
Zhang KunLin1; Zhang LiuYan1,2; Zhang WeiNa1,2; Wang Jing1; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011-11-01
发表期刊CHINESE SCIENCE BULLETIN
ISSN1001-6538
文章类型Article
卷号56期号:32页码:3398-3402
产权排序1
摘要Schizophrenia (SZ) is an inheritable complex mental disease. There have been several genome-wide association studies (GWASs) of SZ to identify novel genetic susceptibility factors. To further interpret SZ GWASs, pathway-based analysis (PBA), which considers the combined effect of variants and identifies pathways associated with traits, provides a feasible solution to discover the biological function and mechanism of SZ. Furthermore, to investigate the common pathways between SZ and bipolar disorder (BD) will help explore common mechanism between psychiatric phenotypes. We performed a PBA, called improved gene set enrichment analysis (i-GSEA), on 3 independent GWASs of SZ to identify pathways associated with SZ. The results were further compared to the BD-associated pathways identified by i-GSEA for 2 BD GWASs and from literature reports. Our analysis identified a highly statistically significant association between SZ and pathway 'substrate specific channel activity' in all 3 SZ GWASs (false discovery rate (FDR) < 0.05). This association has not been reported elsewhere before. This pathway was also identified by PBA for 2 independent BD GWASs. Our results suggest that pathway 'substrate specific channel activity' is statistically significantly associated with SZ, and SZ and BD share the common biological function and mechanism represented by this pathway.
关键词schizophrenia (SZ) genome-wide association study (GWAS) pathway-based analysis (PBA) bipolar disorder (BD)
学科领域Abnormal Psychology
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收录类别SCI
语种英语
项目资助者Chinese Academy of Sciences [KSCX2-EW-J-8] ; Institute of Psychology, Chinese Academy of Sciences [O9CX115011]
项目简介This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (O9CX115011).
WOS记录号WOS:000296641800008
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12886
专题中国科学院心理健康重点实验室
通讯作者Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Zhang KunLin,Zhang LiuYan,Zhang WeiNa,et al. Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3398-3402.
APA Zhang KunLin,Zhang LiuYan,Zhang WeiNa,Wang Jing,&Wang, J .(2011).Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study.CHINESE SCIENCE BULLETIN,56(32),3398-3402.
MLA Zhang KunLin,et al."Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study".CHINESE SCIENCE BULLETIN 56.32(2011):3398-3402.
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