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Personality Is Reflected in the Brain's Intrinsic Functional Architecture
Adelstein, Jonathan S.1; Shehzad, Zarrar2; Mennes, Maarten1; DeYoung, Colin G.3; Zuo, Xi-Nian1,4; Kelly, Clare1; Margulies, Daniel S.5,6; Bloomfield, Aaron1; Gray, Jeremy R.2; Castellanos, F. Xavier1,7; Milham, Michael P.7,8; Adelstein, JS (reprint author), NYU, Langone Med Ctr, NYU Child Study Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10012 USA.
2011-11-30
Source PublicationPLOS ONE
ISSN1932-6203
SubtypeArticle
Volume6Issue:11Pages:e27633
Contribution Rank4
AbstractPersonality describes persistent human behavioral responses to broad classes of environmental stimuli. Investigating how personality traits are reflected in the brain's functional architecture is challenging, in part due to the difficulty of designing appropriate task probes. Resting-state functional connectivity (RSFC) can detect intrinsic activation patterns without relying on any specific task. Here we use RSFC to investigate the neural correlates of the five-factor personality domains. Based on seed regions placed within two cognitive and affective 'hubs' in the brain-the anterior cingulate and precuneus-each domain of personality predicted RSFC with a unique pattern of brain regions. These patterns corresponded with functional subdivisions responsible for cognitive and affective processing such as motivation, empathy and future-oriented thinking. Neuroticism and Extraversion, the two most widely studied of the five constructs, predicted connectivity between seed regions and the dorsomedial prefrontal cortex and lateral paralimbic regions, respectively. These areas are associated with emotional regulation, self-evaluation and reward, consistent with the trait qualities. Personality traits were mostly associated with functional connections that were inconsistently present across participants. This suggests that although a fundamental, core functional architecture is preserved across individuals, variable connections outside of that core encompass the inter-individual differences in personality that motivate diverse responses.
Subject AreaPersonality Psychology,Social Psychology
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Indexed BySCI
Language英语
Funding OrganizationHoward Hughes Medical Institute ; National Institute of Mental Health [R01MH083246, R01MH081218] ; National Institute on Drug Abuse [R03DA024775, R01DA016979] ; Autism Speaks ; National Science and Engineering Research Council of Canada ; Startup Foundation for Distinguished Research Professor of Institute for Psychology ; Natural Science Foundation of China [Y0CX492S03, 81171409] ; Stavros Niarchos Foundation ; Leon Levy Foundation
Project Intro.This work was supported by grants from the Howard Hughes Medical Institute (to J.S.A.), the National Institute of Mental Health (R01MH083246 and R01MH081218 to F. X. C. and M. P. M.), National Institute on Drug Abuse (R03DA024775, to C. K.; R01DA016979, to F. X. C.) and Autism Speaks, a Post-Graduate Fellowship from the National Science and Engineering Research Council of Canada (to Z.S.), the Startup Foundation for Distinguished Research Professor of Institute for Psychology and the Natural Science Foundation of China (Y0CX492S03 and 81171409 to X-N.Z.) as well as gifts to the New York University Child Study Center from the Stavros Niarchos Foundation, Leon Levy Foundation, and an endowment provided by Phyllis Green and Randolph Cowen. Funders had no role in the design of the study, data analyses or interpretation or presentation of results.
WOS IDWOS:000298168100014
Citation statistics
Cited Times:133[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12892
Collection中国科学院行为科学重点实验室
Corresponding AuthorAdelstein, JS (reprint author), NYU, Langone Med Ctr, NYU Child Study Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10012 USA.
Affiliation1.NYU, Langone Med Ctr, NYU Child Study Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10012 USA
2.Yale Univ, Dept Psychol, New Haven, CT 06520 USA
3.Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Lab Funct Connectome & Dev, Beijing 100101, Peoples R China
5.Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany
6.Univ Berlin, Mind & Brain Inst, Berlin, Germany
7.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
8.Child Mind Inst, Ctr Developing Brain, New York, NY USA
Recommended Citation
GB/T 7714
Adelstein, Jonathan S.,Shehzad, Zarrar,Mennes, Maarten,et al. Personality Is Reflected in the Brain's Intrinsic Functional Architecture[J]. PLOS ONE,2011,6(11):e27633.
APA Adelstein, Jonathan S..,Shehzad, Zarrar.,Mennes, Maarten.,DeYoung, Colin G..,Zuo, Xi-Nian.,...&Adelstein, JS .(2011).Personality Is Reflected in the Brain's Intrinsic Functional Architecture.PLOS ONE,6(11),e27633.
MLA Adelstein, Jonathan S.,et al."Personality Is Reflected in the Brain's Intrinsic Functional Architecture".PLOS ONE 6.11(2011):e27633.
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