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PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW
Cuijpers, Pim1,2; Reynolds, Charles F., III3; Donker, Tara1,2; Li, Juan4; Andersson, Gerhard5,6; Beekman, Aartjan7; Cuijpers, P (reprint author), Vrije Univ Amsterdam, Dept Clin Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
2012-10-01
Source PublicationDEPRESSION AND ANXIETY
ISSN1091-4269
SubtypeArticle
Volume29Issue:10Pages:855-864
Contribution Rank4
AbstractBackground Personalized medicine aims to identify which characteristics of an individual predict the outcome of a specific treatment, in order to get a better match between the individual and the treatment received. We conducted a systematic review and meta-analysis of randomized trials comparing two treatments directly in a group of patients with a specific characteristic. Methods We searched relevant studies from bibliographical databases and included trials comparing (1) medication with psychotherapy, (2) medication with combined treatment, and (3) psychotherapy with combined treatment, in specific target groups (a) with a predefined sociodemographic characteristic, (b) a specific type of depression, (c) a comorbid mental or somatic disorder, or (d) from a specific setting (outpatients, primary care). Results We included 52 studies with 4,734 depressed patients. In these studies, 20 characteristics of the target groups were examined. The results showed that medication is probably the best treatment for dysthymia, and combined treatments are more effective in depressed outpatients, as well as in depressed older adults. However, in order to examine the 20 characteristics in the three categories of comparisons, 254 studies would be needed for having sufficient statistical power to show an effect size of g = 0.5. Currently, only 20.1% of these studies have been conducted. Conclusions Although a considerable number of studies have compared medication, psychotherapy, and combined treatments, and some preliminary results are useful for deciding which treatment is best for which patient, the development of personalized treatment of depression has only just begun.
Keywordantidepressants clinical trials depression dysthymic disorder treatment
Subject AreaPersonality Psychology,Cognitive Neuroscience
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Indexed BySSCI
Language英语
WOS IDWOS:000309394600004
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12893
Collection中国科学院心理健康重点实验室
Corresponding AuthorCuijpers, P (reprint author), Vrije Univ Amsterdam, Dept Clin Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
Affiliation1.Vrije Univ Amsterdam, Dept Clin Psychol, NL-1081 BT Amsterdam, Netherlands
2.Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands
3.Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
5.Linkoping Univ, Swedish Inst Disabil Res, Dept Behav Sci & Learning, S-58183 Linkoping, Sweden
6.Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, Stockholm, Sweden
7.Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Psychiat, Amsterdam, Netherlands
Recommended Citation
GB/T 7714
Cuijpers, Pim,Reynolds, Charles F., III,Donker, Tara,et al. PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW[J]. DEPRESSION AND ANXIETY,2012,29(10):855-864.
APA Cuijpers, Pim.,Reynolds, Charles F., III.,Donker, Tara.,Li, Juan.,Andersson, Gerhard.,...&Cuijpers, P .(2012).PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW.DEPRESSION AND ANXIETY,29(10),855-864.
MLA Cuijpers, Pim,et al."PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW".DEPRESSION AND ANXIETY 29.10(2012):855-864.
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