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PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW
Cuijpers, Pim1,2; Reynolds, Charles F., III3; Donker, Tara1,2; Li, Juan4; Andersson, Gerhard5,6; Beekman, Aartjan7; Cuijpers, P (reprint author), Vrije Univ Amsterdam, Dept Clin Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
2012-10-01
发表期刊DEPRESSION AND ANXIETY
ISSN1091-4269
文章类型Article
卷号29期号:10页码:855-864
产权排序4
摘要Background Personalized medicine aims to identify which characteristics of an individual predict the outcome of a specific treatment, in order to get a better match between the individual and the treatment received. We conducted a systematic review and meta-analysis of randomized trials comparing two treatments directly in a group of patients with a specific characteristic. Methods We searched relevant studies from bibliographical databases and included trials comparing (1) medication with psychotherapy, (2) medication with combined treatment, and (3) psychotherapy with combined treatment, in specific target groups (a) with a predefined sociodemographic characteristic, (b) a specific type of depression, (c) a comorbid mental or somatic disorder, or (d) from a specific setting (outpatients, primary care). Results We included 52 studies with 4,734 depressed patients. In these studies, 20 characteristics of the target groups were examined. The results showed that medication is probably the best treatment for dysthymia, and combined treatments are more effective in depressed outpatients, as well as in depressed older adults. However, in order to examine the 20 characteristics in the three categories of comparisons, 254 studies would be needed for having sufficient statistical power to show an effect size of g = 0.5. Currently, only 20.1% of these studies have been conducted. Conclusions Although a considerable number of studies have compared medication, psychotherapy, and combined treatments, and some preliminary results are useful for deciding which treatment is best for which patient, the development of personalized treatment of depression has only just begun.
关键词antidepressants clinical trials depression dysthymic disorder treatment
学科领域Personality Psychology,Cognitive Neuroscience
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收录类别SSCI
语种英语
WOS记录号WOS:000309394600004
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12893
专题中国科学院心理健康重点实验室
通讯作者Cuijpers, P (reprint author), Vrije Univ Amsterdam, Dept Clin Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
作者单位1.Vrije Univ Amsterdam, Dept Clin Psychol, NL-1081 BT Amsterdam, Netherlands
2.Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands
3.Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
5.Linkoping Univ, Swedish Inst Disabil Res, Dept Behav Sci & Learning, S-58183 Linkoping, Sweden
6.Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, Stockholm, Sweden
7.Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Psychiat, Amsterdam, Netherlands
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GB/T 7714
Cuijpers, Pim,Reynolds, Charles F., III,Donker, Tara,et al. PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW[J]. DEPRESSION AND ANXIETY,2012,29(10):855-864.
APA Cuijpers, Pim.,Reynolds, Charles F., III.,Donker, Tara.,Li, Juan.,Andersson, Gerhard.,...&Cuijpers, P .(2012).PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW.DEPRESSION AND ANXIETY,29(10),855-864.
MLA Cuijpers, Pim,et al."PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW".DEPRESSION AND ANXIETY 29.10(2012):855-864.
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