PSYCH OpenIR  > 脑与认知科学国家重点实验室
Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients
Wang, Jiawan1; Su, Tao2,3; Liu, Ying2; Yue, Yun1; He, Rongqiao2,4; Yue, Y (reprint author), Capital Med Univ, Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China.
2012-10-01
Source PublicationNEUROCHEMICAL RESEARCH
ISSN0364-3190
SubtypeArticle
Volume37Issue:10Pages:2125-2134
Contribution Rank2
AbstractPost-operative cognitive dysfunction (POCD), especially in elderly patients, has been reported in many studies. Although increasing age, duration of anesthesia, postoperative infections, and respiratory complications were regarded as the risk factors for POCD, no extracerebral diagnostic biomarkers have been identified as indicators of POCD. Ninety-five patients, ages 65-80 years, scheduled for major orthopedic or abdominal surgery were enrolled. Twenty-two patients aged between 20 and 40 years undergoing the same procedures served as controls. Subjects received neuropsychological tests one-day prior and one week post procedure. To determine the presence of POCD, the criteria were used as described in most previous studies. Morning urine samples were obtained one day before surgery and on day 1, day 2 and day 7 post operatively. Urine formaldehyde was determined with high-performance liquid chromatography. The urine formaldehyde level of all patients with and without POCD increased on the first 2 days after surgery. But the formaldehyde concentration (on day 7) in patients with POCD was significantly higher than that in patients without POCD (p < 0.01). In the young control group, no patient was diagnosed with POCD. Although the changes in urine formaldehyde of young patients during perioperative period were similar to those in elderly patients without POCD, the formaldehyde concentrations measured at four time points were all significantly lower than those in elderly patients (p < 0.05). Levels of urine formaldehyde were elevated in the perioperative period, with the highest levels at day 7 in patients with POCD. This suggests that the increase on day 7 may provide a new physiologic marker along with neuropsychological assessments to assist in the diagnosis of POCD.
KeywordUrine formaldehyde Post-operative cognitive dysfunction (POCD) Biomarkers
Subject AreaPsychology Of Old Age,Medical Psychology
URL查看原文
Indexed BySCI
Language英语
Funding Organization973-Project [2012CB911004, 2010CB912303] ; Natural Science Foundation of China [NSFC 30970695, CAS-KSCX2-YW-R-119, KSCX2-YW-R-256]
Project Intro.This work was supported by grants from the 973-Project (2012CB911004; 2010CB912303), and the Natural Science Foundation of China (NSFC 30970695 and CAS-KSCX2-YW-R-119, KSCX2-YW-R-256). We thank Dr. Jing Lu and Mr. Yingge He for providing their epidemiological investigation data to support this work and Dr. Joy Fleming for her comments on the manuscript. Dr. Joy Fleming, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
WOS IDWOS:000308701200008
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12897
Collection脑与认知科学国家重点实验室
Corresponding AuthorYue, Y (reprint author), Capital Med Univ, Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China.
Affiliation1.Capital Med Univ, Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China
2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jiawan,Su, Tao,Liu, Ying,et al. Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients[J]. NEUROCHEMICAL RESEARCH,2012,37(10):2125-2134.
APA Wang, Jiawan,Su, Tao,Liu, Ying,Yue, Yun,He, Rongqiao,&Yue, Y .(2012).Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients.NEUROCHEMICAL RESEARCH,37(10),2125-2134.
MLA Wang, Jiawan,et al."Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients".NEUROCHEMICAL RESEARCH 37.10(2012):2125-2134.
Files in This Item:
File Name/Size DocType Version Access License
WOS_000308701200008.(319KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Jiawan]'s Articles
[Su, Tao]'s Articles
[Liu, Ying]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Jiawan]'s Articles
[Su, Tao]'s Articles
[Liu, Ying]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Jiawan]'s Articles
[Su, Tao]'s Articles
[Liu, Ying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: WOS_000308701200008.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.