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Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients
Wang, Jiawan1; Su, Tao2,3; Liu, Ying2; Yue, Yun1; He, Rongqiao2,4; Yue, Y (reprint author), Capital Med Univ, Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China.
2012-10-01
发表期刊NEUROCHEMICAL RESEARCH
ISSN0364-3190
文章类型Article
卷号37期号:10页码:2125-2134
产权排序2
摘要Post-operative cognitive dysfunction (POCD), especially in elderly patients, has been reported in many studies. Although increasing age, duration of anesthesia, postoperative infections, and respiratory complications were regarded as the risk factors for POCD, no extracerebral diagnostic biomarkers have been identified as indicators of POCD. Ninety-five patients, ages 65-80 years, scheduled for major orthopedic or abdominal surgery were enrolled. Twenty-two patients aged between 20 and 40 years undergoing the same procedures served as controls. Subjects received neuropsychological tests one-day prior and one week post procedure. To determine the presence of POCD, the criteria were used as described in most previous studies. Morning urine samples were obtained one day before surgery and on day 1, day 2 and day 7 post operatively. Urine formaldehyde was determined with high-performance liquid chromatography. The urine formaldehyde level of all patients with and without POCD increased on the first 2 days after surgery. But the formaldehyde concentration (on day 7) in patients with POCD was significantly higher than that in patients without POCD (p < 0.01). In the young control group, no patient was diagnosed with POCD. Although the changes in urine formaldehyde of young patients during perioperative period were similar to those in elderly patients without POCD, the formaldehyde concentrations measured at four time points were all significantly lower than those in elderly patients (p < 0.05). Levels of urine formaldehyde were elevated in the perioperative period, with the highest levels at day 7 in patients with POCD. This suggests that the increase on day 7 may provide a new physiologic marker along with neuropsychological assessments to assist in the diagnosis of POCD.
关键词Urine formaldehyde Post-operative cognitive dysfunction (POCD) Biomarkers
学科领域Psychology Of Old Age,Medical Psychology
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收录类别SCI
语种英语
项目资助者973-Project [2012CB911004, 2010CB912303] ; Natural Science Foundation of China [NSFC 30970695, CAS-KSCX2-YW-R-119, KSCX2-YW-R-256]
项目简介This work was supported by grants from the 973-Project (2012CB911004; 2010CB912303), and the Natural Science Foundation of China (NSFC 30970695 and CAS-KSCX2-YW-R-119, KSCX2-YW-R-256). We thank Dr. Jing Lu and Mr. Yingge He for providing their epidemiological investigation data to support this work and Dr. Joy Fleming for her comments on the manuscript. Dr. Joy Fleming, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
WOS记录号WOS:000308701200008
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12897
专题脑与认知科学国家重点实验室
通讯作者Yue, Y (reprint author), Capital Med Univ, Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China.
作者单位1.Capital Med Univ, Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China
2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Wang, Jiawan,Su, Tao,Liu, Ying,et al. Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients[J]. NEUROCHEMICAL RESEARCH,2012,37(10):2125-2134.
APA Wang, Jiawan,Su, Tao,Liu, Ying,Yue, Yun,He, Rongqiao,&Yue, Y .(2012).Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients.NEUROCHEMICAL RESEARCH,37(10),2125-2134.
MLA Wang, Jiawan,et al."Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients".NEUROCHEMICAL RESEARCH 37.10(2012):2125-2134.
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