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Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources
Chang, Suhua1,2; Zhang, Weina1,2; Gao, Lei1,2; Wang, Jing1; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012-07-01
发表期刊PROTEIN & CELL
ISSN1674-800X
文章类型Article
卷号3期号:7页码:526-534
产权排序1
摘要Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder characterized by hyperactivity, inattention and increased im-pulsivity. In recent years, a large number of genetic studies for ADHD have been published and related genetic data has been accumulated dramatically. To provide researchers a comprehensive ADHD genetic resource, we previously developed the first genetic database for ADHD (ADHDgene). The abundant genetic data provides novel candidates for further study. Meanwhile, it also brings new challenge for selecting promising candidate genes for replication and verification research. In this study, we surveyed the computational tools for candidate gene prioritization and selected five tools, which integrate multiple data sources for gene prioritization, to prioritize ADHD candidate genes in ADHDgene. The prioritization analysis resulted in 16 prioritized candidate genes, which are mainly involved in several major neurotransmitter systems or in nervous system development pathways. Among these genes, nervous system development related genes, especially SNAP25, STX1A and the gene-gene interactions related with each of them deserve further investigations. Our results may provide new insight for further verification study and facilitate the exploration of pathogenesis mechanism of ADHD.
关键词gene prioritization attention deficit hyperactivity disorder candidate genes multiple data sources
学科领域Cognitive Psychology
收录类别SCI
语种英语
项目资助者Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This work was supported by Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号WOS:000310531200007
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12902
专题中国科学院心理健康重点实验室
通讯作者Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
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Chang, Suhua,Zhang, Weina,Gao, Lei,et al. Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources[J]. PROTEIN & CELL,2012,3(7):526-534.
APA Chang, Suhua,Zhang, Weina,Gao, Lei,Wang, Jing,&Wang, J .(2012).Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources.PROTEIN & CELL,3(7),526-534.
MLA Chang, Suhua,et al."Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources".PROTEIN & CELL 3.7(2012):526-534.
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