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Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources
Chang, Suhua1,2; Zhang, Weina1,2; Gao, Lei1,2; Wang, Jing1; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Contribution Rank1
AbstractAttention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder characterized by hyperactivity, inattention and increased im-pulsivity. In recent years, a large number of genetic studies for ADHD have been published and related genetic data has been accumulated dramatically. To provide researchers a comprehensive ADHD genetic resource, we previously developed the first genetic database for ADHD (ADHDgene). The abundant genetic data provides novel candidates for further study. Meanwhile, it also brings new challenge for selecting promising candidate genes for replication and verification research. In this study, we surveyed the computational tools for candidate gene prioritization and selected five tools, which integrate multiple data sources for gene prioritization, to prioritize ADHD candidate genes in ADHDgene. The prioritization analysis resulted in 16 prioritized candidate genes, which are mainly involved in several major neurotransmitter systems or in nervous system development pathways. Among these genes, nervous system development related genes, especially SNAP25, STX1A and the gene-gene interactions related with each of them deserve further investigations. Our results may provide new insight for further verification study and facilitate the exploration of pathogenesis mechanism of ADHD.
Keywordgene prioritization attention deficit hyperactivity disorder candidate genes multiple data sources
Subject AreaCognitive Psychology
2012-07-01
Language英语
Source PublicationPROTEIN & CELL
ISSN1674-800X
Volume3Issue:7Pages:526-534
SubtypeArticle
Indexed BySCI
Project Intro.This work was supported by Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS IDWOS:000310531200007
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12902
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chang, Suhua,Zhang, Weina,Gao, Lei,et al. Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources[J]. PROTEIN & CELL,2012,3(7):526-534.
APA Chang, Suhua,Zhang, Weina,Gao, Lei,Wang, Jing,&Wang, J .(2012).Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources.PROTEIN & CELL,3(7),526-534.
MLA Chang, Suhua,et al."Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources".PROTEIN & CELL 3.7(2012):526-534.
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