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Prospective memory in patients with first-onset schizophrenia and their non-psychotic siblings
Lui, Simon S. Y.1,2,3; Wang, Ya1; Liu, Amy C. Y.3; Chui, William W. H.3; Gong, Qi-yong4; Shum, David5,6; Cheung, Eric F. C.3; Chan, Raymond C. K.1; Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, 4A Datun Rd, Beijing 100101, Peoples R China.
2011-07-01
发表期刊NEUROPSYCHOLOGIA
ISSN0028-3932
文章类型Article
卷号49期号:8页码:2217-2224
产权排序1
摘要This behavioral study used a dual-task paradigm to compare PM performance in 35 patients with first-onset schizophrenia, 40 non-psychotic siblings and 35 healthy controls. It aimed specifically to examine the effect of schizophrenia group status on PM, the differential effect of group status on PM type, and correlations between PM and other neurocognitive functions and clinical data in first-onset schizophrenia. It also aimed to test the hypothesis that non-psychotic siblings had poorer PM performance than controls. The cohort of first-onset schizophrenia patients had relatively short illness durations (M=1.7 years). The three groups of participants were matched in terms of age, gender and years of education. Results of the study confirmed that first-onset schizophrenia status had a primary effect on PM after controlling for other neurocognitive functions. We also found that first-onset schizophrenia status did not differentially affect two different types of PM. In the first-onset schizophrenia cohort, PM was found to correlate significantly with IQ executive functions and sustained attention. Finally, contrary to the findings of the previous study, this study did not find siblings of schizophrenia patients to have impaired PM. Taking into account the previous findings of PM in chronic schizophrenia, we concluded that schizophrenia has a primary effect on PM regardless of illness duration. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Prospective memory First-onset schizophrenia Non-psychotic siblings
学科领域Abnormal Psychology
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收录类别SSCI
语种英语
项目资助者Project-Oriented Hundred Talents Programme [O7CX031003] ; Chinese Academy of Sciences [KSCX2-YW-R-131, KSCX2-EW-J-8] ; National Science Fund China [30770723, 81088001] ; National Basic Research Programme (973 Programme) [2007CB512302/5] ; Australian Academy of Science
项目简介This study was supported partially by the Project-Oriented Hundred Talents Programme (O7CX031003), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131 & KSCX2-EW-J-8), a grant from the National Science Fund China (30770723), the National Basic Research Programme (973 Programme No. 2007CB512302/5), and the National Science Fund China Young Investigator Award (81088001) to Raymond Chan. It was also supported by an Australian Academy of Science, Scientific Visits to China Grant to David Shum.
WOS记录号WOS:000292805700009
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12905
专题中国科学院心理健康重点实验室
通讯作者Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
4.Sichuan Univ, W China Sch Med, W China Hosp, Huaxi MR Res Ctr,Dept Radiol, Chengdu 610064, Peoples R China
5.Griffith Univ, Sch Psychol, Brisbane, Qld 4111, Australia
6.Griffith Univ, Griffith Hlth Inst, Brisbane, Qld 4111, Australia
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Lui, Simon S. Y.,Wang, Ya,Liu, Amy C. Y.,et al. Prospective memory in patients with first-onset schizophrenia and their non-psychotic siblings[J]. NEUROPSYCHOLOGIA,2011,49(8):2217-2224.
APA Lui, Simon S. Y..,Wang, Ya.,Liu, Amy C. Y..,Chui, William W. H..,Gong, Qi-yong.,...&Chan, RCK .(2011).Prospective memory in patients with first-onset schizophrenia and their non-psychotic siblings.NEUROPSYCHOLOGIA,49(8),2217-2224.
MLA Lui, Simon S. Y.,et al."Prospective memory in patients with first-onset schizophrenia and their non-psychotic siblings".NEUROPSYCHOLOGIA 49.8(2011):2217-2224.
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