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Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats
Liu, Zhenquan2; Li, Pengtao2; Zhao, Dan2; Tang, Huiling2; Guo, Jianyou1; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012
Source PublicationBIOLOGICAL TRACE ELEMENT RESEARCH
ISSN0163-4984
SubtypeArticle
Volume145Issue:1Pages:66-70
Contribution Rank2
AbstractThere is now substantial epidemiological evidence that diabetes is a risk factor for cerebrovascular disease. The protection by vanadium from focal cerebral ischemia in diabetic rats was studied in this paper. Rats with streptozotocin-induced diabetes were subjected to middle cerebral artery occlusion followed by 4 weeks of administration of 0.6 mg/ml sodium orthovanadate in drinking water. Vanadium significantly improved the outcome in diabetic rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. Vanadium reduces brain damage in streptozotocin-induced diabetic rats by imitating action of insulin.
KeywordVanadium Diabetes Focal cerebral ischemia Insulin Cerebrovascular disease
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationMinistry of Science and Technology [2009ZX09502-017] ; Program for New Century Excellent Talents in University [NCET-10-0273] ; Beijing Nova Program [2010B035] ; Key Laboratory of Mental Health ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; IPCAS [08CX043004] ; NNSF [30800301]
Project Intro.This work was supported by the Key New Drugs Innovation project from Ministry of Science and Technology (2009ZX09502-017), Program for New Century Excellent Talents in University (NCET-10-0273), Beijing Nova Program (2010B035), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, Young Scientist project from IPCAS (08CX043004), NNSF grant (30800301), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS IDWOS:000299090300009
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12906
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100102, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhenquan,Li, Pengtao,Zhao, Dan,et al. Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2012,145(1):66-70.
APA Liu, Zhenquan,Li, Pengtao,Zhao, Dan,Tang, Huiling,Guo, Jianyou,&Guo, JY .(2012).Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats.BIOLOGICAL TRACE ELEMENT RESEARCH,145(1),66-70.
MLA Liu, Zhenquan,et al."Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats".BIOLOGICAL TRACE ELEMENT RESEARCH 145.1(2012):66-70.
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