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Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats
Liu, Zhenquan2; Li, Pengtao2; Zhao, Dan2; Tang, Huiling2; Guo, Jianyou1; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012
发表期刊BIOLOGICAL TRACE ELEMENT RESEARCH
ISSN0163-4984
文章类型Article
卷号145期号:1页码:66-70
产权排序2
摘要There is now substantial epidemiological evidence that diabetes is a risk factor for cerebrovascular disease. The protection by vanadium from focal cerebral ischemia in diabetic rats was studied in this paper. Rats with streptozotocin-induced diabetes were subjected to middle cerebral artery occlusion followed by 4 weeks of administration of 0.6 mg/ml sodium orthovanadate in drinking water. Vanadium significantly improved the outcome in diabetic rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. Vanadium reduces brain damage in streptozotocin-induced diabetic rats by imitating action of insulin.
关键词Vanadium Diabetes Focal cerebral ischemia Insulin Cerebrovascular disease
学科领域Medical Psychology
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收录类别SCI
语种英语
项目资助者Ministry of Science and Technology [2009ZX09502-017] ; Program for New Century Excellent Talents in University [NCET-10-0273] ; Beijing Nova Program [2010B035] ; Key Laboratory of Mental Health ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; IPCAS [08CX043004] ; NNSF [30800301]
项目简介This work was supported by the Key New Drugs Innovation project from Ministry of Science and Technology (2009ZX09502-017), Program for New Century Excellent Talents in University (NCET-10-0273), Beijing Nova Program (2010B035), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, Young Scientist project from IPCAS (08CX043004), NNSF grant (30800301), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS记录号WOS:000299090300009
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/12906
专题中国科学院心理健康重点实验室
通讯作者Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100102, Peoples R China
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Liu, Zhenquan,Li, Pengtao,Zhao, Dan,et al. Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2012,145(1):66-70.
APA Liu, Zhenquan,Li, Pengtao,Zhao, Dan,Tang, Huiling,Guo, Jianyou,&Guo, JY .(2012).Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats.BIOLOGICAL TRACE ELEMENT RESEARCH,145(1),66-70.
MLA Liu, Zhenquan,et al."Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats".BIOLOGICAL TRACE ELEMENT RESEARCH 145.1(2012):66-70.
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