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Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety
Zhou, Wen2; Hou, Ping3,4; Zhou, Yuxiang3; Chen, Denise1; Chen, D (reprint author), Rice Univ, Dept Psychol MS 25, 6100 Main St, Houston, TX 77005 USA.
2011-04-01
Source PublicationNEUROIMAGE
ISSN1053-8119
SubtypeArticle
Volume55Issue:3Pages:1401-1406
Contribution Rank1
AbstractSocial anxiety refers to the prevalent and debilitating experience of fear and anxiety of being scrutinized in social situations. It originates from both learned (e.g. adverse social conditioning) and innate (e.g. shyness) factors. Research on social anxiety has traditionally focused on negative emotions induced by visual and auditory social cues in socially anxious clinical populations, and posits a dysfunctional orbitofrontal-amygdala circuit as a primary etiological mechanism. Yet as a trait, social anxiety is independent of one's specific emotional state. Here we probe the neural substrate of intrinsic social anxiety by employing a unique type of social stimuli, airborne human social chemosensory cues that are inherently social, ubiquitously present, and yet operating below verbal awareness. We show that the adopted social chemosensory cues were not perceived to be human-related, did not differentially bias self-report of anxiety or autonomic nervous system responses, yet individuals with elevated social anxiety demonstrated a reduced recruitment of the orbitofrontal cortex to social chemosensory cues. No reciprocal activity in the amygdala was observed. Our findings point to an intrinsic neural substrate underlying social anxiety that is not associated with prior adverse social conditioning, thereby providing the first neural evidence for the inherent social aspect of this enigmatic phenomenon. (C) 2011 Elsevier Inc. All rights reserved.
Subject AreaEmotional Psychology,social Psychology
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Indexed BySCI ; SSCI
Language英语
Funding OrganizationNIH [R03 DC4956] ; NCRR/NIH [S10RR19186-01]
Project Intro.This work was supported by NIH R03 DC4956. The purchase of the MRI scanner was partially funded by NCRR/NIH grant # S10RR19186-01. We thank Vips Patel for the assistance with fMRI data collection, and Jay Gottfried, Wen Li, Gang Chen, Michael S. Beauchamp for helpful discussions.
WOS IDWOS:000288313800052
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12911
Collection中国科学院心理健康重点实验室
Corresponding AuthorChen, D (reprint author), Rice Univ, Dept Psychol MS 25, 6100 Main St, Houston, TX 77005 USA.
Affiliation1.Rice Univ, Dept Psychol MS 25, Houston, TX 77005 USA
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Texas Med Sch Houston, Dept Diagnost & Intervent Imaging, Houston, TX 77030 USA
4.Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhou, Wen,Hou, Ping,Zhou, Yuxiang,et al. Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety[J]. NEUROIMAGE,2011,55(3):1401-1406.
APA Zhou, Wen,Hou, Ping,Zhou, Yuxiang,Chen, Denise,&Chen, D .(2011).Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety.NEUROIMAGE,55(3),1401-1406.
MLA Zhou, Wen,et al."Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety".NEUROIMAGE 55.3(2011):1401-1406.
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