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Resting-State Brain Activity in Adult Males Who Stutter
Xuan, Yun1; Meng, Chun2; Yang, Yanhui3; Zhu, Chaozhe2; Wang, Liang4; Yan, Qian5; Lin, Chunlan6; Yu, Chunshui4; Xuan, Y (reprint author), Tianjin Med Univ, Dept Anat, Tianjin, Peoples R China.
Source PublicationPLOS ONE
Contribution Rank5
AbstractAlthough developmental stuttering has been extensively studied with structural and task-based functional magnetic resonance imaging (fMRI), few studies have focused on resting-state brain activity in this disorder. We investigated resting-state brain activity of stuttering subjects by analyzing the amplitude of low-frequency fluctuation (ALFF), region of interest (ROI)-based functional connectivity (FC) and independent component analysis (ICA)-based FC. Forty-four adult males with developmental stuttering and 46 age-matched fluent male controls were scanned using resting-state fMRI. ALFF, ROI-based FCs and ICA-based FCs were compared between male stuttering subjects and fluent controls in a voxel-wise manner. Compared with fluent controls, stuttering subjects showed increased ALFF in left brain areas related to speech motor and auditory functions and bilateral prefrontal cortices related to cognitive control. However, stuttering subjects showed decreased ALFF in the left posterior language reception area and bilateral non-speech motor areas. ROI-based FC analysis revealed decreased FC between the posterior language area involved in the perception and decoding of sensory information and anterior brain area involved in the initiation of speech motor function, as well as increased FC within anterior or posterior speech-and language-associated areas and between the prefrontal areas and default-mode network (DMN) in stuttering subjects. ICA showed that stuttering subjects had decreased FC in the DMN and increased FC in the sensorimotor network. Our findings support the concept that stuttering subjects have deficits in multiple functional systems (motor, language, auditory and DMN) and in the connections between them.
Subject AreaPhysiological Psychology/biological Psychology
Indexed BySCI
Funding OrganizationNatural Science Foundation of China [30870694] ; Program for New Century Excellent Talents in University [NCET-07-0568]
Project Intro.This work was supported by Natural Science Foundation of China, 30870694; and Program for New Century Excellent Talents in University, NCET-07-0568. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS IDWOS:000301568100057
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Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorXuan, Y (reprint author), Tianjin Med Univ, Dept Anat, Tianjin, Peoples R China.
Affiliation1.Tianjin Med Univ, Dept Anat, Tianjin, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
4.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
6.Beijing Prof Lin Stuttering Correct Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Xuan, Yun,Meng, Chun,Yang, Yanhui,et al. Resting-State Brain Activity in Adult Males Who Stutter[J]. PLOS ONE,2012,7(1).
APA Xuan, Yun.,Meng, Chun.,Yang, Yanhui.,Zhu, Chaozhe.,Wang, Liang.,...&Xuan, Y .(2012).Resting-State Brain Activity in Adult Males Who Stutter.PLOS ONE,7(1).
MLA Xuan, Yun,et al."Resting-State Brain Activity in Adult Males Who Stutter".PLOS ONE 7.1(2012).
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