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Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex
Tian, Weiping1; Zhao, Mei2; Li, Min5; Song, Tianbao1; Zhang, Min3; Quan, Li3; Li, Shengbin1; Sun, Zhong Sheng4,5; Tian, WP (reprint author), Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710049, Shanxi, Peoples R China.
2012-03-16
发表期刊PLOS ONE
ISSN1932-6203
文章类型Article
卷号7期号:3
产权排序2
摘要Analysis of global methylation in cells has revealed correlations between overall DNA methylation status and some biological states. Recent studies suggest that epigenetic regulation through DNA methylation could be responsible for neuroadaptations induced by addictive drugs. However, there is no investigation to determine global DNA methylation status following repeated exposure to addictive drugs. Using mice conditioned place preference (CPP) procedure, we measured global DNA methylation level in the nucleus accumbens (NAc) and the prefrontal cortex (PFC) associated with drug rewarding effects. We found that cocaine-, but not morphine- or food-CPP training decreased global DNA methylation in the PFC. Chronic treatment with methionine, a methyl donor, for 25 consecutive days prior to and during CPP training inhibited the establishment of cocaine, but not morphine or food CPP. We also found that both mRNA and protein level of DNMT (DNA methytransferase) 3b in the PFC were downregulated following the establishment of cocaine CPP, and the downregulation could be reversed by repeated administration of methionine. Our study indicates a crucial role of global PFC DNA hypomethylation in the rewarding effects of cocaine. Reversal of global DNA hypomethylation could significantly attenuate the rewarding effects induced by cocaine. Our results suggest that methionine may have become a potential therapeutic target to treat cocaine addiction.
学科领域Physiological Psychology/biological Psychology
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收录类别SCI
语种英语
项目资助者Natural Science Foundation of China [30870821, 81071078] ; Institute of Psychology and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This work was supported by Natural Science Foundation of China Grants (30870821 and 81071078), Youth Development Funding (O9KF015001) from the Institute of Psychology and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS记录号WOS:000303309100045
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13248
专题中国科学院心理健康重点实验室
通讯作者Tian, WP (reprint author), Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710049, Shanxi, Peoples R China.
作者单位1.Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710049, Shanxi, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Capital Inst Pediat, Dept Mol Immunol, Beijing, Peoples R China
4.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China
5.Wenzhou Med Coll, Inst Genom Med, Wenzhou, Peoples R China
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Tian, Weiping,Zhao, Mei,Li, Min,et al. Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex[J]. PLOS ONE,2012,7(3).
APA Tian, Weiping.,Zhao, Mei.,Li, Min.,Song, Tianbao.,Zhang, Min.,...&Tian, WP .(2012).Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex.PLOS ONE,7(3).
MLA Tian, Weiping,et al."Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex".PLOS ONE 7.3(2012).
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