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Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex
Tian, Weiping1; Zhao, Mei2; Li, Min5; Song, Tianbao1; Zhang, Min3; Quan, Li3; Li, Shengbin1; Sun, Zhong Sheng4,5; Tian, WP (reprint author), Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710049, Shanxi, Peoples R China.
2012-03-16
Source PublicationPLOS ONE
ISSN1932-6203
SubtypeArticle
Volume7Issue:3
Contribution Rank2
AbstractAnalysis of global methylation in cells has revealed correlations between overall DNA methylation status and some biological states. Recent studies suggest that epigenetic regulation through DNA methylation could be responsible for neuroadaptations induced by addictive drugs. However, there is no investigation to determine global DNA methylation status following repeated exposure to addictive drugs. Using mice conditioned place preference (CPP) procedure, we measured global DNA methylation level in the nucleus accumbens (NAc) and the prefrontal cortex (PFC) associated with drug rewarding effects. We found that cocaine-, but not morphine- or food-CPP training decreased global DNA methylation in the PFC. Chronic treatment with methionine, a methyl donor, for 25 consecutive days prior to and during CPP training inhibited the establishment of cocaine, but not morphine or food CPP. We also found that both mRNA and protein level of DNMT (DNA methytransferase) 3b in the PFC were downregulated following the establishment of cocaine CPP, and the downregulation could be reversed by repeated administration of methionine. Our study indicates a crucial role of global PFC DNA hypomethylation in the rewarding effects of cocaine. Reversal of global DNA hypomethylation could significantly attenuate the rewarding effects induced by cocaine. Our results suggest that methionine may have become a potential therapeutic target to treat cocaine addiction.
Subject AreaPhysiological Psychology/biological Psychology
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Indexed BySCI
Language英语
Funding OrganizationNatural Science Foundation of China [30870821, 81071078] ; Institute of Psychology and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Project Intro.This work was supported by Natural Science Foundation of China Grants (30870821 and 81071078), Youth Development Funding (O9KF015001) from the Institute of Psychology and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS IDWOS:000303309100045
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Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13248
Collection中国科学院心理健康重点实验室
Corresponding AuthorTian, WP (reprint author), Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710049, Shanxi, Peoples R China.
Affiliation1.Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710049, Shanxi, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Capital Inst Pediat, Dept Mol Immunol, Beijing, Peoples R China
4.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China
5.Wenzhou Med Coll, Inst Genom Med, Wenzhou, Peoples R China
Recommended Citation
GB/T 7714
Tian, Weiping,Zhao, Mei,Li, Min,et al. Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex[J]. PLOS ONE,2012,7(3).
APA Tian, Weiping.,Zhao, Mei.,Li, Min.,Song, Tianbao.,Zhang, Min.,...&Tian, WP .(2012).Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex.PLOS ONE,7(3).
MLA Tian, Weiping,et al."Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex".PLOS ONE 7.3(2012).
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