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Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits
Donges, B.1,2; Haupt, L. M.1,2; Lea, R. A.1,2; Chan, R. C. K.5; Shum, D. H. K.3,4; Griffiths, L. R.1,2; Griffiths, LR (reprint author), Griffith Univ, Griffith Hlth Inst, Genom Res Ctr, Gold Coast, Qld 4222, Australia.
2012-09-10
发表期刊GENE
ISSN0378-1119
文章类型Article
卷号506期号:1页码:135-140
产权排序3
摘要Human memory is a complex neurocognitive process. By combining psychological and molecular genetics expertise, we examined the APOE epsilon 4 allele, a known risk factor for Alzheimer's disease, and the COMT Val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults. To assess memory type we used a range of memory tests of both retrospective and prospective memory. Genotypes were determined using RFLP analysis and compared with mean memory scores using univariate ANOVAs. Despite a modest sample size (n = 197), our study found a significant effect of the APOE epsilon 4 polymorphism in prospective memory. Supporting our hypothesis, a significant difference was demonstrated between genotype groups for means of the Comprehensive Assessment of Prospective Memory total score (p = 0.036; epsilon 4 alleles = 1.99; all other alleles = 1.86). In addition, we demonstrate a significant interactive effect between the APOE epsilon 4 and COMT polymorphisms in semantic memory. This is the first study to investigate both APOE and COMT genotypes in relation to memory in non-pathological adults and provides important information regarding the effect of genetic determinants on human memory. (C) 2012 Elsevier B.V. All rights reserved.
关键词Prospective memory Retrospective memory Genetics of memory APOE COMT
学科领域Cognitive Psychology
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收录类别SCI
语种英语
WOS记录号WOS:000308260400019
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13251
专题中国科学院心理健康重点实验室
通讯作者Griffiths, LR (reprint author), Griffith Univ, Griffith Hlth Inst, Genom Res Ctr, Gold Coast, Qld 4222, Australia.
作者单位1.Griffith Univ, Griffith Hlth Inst, Genom Res Ctr, Gold Coast, Qld 4222, Australia
2.Griffith Univ, Sch Med Sci, Gold Coast, Qld 4222, Australia
3.Griffith Univ, Sch Appl Psychol, Gold Coast, Qld 4222, Australia
4.Griffith Univ, Behav Basis Hlth Program, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
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Donges, B.,Haupt, L. M.,Lea, R. A.,et al. Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits[J]. GENE,2012,506(1):135-140.
APA Donges, B..,Haupt, L. M..,Lea, R. A..,Chan, R. C. K..,Shum, D. H. K..,...&Griffiths, LR .(2012).Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits.GENE,506(1),135-140.
MLA Donges, B.,et al."Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits".GENE 506.1(2012):135-140.
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