Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits

	Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits
	Donges, B.1,2; Haupt, L. M.1,2; Lea, R. A.1,2; Chan, R. C. K.5 ; Shum, D. H. K.3,4; Griffiths, L. R.1,2; Griffiths, LR (reprint author), Griffith Univ, Griffith Hlth Inst, Genom Res Ctr, Gold Coast, Qld 4222, Australia.
心理所单位排序	3
摘要	Human memory is a complex neurocognitive process. By combining psychological and molecular genetics expertise, we examined the APOE epsilon 4 allele, a known risk factor for Alzheimer's disease, and the COMT Val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults. To assess memory type we used a range of memory tests of both retrospective and prospective memory. Genotypes were determined using RFLP analysis and compared with mean memory scores using univariate ANOVAs. Despite a modest sample size (n = 197), our study found a significant effect of the APOE epsilon 4 polymorphism in prospective memory. Supporting our hypothesis, a significant difference was demonstrated between genotype groups for means of the Comprehensive Assessment of Prospective Memory total score (p = 0.036; epsilon 4 alleles = 1.99; all other alleles = 1.86). In addition, we demonstrate a significant interactive effect between the APOE epsilon 4 and COMT polymorphisms in semantic memory. This is the first study to investigate both APOE and COMT genotypes in relation to memory in non-pathological adults and provides important information regarding the effect of genetic determinants on human memory. (C) 2012 Elsevier B.V. All rights reserved.
关键词	Prospective memory Retrospective memory Genetics of memory APOE COMT
学科领域	Cognitive Psychology
	2012-09-10
语种	英语
发表期刊	GENE
ISSN	0378-1119
卷号	506 期号:1 页码:135-140
期刊论文类型	Article
URL	查看原文
收录类别	SCI
WOS记录号	WOS:000308260400019
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13251
专题	中国科学院心理健康重点实验室
通讯作者	Griffiths, LR (reprint author), Griffith Univ, Griffith Hlth Inst, Genom Res Ctr, Gold Coast, Qld 4222, Australia.
作者单位	1.Griffith Univ, Griffith Hlth Inst, Genom Res Ctr, Gold Coast, Qld 4222, Australia 2.Griffith Univ, Sch Med Sci, Gold Coast, Qld 4222, Australia 3.Griffith Univ, Sch Appl Psychol, Gold Coast, Qld 4222, Australia 4.Griffith Univ, Behav Basis Hlth Program, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Donges, B.,Haupt, L. M.,Lea, R. A.,et al. Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits[J]. GENE,2012,506(1):135-140.
APA	Donges, B..,Haupt, L. M..,Lea, R. A..,Chan, R. C. K..,Shum, D. H. K..,...&Griffiths, LR .(2012).Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits.GENE,506(1),135-140.
MLA	Donges, B.,et al."Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits".GENE 506.1(2012):135-140.

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