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Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization
Liang, Jing1; Zheng, Xigeng1; Chen, Jihuan2; Li, Yingying1,3; Xing, Xiaoli1,3; Bai, Yunjing1; Li, Yingcong1; Zheng, XG (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011-11-01
发表期刊EUROPEAN NEUROPSYCHOPHARMACOLOGY
ISSN0924-977X
文章类型Article
卷号21期号:11页码:825-834
产权排序1
摘要Drug seeking, craving, and relapse can be triggered by environmental stimuli that acquire motivational salience through repeated associations with the drug's effects. Previous studies indicated that the dopamine D-3 receptor (Drd3) might be involved in the expression of drug-conditioned responses in rats, and brain-derived neurotrophic factor (BDNF) could modulate Drd3 expression in the nucleus accumbens (NAc). However, the involvement of neural regions with Drd3 activation and the underlying interaction between BDNF and Drd3 in the expression of behavioral responses controlled by a drug-associated environment have remained poorly understood. The present study used a conditioning procedure to assess the roles of BDNF, Drd3, and their interactions in the NAc in the expression of morphine-induced context-specific locomotor sensitization. We showed that the expression of locomotor sensitization in the morphine-paired environment was accompanied by significantly increased expression of Drd3 mRNA and BDNF mRNA and protein levels. Both sensitized locomotion in morphine-paired rats and enhanced Drd3 mRNA were suppressed by intra-NAc infusion of anti-tyrosine kinase receptor B (TrkB) IgG. Furthermore, intra-NAc infusion of the Drd3-selective antagonist SB-277011A significantly decreased the expression of context-specific locomotor sensitization and upregulated BDNF mRNA. Altogether, these results suggest that BDNF/TrkB signaling and activation of Drd3 in the NAc are required for the expression of morphine-induced context-specific locomotor sensitization. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.
关键词BDNF Dopamine D-3 receptor Morphine Nucleus accumbens Sensitization
学科领域Cognitive Neuroscience
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收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [30900400, 30770722] ; National Basic Research Program of China [2009CB522002] ; Institute of Psychology, Chinese Academy of Sciences [08CX053005]
项目简介This work was supported by grants from the National Natural Science Foundation of China (30900400, 30770722), the National Basic Research Program of China (2009CB522002) and the Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (08CX053005). These grants had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
WOS记录号WOS:000296683300006
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13252
专题中国科学院心理健康重点实验室
通讯作者Zheng, XG (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Liang, Jing,Zheng, Xigeng,Chen, Jihuan,et al. Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2011,21(11):825-834.
APA Liang, Jing.,Zheng, Xigeng.,Chen, Jihuan.,Li, Yingying.,Xing, Xiaoli.,...&Zheng, XG .(2011).Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization.EUROPEAN NEUROPSYCHOPHARMACOLOGY,21(11),825-834.
MLA Liang, Jing,et al."Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization".EUROPEAN NEUROPSYCHOPHARMACOLOGY 21.11(2011):825-834.
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