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Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization
Liang, Jing1; Zheng, Xigeng1; Chen, Jihuan2; Li, Yingying1,3; Xing, Xiaoli1,3; Bai, Yunjing1; Li, Yingcong1; Zheng, XG (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011-11-01
Source PublicationEUROPEAN NEUROPSYCHOPHARMACOLOGY
ISSN0924-977X
SubtypeArticle
Volume21Issue:11Pages:825-834
Contribution Rank1
AbstractDrug seeking, craving, and relapse can be triggered by environmental stimuli that acquire motivational salience through repeated associations with the drug's effects. Previous studies indicated that the dopamine D-3 receptor (Drd3) might be involved in the expression of drug-conditioned responses in rats, and brain-derived neurotrophic factor (BDNF) could modulate Drd3 expression in the nucleus accumbens (NAc). However, the involvement of neural regions with Drd3 activation and the underlying interaction between BDNF and Drd3 in the expression of behavioral responses controlled by a drug-associated environment have remained poorly understood. The present study used a conditioning procedure to assess the roles of BDNF, Drd3, and their interactions in the NAc in the expression of morphine-induced context-specific locomotor sensitization. We showed that the expression of locomotor sensitization in the morphine-paired environment was accompanied by significantly increased expression of Drd3 mRNA and BDNF mRNA and protein levels. Both sensitized locomotion in morphine-paired rats and enhanced Drd3 mRNA were suppressed by intra-NAc infusion of anti-tyrosine kinase receptor B (TrkB) IgG. Furthermore, intra-NAc infusion of the Drd3-selective antagonist SB-277011A significantly decreased the expression of context-specific locomotor sensitization and upregulated BDNF mRNA. Altogether, these results suggest that BDNF/TrkB signaling and activation of Drd3 in the NAc are required for the expression of morphine-induced context-specific locomotor sensitization. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.
KeywordBDNF Dopamine D-3 receptor Morphine Nucleus accumbens Sensitization
Subject AreaCognitive Neuroscience
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Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [30900400, 30770722] ; National Basic Research Program of China [2009CB522002] ; Institute of Psychology, Chinese Academy of Sciences [08CX053005]
Project Intro.This work was supported by grants from the National Natural Science Foundation of China (30900400, 30770722), the National Basic Research Program of China (2009CB522002) and the Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (08CX053005). These grants had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
WOS IDWOS:000296683300006
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Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13252
Collection中国科学院心理健康重点实验室
Corresponding AuthorZheng, XG (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liang, Jing,Zheng, Xigeng,Chen, Jihuan,et al. Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2011,21(11):825-834.
APA Liang, Jing.,Zheng, Xigeng.,Chen, Jihuan.,Li, Yingying.,Xing, Xiaoli.,...&Zheng, XG .(2011).Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization.EUROPEAN NEUROPSYCHOPHARMACOLOGY,21(11),825-834.
MLA Liang, Jing,et al."Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization".EUROPEAN NEUROPSYCHOPHARMACOLOGY 21.11(2011):825-834.
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