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Suppression of aversive memories associates with changes in early and late stages of neurocognitive processing
Chen, Chunping1,2; Liu, Chao1; Huang, Ruiwang1,3; Cheng, Dazhi1; Wu, Haiyan1; Xu, Pengfei1; Mai, Xiaoqin4; Luo, Yue-Jia1; Liu, C (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
2012-10-01
Source PublicationNEUROPSYCHOLOGIA
ISSN0028-3932
SubtypeArticle
Volume50Issue:12Pages:2839-2848
Contribution Rank2
AbstractUnwanted memories, such as emotionally negative, can be intentionally suppressed through voluntary control in humans. Memory suppression is thought to be mediated by the interplay of a chain of neurocognitive processes. However, empirical data in support of this notion is lacking. Using high-temporal resolution event-related potential (ERP) technique, we investigated the time course of ERPs associated with suppression of negative and neutral memories in a Think/No-Think paradigm in young, healthy participants. Results showed that participants had greater difficulty in suppressing emotionally negative memories than neutral ones. ERPs and source analyses demonstrated that memory suppression processing for negative and neutral memories were generally associated with changes during early components of a time window of 70-260 ms, such as P1 and N2, mainly at the right inferior frontal gyrus and occipital lobe; suppression of aversive memories was associated with two major late ERP components between 380 and 800 ms, with significantly smaller later negativity (LN) but larger late parietal positivity (LPP), primarily at the right medial and superior frontal gyri. These results suggest that differences in early components may reflect early stages of suppression processing including visual awareness, attention reallocation, and executive processing. Differences in late components between suppression of aversive and neutral memories may reflect a process of down-regulating conscious recollection of memory representations supported by prefrontal and parietal networks. A less effective control of this process, as evidenced by smaller LN and larger LPP, may explain the fact that emotionally negative memories were harder to be suppressed. Altogether, these findings suggest that suppression of aversive memories requires down-regulation of late conscious recollection, which can be dissociated from early visual and attention processing in memory suppression. (C) 2012 Elsevier Ltd. All rights reserved.
KeywordMemory suppression Event-related-potentials Later negativity (LN) Late parietal positivity (LPP) Think and No-Think task
Subject AreaCognitive Psychology
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Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Basic Research (973) Program [2011CB711000] ; National Natural Science Foundation of China (NSFC) [91132704, 30930031] ; National Key Technologies R D Program [2009BAI77B01] ; Global Research Initiative Program, National Institutes of Health, USA [1R01TW007897] ; NSFC [31170971]
Project Intro.We thank Dr. Shaozheng Qin and Shaw Lacy for their valuable discussions, comments and suggestions on this manuscript. This work was supported by the National Basic Research (973) Program (2011CB711000), the National Natural Science Foundation of China (NSFC) (91132704, 30930031), the National Key Technologies R & D Program (2009BAI77B01), and the Global Research Initiative Program, National Institutes of Health, USA (1R01TW007897) to YJL, and the NSFC (31170971) to CL.
WOS IDWOS:000310945900015
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Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13272
Collection中国科学院心理健康重点实验室
Corresponding AuthorLiu, C (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.S China Normal Univ, Ctr Studies Psychol Applicat, Guangdong Key Lab Mental Hlth & Cognit Sci, Guangzhou 510631, Guangdong, Peoples R China
4.Renming Univ, Dept Psychol, Beijing 100872, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chen, Chunping,Liu, Chao,Huang, Ruiwang,et al. Suppression of aversive memories associates with changes in early and late stages of neurocognitive processing[J]. NEUROPSYCHOLOGIA,2012,50(12):2839-2848.
APA Chen, Chunping.,Liu, Chao.,Huang, Ruiwang.,Cheng, Dazhi.,Wu, Haiyan.,...&Liu, C .(2012).Suppression of aversive memories associates with changes in early and late stages of neurocognitive processing.NEUROPSYCHOLOGIA,50(12),2839-2848.
MLA Chen, Chunping,et al."Suppression of aversive memories associates with changes in early and late stages of neurocognitive processing".NEUROPSYCHOLOGIA 50.12(2012):2839-2848.
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