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Systematic evaluation of genome-wide methylated DNA enrichment using a CpG island array
Yang, Liu2,3; Zhang, Kunlin1; Dai, Wei2; He, Ximiao1; Zhao, Qian1; Wang, Jing1; Sun, Zhong Sheng2; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011-01-06
发表期刊BMC GENOMICS
ISSN1471-2164
文章类型Article
卷号12
产权排序1,2
摘要Background: Recent progress in high-throughput technologies has greatly contributed to the development of DNA methylation profiling. Although there are several reports that describe methylome detection of whole genome bisulfite sequencing, the high cost and heavy demand on bioinformatics analysis prevents its extensive application. Thus, current strategies for the study of mammalian DNA methylomes is still based primarily on genome-wide methylated DNA enrichment combined with DNA microarray detection or sequencing. Methylated DNA enrichment is a key step in a microarray based genome-wide methylation profiling study, and even for future high-throughput sequencing based methylome analysis.
学科领域Physiological Psychology/biological Psychology
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收录类别SCI
语种英语
项目资助者Ministry of Science and Technology of the People's Republic of China [2006AA02A304] ; National Natural Science Foundation of China (NSFC) [30221004] ; Chinese Academy of Sciences [KSCX2-YW-R-38] ; Institute of Psychology, Chinese Academy of Sciences [O9CX115011] ; 863 grant
项目简介This work was sponsored by the National High Technology Research and Development Program of China (863 Program) (Grant No. 2006AA02A304, to ZSS) from the Ministry of Science and Technology of the People's Republic of China; the National Natural Science Foundation of China (NSFC) (Grant No. 30221004, to ZSS); the Innovation Project of Chinese Academy of Sciences (KSCX2-YW-R-38, to ZSS); and Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (O9CX115011, to KZ). Funding to pay the Open Access publication charges for this article was also provided by the 863 grant. We thank Dr Laurie Goodman for her helpful suggestions to help us refine the manuscript. We also thank all staffs at Institute of Psychology, Chinese Academy of Sciences, for their sincere supports. We thank the anonymous reviewers for kind comments.
WOS记录号WOS:000286425600001
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13275
专题中国科学院心理健康重点实验室
通讯作者Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China
3.Zhejiang Univ, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
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Yang, Liu,Zhang, Kunlin,Dai, Wei,et al. Systematic evaluation of genome-wide methylated DNA enrichment using a CpG island array[J]. BMC GENOMICS,2011,12.
APA Yang, Liu.,Zhang, Kunlin.,Dai, Wei.,He, Ximiao.,Zhao, Qian.,...&Wang, J .(2011).Systematic evaluation of genome-wide methylated DNA enrichment using a CpG island array.BMC GENOMICS,12.
MLA Yang, Liu,et al."Systematic evaluation of genome-wide methylated DNA enrichment using a CpG island array".BMC GENOMICS 12(2011).
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