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The effects of morphine on basal neuronal activities in the lateral and medial pain pathways
Su, Yuan-Lin1,2; Huang, Jin3; Wang, Ning1; Wang, Jin-Yan1; Luo, Fei1; Wang, JY (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.
2012-09-13
Source PublicationNEUROSCIENCE LETTERS
ISSN0304-3940
SubtypeArticle
Volume525Issue:2Pages:173-178
Contribution Rank1
AbstractNumerous studies indicate that morphine suppresses pain-evoked activities in both spinal and supraspinal regions. However, little is known about the effect of morphine on the basal brain activity in the absence of pain. The present study was designed to assess the effects of single-dose morphine on the spontaneous discharge of many simultaneously recorded single units, as well as their functional connections, in the lateral pain pathway, including the primary somatosensory cortex (SI) and ventral posterolateral thalamus (VPL), and medial pain pathway, including the anterior cingulate cortex (ACC) and medial dorsal thalamus (MD), in awake rats. Morphine (5 mg/kg) was administered intraperitoneally before the recording. Naloxone plus morphine and normal saline injections were performed respectively as controls. The results showed that morphine administration produced significant changes in the spontaneous neuronal activity in more than one third of the total recorded neurons, with primary activation in the lateral pathway while both inhibition and activation in the medial pathway. Naloxone pretreatment completely blocked the effects induced by morphine. In addition, the correlated activities between and within both pain pathways was exclusively suppressed after morphine injection. These results suggest that morphine may play different roles in modulating neural activity in normal vs. pain states. Taken together, this is the first study investigating the morphine modulation of spontaneous neuronal activity within parallel pain pathways. It can be helpful for revealing neuronal population coding for the morphine action in the absence of pain, and shed light on the supraspinal mechanisms for preemptive analgesia. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
KeywordMorphine Spontaneous activity The primary somatosensory cortex The anterior cingulate cortex Thalamus
Subject AreaPhysiological Psychology/biological Psychology
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Indexed BySCI
Language英语
Funding OrganizationChinese Academy of Sciences [KSCX2-EW-Q-18, YZ200944, KSCX2-YW-R-254, KSCX2-EW-J-8] ; NNSF [30770688, 30970959, 61033011, 31171067] ; NIH Fogarty International Center [R03 TW008038]
Project Intro.This work was funded by the Knowledge Innovation Project (KSCX2-EW-Q-18) from the Chinese Academy of Sciences to J.Y.W.: NNSF grants (30770688, 30970959, 61033011, and 31171067), the Knowledge Innovation Project (YZ200944, KSCX2-YW-R-254, and KSCX2-EW-J-8) of the Chinese Academy of Sciences, and a grant from NIH Fogarty International Center (R03 TW008038) to F.L.
WOS IDWOS:000309015600017
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13293
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, JY (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100871, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Su, Yuan-Lin,Huang, Jin,Wang, Ning,et al. The effects of morphine on basal neuronal activities in the lateral and medial pain pathways[J]. NEUROSCIENCE LETTERS,2012,525(2):173-178.
APA Su, Yuan-Lin,Huang, Jin,Wang, Ning,Wang, Jin-Yan,Luo, Fei,&Wang, JY .(2012).The effects of morphine on basal neuronal activities in the lateral and medial pain pathways.NEUROSCIENCE LETTERS,525(2),173-178.
MLA Su, Yuan-Lin,et al."The effects of morphine on basal neuronal activities in the lateral and medial pain pathways".NEUROSCIENCE LETTERS 525.2(2012):173-178.
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