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Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice
Yuan, Xiao-Ying2,3; Ma, Hui-Min2; Li, Rui-Zhi4; Wang, Rui-Yan2; Liu, Wei2,3; Guo, Jian-You1; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011-05-11
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
文章类型Article
卷号658期号:2-3页码:263-269
产权排序4
摘要Aloperine has been shown to inhibit 2,4-dinitrofluorobenzene (DNFB) induced allergic contact dermatitis in BALB/c mice. In the present study, we further investigated the effect of aloperine on DNFB-induced atopic dermatitis-like skin lesions in NC/Nga mice. NC/Nga mice elicited atopic dermatitis-like skin lesions after the topical application of DNFB. Aloperine treatment significantly inhibited dermatitis index and ear thickness in DNFB-treated NC/Nga mice in a dose-dependent manner. Eosinophils, mast cells infiltration into the ears and plasma level of immunoglobulin (Ig) E were also suppressed by aloperine treatment. Finally, cytokine (interleukin (IL)-1 beta, IL-4, IL-6, IL-10, IL-13, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma) productions in ear biopsies homogenates were significantly elevated after DNFB challenge. Topical application of aloperine increased the immunosuppressive cytokine IL-10 level, while it reduced other cytokines production in a dose-dependent manner. Taken together, these data suggest that aloperine may be one of the effective therapeutic agents for the treatment of atopic dermatitis. (C) 2011 Elsevier B.V. All rights reserved.
关键词Aloperine Atopic dermatitis Mast cells Eosinophil IgE Cytokine
学科领域Medical Psychology
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收录类别SCI
语种英语
项目资助者Air Force General Hospital ; Xinjiang Hope Pharmaceutical Company ; Institute of Psychology of Chinese Academy of Sciences [08CX043004] ; Key Laboratory of Mental Health of Chinese Academy of Sciences ; National Natural Science Foundation of China [30800301] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-J-8, KSCX2-EW-Q-18]
项目简介This work was supported by grants from the Air Force General Hospital and Xinjiang Hope Pharmaceutical Company, the Young Scientist project from the Institute of Psychology of Chinese Academy of Sciences (08CX043004), Project from Key Laboratory of Mental Health of Chinese Academy of Sciences, the National Natural Science Foundation of China (30800301) and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-J-8 and KSCX2-EW-Q-18).
WOS记录号WOS:000290010500031
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13318
专题中国科学院心理健康重点实验室
通讯作者Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Gen Hosp AF, Dept Dermatol, Beijing 1000142, Peoples R China
3.China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China
4.Zhejiang Chinese Med Univ, Hangzhou 100053, Zhejiang, Peoples R China
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Yuan, Xiao-Ying,Ma, Hui-Min,Li, Rui-Zhi,et al. Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,658(2-3):263-269.
APA Yuan, Xiao-Ying.,Ma, Hui-Min.,Li, Rui-Zhi.,Wang, Rui-Yan.,Liu, Wei.,...&Guo, JY .(2011).Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.EUROPEAN JOURNAL OF PHARMACOLOGY,658(2-3),263-269.
MLA Yuan, Xiao-Ying,et al."Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice".EUROPEAN JOURNAL OF PHARMACOLOGY 658.2-3(2011):263-269.
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