Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice

	Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice
	Yuan, Xiao-Ying 2,3; Ma, Hui-Min 2; Li, Rui-Zhi 4; Wang, Rui-Yan 2; Liu, Wei 2,3; Guo, Jian-You1 ; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
心理所单位排序	4
摘要	Aloperine has been shown to inhibit 2,4-dinitrofluorobenzene (DNFB) induced allergic contact dermatitis in BALB/c mice. In the present study, we further investigated the effect of aloperine on DNFB-induced atopic dermatitis-like skin lesions in NC/Nga mice. NC/Nga mice elicited atopic dermatitis-like skin lesions after the topical application of DNFB. Aloperine treatment significantly inhibited dermatitis index and ear thickness in DNFB-treated NC/Nga mice in a dose-dependent manner. Eosinophils, mast cells infiltration into the ears and plasma level of immunoglobulin (Ig) E were also suppressed by aloperine treatment. Finally, cytokine (interleukin (IL)-1 beta, IL-4, IL-6, IL-10, IL-13, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma) productions in ear biopsies homogenates were significantly elevated after DNFB challenge. Topical application of aloperine increased the immunosuppressive cytokine IL-10 level, while it reduced other cytokines production in a dose-dependent manner. Taken together, these data suggest that aloperine may be one of the effective therapeutic agents for the treatment of atopic dermatitis. (C) 2011 Elsevier B.V. All rights reserved.
关键词	Aloperine Atopic dermatitis Mast cells Eosinophil IgE Cytokine
学科领域	Medical Psychology
	2011-05-11
语种	英语
发表期刊	EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN	0014-2999
卷号	658 期号:2-3 页码:263-269
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This work was supported by grants from the Air Force General Hospital and Xinjiang Hope Pharmaceutical Company, the Young Scientist project from the Institute of Psychology of Chinese Academy of Sciences (08CX043004), Project from Key Laboratory of Mental Health of Chinese Academy of Sciences, the National Natural Science Foundation of China (30800301) and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-J-8 and KSCX2-EW-Q-18).
WOS记录号	WOS:000290010500031
资助机构	Air Force General Hospital ; Xinjiang Hope Pharmaceutical Company ; Institute of Psychology of Chinese Academy of Sciences [08CX043004] ; Key Laboratory of Mental Health of Chinese Academy of Sciences ; National Natural Science Foundation of China [30800301] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-J-8, KSCX2-EW-Q-18]
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13318
专题	中国科学院心理健康重点实验室
通讯作者	Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Gen Hosp AF, Dept Dermatol, Beijing 1000142, Peoples R China 3.China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China 4.Zhejiang Chinese Med Univ, Hangzhou 100053, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xiao-Ying,Ma, Hui-Min,Li, Rui-Zhi,et al. Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,658(2-3):263-269.
APA	Yuan, Xiao-Ying.,Ma, Hui-Min.,Li, Rui-Zhi.,Wang, Rui-Yan.,Liu, Wei.,...&Guo, JY .(2011).Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.EUROPEAN JOURNAL OF PHARMACOLOGY,658(2-3),263-269.
MLA	Yuan, Xiao-Ying,et al."Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice".EUROPEAN JOURNAL OF PHARMACOLOGY 658.2-3(2011):263-269.

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