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Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice
Yuan, Xiao-Ying2,3; Ma, Hui-Min2; Li, Rui-Zhi4; Wang, Rui-Yan2; Liu, Wei2,3; Guo, Jian-You1; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011-05-11
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
SubtypeArticle
Volume658Issue:2-3Pages:263-269
Contribution Rank4
AbstractAloperine has been shown to inhibit 2,4-dinitrofluorobenzene (DNFB) induced allergic contact dermatitis in BALB/c mice. In the present study, we further investigated the effect of aloperine on DNFB-induced atopic dermatitis-like skin lesions in NC/Nga mice. NC/Nga mice elicited atopic dermatitis-like skin lesions after the topical application of DNFB. Aloperine treatment significantly inhibited dermatitis index and ear thickness in DNFB-treated NC/Nga mice in a dose-dependent manner. Eosinophils, mast cells infiltration into the ears and plasma level of immunoglobulin (Ig) E were also suppressed by aloperine treatment. Finally, cytokine (interleukin (IL)-1 beta, IL-4, IL-6, IL-10, IL-13, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma) productions in ear biopsies homogenates were significantly elevated after DNFB challenge. Topical application of aloperine increased the immunosuppressive cytokine IL-10 level, while it reduced other cytokines production in a dose-dependent manner. Taken together, these data suggest that aloperine may be one of the effective therapeutic agents for the treatment of atopic dermatitis. (C) 2011 Elsevier B.V. All rights reserved.
KeywordAloperine Atopic dermatitis Mast cells Eosinophil IgE Cytokine
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationAir Force General Hospital ; Xinjiang Hope Pharmaceutical Company ; Institute of Psychology of Chinese Academy of Sciences [08CX043004] ; Key Laboratory of Mental Health of Chinese Academy of Sciences ; National Natural Science Foundation of China [30800301] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-J-8, KSCX2-EW-Q-18]
Project Intro.This work was supported by grants from the Air Force General Hospital and Xinjiang Hope Pharmaceutical Company, the Young Scientist project from the Institute of Psychology of Chinese Academy of Sciences (08CX043004), Project from Key Laboratory of Mental Health of Chinese Academy of Sciences, the National Natural Science Foundation of China (30800301) and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-J-8 and KSCX2-EW-Q-18).
WOS IDWOS:000290010500031
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13318
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Gen Hosp AF, Dept Dermatol, Beijing 1000142, Peoples R China
3.China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China
4.Zhejiang Chinese Med Univ, Hangzhou 100053, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Xiao-Ying,Ma, Hui-Min,Li, Rui-Zhi,et al. Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,658(2-3):263-269.
APA Yuan, Xiao-Ying.,Ma, Hui-Min.,Li, Rui-Zhi.,Wang, Rui-Yan.,Liu, Wei.,...&Guo, JY .(2011).Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.EUROPEAN JOURNAL OF PHARMACOLOGY,658(2-3),263-269.
MLA Yuan, Xiao-Ying,et al."Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice".EUROPEAN JOURNAL OF PHARMACOLOGY 658.2-3(2011):263-269.
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