中国科学院心理研究所机构知识库

The implications of increased understanding of the genetic contribution to schizophrenia for patients and their families remain unclear. We carried out a study of Chinese patients'(n = 118) and relatives' (n = 78) views of illness severity, attribution of cause, concern about developing illness, and effect of schizophrenia on family planning. A comparison sample of English-survey respondents was also obtained, using the same series of questions (n = 42 patients, n = 127 relatives). Fewer Chinese patients and family members rated schizophrenia as very severe (33%) than did the predominantly North American respondents (67%, p<0.0001). The pattern of attribution of cause differed between samples (p<0.0001), favoring environmental alone in the Chinese sample (52%), with a low frequency of genetics alone (9%). Although comparatively fewer Chinese respondents were very concerned about developing schizophrenia themselves or about the risk of illness in their families (21%), this high level of concern was more common in family members (28%). Finally, Chinese respondents were somewhat less likely to indicate that schizophrenia impacted on family planning decisions (31%) than were English-survey respondents (45%, p = 0.02). The descriptive findings contribute to understanding schizophrenia in China. The comparative findings must be regarded as preliminary, since differences in demographics could influence results. The present findings suggest that understanding patients' and families' attributions of cause of schizophrenia may be important for developing a shared model of illness in order to decrease stigmatization, and improve therapeutic alliances. (C) 2011 Elsevier B.V. All rights reserved.

The project was funded by: the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131 and KSCX2-EW-J-8), a grant from the National Basic Research Programme (973 Programme No. 2007CB512302/5), and an Outstanding National Young Investigator Award from the National Science Foundation China (81088001) to RCK Chan. Funding for the Canadian component was from the Canadian Institutes of Health Research (NET-54013), Michael Smith Foundation for Health Research, and the BC Mental Health and Addictions Services. None of the funding agencies had any influence over the data collection, analysis or preparation of the manuscript.