PSYCH OpenIR  > 中国科学院心理健康重点实验室
Two Sources of Genetic Liability to Depression: Interpreting the Relationship Between Stress Sensitivity and Depression Under a Multifactorial Polygenic Model
Li, Xinying2; McGue, Matt3; Gottesman, Irving I.1,3; Gottesman, II (reprint author), Univ Minnesota, Dept Psychiat, Sch Med, 2450 Riverside Ave, Minneapolis, MN 55454 USA.
2012-03-01
发表期刊BEHAVIOR GENETICS
ISSN0001-8244
文章类型Article
卷号42期号:2页码:268-277
产权排序1
摘要Psychopathology theories, clinical observations, and research all point to multiple sources of liability to depression. This article uses a longitudinal twin-study design to characterize the contribution of two genetically-influenced sources of depression risk: the first corresponding to stress sensitivity and the second representing risk that is independent of stress sensitivity. The sample consisted of 606 pairs of same-sex adolescent twins recruited from Beijing, China. Mean (SD) age at intake (Wave1) and follow-up (Wave2) was 13.2 (2.6) and 15.1 (2.6) years, respectively. A Reaction Level index was developed to reflect individual differences in stress sensitivity. Biometric models were fit to examine the genetic influence on the variance of and covariance between stress sensitivity and depressive symptoms. Results showed that both Reaction Level and depressive symptoms were moderately heritable. The genetic correlation between depressive symptoms and Reaction Level was estimated to be .884. Genetic contributions to Reaction Level accounted for 37.5% of the total variance of depressive symptoms. Another set of genetic factors, which did not contribute to Reaction Level, accounted for 10.5% of the total variance of depressive symptoms. We interpret our results within the context of a multifactorial polygenic model, whereby depression risk is due to the combined contribution of multiple genetic and environmental factors.
关键词China Twins Stress sensitivity Endophenotype Depressive symptoms Adolescence
学科领域Health Psychology,Emotional Psychology
收录类别SCI ; SSCI
语种英语
项目资助者Chinese Academy of Sciences [KSCX2-EW-J-8] ; National Natural Science Foundation of China [31170993]
项目简介This study was funded by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the National Natural Science Foundation of China (31170993). The first author was a postdoctoral guest worker in the Department of Psychology and the Institute of Child Development at the University of Minnesota while working on this project. We thank all the personnel involved in the sample recruitment and data collection. We dedicate this article to the memory of our late and beloved colleague Dr. Xiaojia Ge for his great contribution in founding the Beijing Adolescent Twin Project.
WOS记录号WOS:000302697100008
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13324
专题中国科学院心理健康重点实验室
通讯作者Gottesman, II (reprint author), Univ Minnesota, Dept Psychiat, Sch Med, 2450 Riverside Ave, Minneapolis, MN 55454 USA.
作者单位1.Univ Minnesota, Dept Psychiat, Sch Med, Minneapolis, MN 55454 USA
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA
推荐引用方式
GB/T 7714
Li, Xinying,McGue, Matt,Gottesman, Irving I.,et al. Two Sources of Genetic Liability to Depression: Interpreting the Relationship Between Stress Sensitivity and Depression Under a Multifactorial Polygenic Model[J]. BEHAVIOR GENETICS,2012,42(2):268-277.
APA Li, Xinying,McGue, Matt,Gottesman, Irving I.,&Gottesman, II .(2012).Two Sources of Genetic Liability to Depression: Interpreting the Relationship Between Stress Sensitivity and Depression Under a Multifactorial Polygenic Model.BEHAVIOR GENETICS,42(2),268-277.
MLA Li, Xinying,et al."Two Sources of Genetic Liability to Depression: Interpreting the Relationship Between Stress Sensitivity and Depression Under a Multifactorial Polygenic Model".BEHAVIOR GENETICS 42.2(2012):268-277.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000302697100008.p(274KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Xinying]的文章
[McGue, Matt]的文章
[Gottesman, Irving I.]的文章
百度学术
百度学术中相似的文章
[Li, Xinying]的文章
[McGue, Matt]的文章
[Gottesman, Irving I.]的文章
必应学术
必应学术中相似的文章
[Li, Xinying]的文章
[McGue, Matt]的文章
[Gottesman, Irving I.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。