PSYCH OpenIR  > 脑与认知科学国家重点实验室
Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?
Dazzan, Paola1; Chan, Raymond C. K.2; Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England.
2011-11-01
发表期刊CHINESE SCIENCE BULLETIN
ISSN1001-6538
文章类型Article
卷号56期号:32页码:3372-3375
产权排序2
摘要Approximately 60% of subjects with schizophrenia present minor neurological signs (neurological soft signs, NSS), which include abnormalities in sensory and motor performance indicative of a non-specific cerebral dysfunction. These are also present in healthy individuals and relatives of patients with psychosis, at significantly lower rates. The excess of NSS in psychosis may be a potential endophenotype for this disorder, and reflect the same neurodevelopmental brain dysfunction that also underlies the cognitive deficits consistently reported in psychosis. To establish whether neurological and cognitive dysfunction meet the essential criterion required for a refined endophenotype for psychosis, the association with the illness, we explored evidence that certain neurological and cognitive deficits co-occur in affected individuals. This evidence suggests that signs of motor dysfunctions may be specific to patients with psychosis, in whom they are associated with dysfunction in cognitive tasks requiring motor skills. Thus, they may form a promising candidate endophenotype for psychosis.
关键词schizophrenia neurological soft signs motor dysfunction basal ganglia cognition
学科领域Abnormal Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者BIAL Foundation ; NARSAD ; Project-Oriented Hundred Talents Programme [O7CX031003] ; Chinese Academy of Sciences [KSCX2-YW-R-131, KSCX2-EW-J-8] ; National Basic Research Program of China [2007CB512302] ; National Science Fund for Distinguished Young Scholars [81088001]
项目简介This work was supported by the BIAL Foundation, a NARSAD Young Investigator Award, and a NARSAD Independent Investigator Award to Dr. P. Dazzan. Also, The Project-Oriented Hundred Talents Programme (O7CX031003), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131, KSCX2-EW-J-8), a grant from the National Basic Research Program of China (2007CB512302), and the National Science Fund for Distinguished Young Scholars (81088001) to Prof. R. C. K Chan.
WOS记录号WOS:000296641800003
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13333
专题脑与认知科学国家重点实验室
通讯作者Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England.
作者单位1.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England
2.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Dazzan, Paola,Chan, Raymond C. K.,Dazzan, P . Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3372-3375.
APA Dazzan, Paola,Chan, Raymond C. K.,&Dazzan, P .(2011).Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?.CHINESE SCIENCE BULLETIN,56(32),3372-3375.
MLA Dazzan, Paola,et al."Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?".CHINESE SCIENCE BULLETIN 56.32(2011):3372-3375.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000296641800003.p(611KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Dazzan, Paola]的文章
[Chan, Raymond C. K.]的文章
[Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England.]的文章
百度学术
百度学术中相似的文章
[Dazzan, Paola]的文章
[Chan, Raymond C. K.]的文章
[Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England.]的文章
必应学术
必应学术中相似的文章
[Dazzan, Paola]的文章
[Chan, Raymond C. K.]的文章
[Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000296641800003.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。