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Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?
Dazzan, Paola1; Chan, Raymond C. K.2; Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England.
2011-11-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
SubtypeArticle
Volume56Issue:32Pages:3372-3375
Contribution Rank2
AbstractApproximately 60% of subjects with schizophrenia present minor neurological signs (neurological soft signs, NSS), which include abnormalities in sensory and motor performance indicative of a non-specific cerebral dysfunction. These are also present in healthy individuals and relatives of patients with psychosis, at significantly lower rates. The excess of NSS in psychosis may be a potential endophenotype for this disorder, and reflect the same neurodevelopmental brain dysfunction that also underlies the cognitive deficits consistently reported in psychosis. To establish whether neurological and cognitive dysfunction meet the essential criterion required for a refined endophenotype for psychosis, the association with the illness, we explored evidence that certain neurological and cognitive deficits co-occur in affected individuals. This evidence suggests that signs of motor dysfunctions may be specific to patients with psychosis, in whom they are associated with dysfunction in cognitive tasks requiring motor skills. Thus, they may form a promising candidate endophenotype for psychosis.
Keywordschizophrenia neurological soft signs motor dysfunction basal ganglia cognition
Subject AreaAbnormal Psychology
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Indexed BySCI
Language英语
Funding OrganizationBIAL Foundation ; NARSAD ; Project-Oriented Hundred Talents Programme [O7CX031003] ; Chinese Academy of Sciences [KSCX2-YW-R-131, KSCX2-EW-J-8] ; National Basic Research Program of China [2007CB512302] ; National Science Fund for Distinguished Young Scholars [81088001]
Project Intro.This work was supported by the BIAL Foundation, a NARSAD Young Investigator Award, and a NARSAD Independent Investigator Award to Dr. P. Dazzan. Also, The Project-Oriented Hundred Talents Programme (O7CX031003), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131, KSCX2-EW-J-8), a grant from the National Basic Research Program of China (2007CB512302), and the National Science Fund for Distinguished Young Scholars (81088001) to Prof. R. C. K Chan.
WOS IDWOS:000296641800003
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13333
Collection脑与认知科学国家重点实验室
Corresponding AuthorDazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England.
Affiliation1.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England
2.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
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GB/T 7714
Dazzan, Paola,Chan, Raymond C. K.,Dazzan, P . Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3372-3375.
APA Dazzan, Paola,Chan, Raymond C. K.,&Dazzan, P .(2011).Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?.CHINESE SCIENCE BULLETIN,56(32),3372-3375.
MLA Dazzan, Paola,et al."Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?".CHINESE SCIENCE BULLETIN 56.32(2011):3372-3375.
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