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Why Self-Induced Pain Feels Less Painful than Externally Generated Pain: Distinct Brain Activation Patterns in Self- and Externally Generated Pain
Wang, Yan1,2; Wang, Jin-Yan1; Luo, Fei1; Wang, Y (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011-08-26
Source PublicationPLOS ONE
ISSN1932-6203
SubtypeArticle
Volume6Issue:8
Contribution Rank1
AbstractVoluntary movement generally inhibits sensory systems. However, it is not clear how such movement influences pain. In the present study, subjects actively or passively experienced mechanical pain or pressure during functional MRI scanning. Pain and pressure were induced using two modified grip strengthener rings, each twined with four crystal bead strings, with polyhedral beads to induce pain, or spherical beads to induce pressure. Subjects held one ring in the left hand and were either asked to squeeze their left hand with their right hand (i.e., active pain or pressure), or to have their left hand squeezed by the experimenter (i.e., passive pain or pressure). Subjects rated the intensity and unpleasantness of the pain sensation lower in the active procedure than in the passive one. Correspondingly, pain-related brain areas were inhibited in the case of self-generated pain, including the primary somatosensory cortex (SI), anterior cingulate cortex (ACC), and the thalamus. These results suggest that active movement behaviorally inhibits concomitant mechanical pain, accompanied by an inhibition of pain response in pain-related brain areas such as the SI cortex. This might be part of the mechanisms underlying the kinesitherapy for pain treatment.
Subject AreaMedical Psychology,Physiological Psychology/biological Psychology
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Indexed BySCI ; SSCI
Language英语
Funding OrganizationNNSF [30700223, 30770688, 30970959] ; Beijing NNSF [5082008] ; 100 Talented Plan, two Knowledge Innovation Projects [KKCX1-YW-05, KSCX2-YW-R-254] ; Chinese Academy of Sciences [YZ200944] ; National Hi-Tech Research and Development Program of China [2008AA022604] ; NIH Fogarty International Center [R03TW008038]
Project Intro.This work was funded by a NNSF grant (30700223) to JYW, NNSF grants (30770688 and 30970959), a Beijing NNSF grant (5082008), the 100 Talented Plan, two Knowledge Innovation Projects (KKCX1-YW-05, KSCX2-YW-R-254), and a Scientific Apparatus Development Project of the Chinese Academy of Sciences (YZ200944), the National Hi-Tech Research and Development Program of China (Grant No. 2008AA022604), and a grant from NIH Fogarty International Center (R03TW008038) to FL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS IDWOS:000294298800013
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13335
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Y (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Yan,Wang, Jin-Yan,Luo, Fei,et al. Why Self-Induced Pain Feels Less Painful than Externally Generated Pain: Distinct Brain Activation Patterns in Self- and Externally Generated Pain[J]. PLOS ONE,2011,6(8).
APA Wang, Yan,Wang, Jin-Yan,Luo, Fei,&Wang, Y .(2011).Why Self-Induced Pain Feels Less Painful than Externally Generated Pain: Distinct Brain Activation Patterns in Self- and Externally Generated Pain.PLOS ONE,6(8).
MLA Wang, Yan,et al."Why Self-Induced Pain Feels Less Painful than Externally Generated Pain: Distinct Brain Activation Patterns in Self- and Externally Generated Pain".PLOS ONE 6.8(2011).
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