PSYCH OpenIR  > 中国科学院心理健康重点实验室
Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats
Dong, Xinwen1,2; Li, Yonghui2; Kirouac, Gilbert J.1,3
2015-06-16
发表期刊FRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
文章类型Article
卷号9期号:0页码:161
摘要The paraventricular nucleus of the thalamus (PVT) projects to the central nucleus of the amygdala and recent experimental evidence indicates a role for the PVT in conditioned fear. Furthermore, the PVT contains a high density of orexin receptors and fibers and acute injections of orexin antagonist into the PVT produce anxiolytic effects. The present study was done to determine if administration of a dual orexin receptor antagonist (DORA) in the region of the PVT interferes with the expression of conditioned fear in rats exposed to cued and contextual conditioning paradigms. Infusion of 0.5 mu l of the DORA N-biphenyl-2-yl-1-[(1-methyl-1H-benzimidazol-2yl) sulfanyl] acetyl-L-prolinamide at a concentration of 0.1, 1.0, and 10 nmol had no effect on the freezing produced by exposing rats to an auditory cue or the context associated with foot shock. In contrast, the 1.0 and 10 nmol doses were anxiolytic in the social interaction test. The results of the present study do not support a role for orexin receptors in the PVT in the expression of learned fear. The finding that the 1.0 and 10 nmol doses of DORA in the PVT region were anxiolytic in the social interaction test is consistent with other studies indicating a role for orexins in the PVT in anxiety-like behaviors.
关键词paraventricular nucleus fear orexin learning midline thalamus
收录类别SCI
语种英语
WOS记录号WOS:000356788000001
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13348
专题中国科学院心理健康重点实验室
作者单位1.Univ Manitoba, Fac Hlth Sci, Coll Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Manitoba, Fac Hlth Sci, Coll Med, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada
推荐引用方式
GB/T 7714
Dong, Xinwen,Li, Yonghui,Kirouac, Gilbert J.. Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2015,9(0):161.
APA Dong, Xinwen,Li, Yonghui,&Kirouac, Gilbert J..(2015).Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,9(0),161.
MLA Dong, Xinwen,et al."Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 9.0(2015):161.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000356788000001.(1527KB)期刊论文出版稿暂不开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Dong, Xinwen]的文章
[Li, Yonghui]的文章
[Kirouac, Gilbert J.]的文章
百度学术
百度学术中相似的文章
[Dong, Xinwen]的文章
[Li, Yonghui]的文章
[Kirouac, Gilbert J.]的文章
必应学术
必应学术中相似的文章
[Dong, Xinwen]的文章
[Li, Yonghui]的文章
[Kirouac, Gilbert J.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。