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Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats
Dong, Xinwen1,2; Li, Yonghui2; Kirouac, Gilbert J.1,3
2015-06-16
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
SubtypeArticle
Volume9Issue:0Pages:161
AbstractThe paraventricular nucleus of the thalamus (PVT) projects to the central nucleus of the amygdala and recent experimental evidence indicates a role for the PVT in conditioned fear. Furthermore, the PVT contains a high density of orexin receptors and fibers and acute injections of orexin antagonist into the PVT produce anxiolytic effects. The present study was done to determine if administration of a dual orexin receptor antagonist (DORA) in the region of the PVT interferes with the expression of conditioned fear in rats exposed to cued and contextual conditioning paradigms. Infusion of 0.5 mu l of the DORA N-biphenyl-2-yl-1-[(1-methyl-1H-benzimidazol-2yl) sulfanyl] acetyl-L-prolinamide at a concentration of 0.1, 1.0, and 10 nmol had no effect on the freezing produced by exposing rats to an auditory cue or the context associated with foot shock. In contrast, the 1.0 and 10 nmol doses were anxiolytic in the social interaction test. The results of the present study do not support a role for orexin receptors in the PVT in the expression of learned fear. The finding that the 1.0 and 10 nmol doses of DORA in the PVT region were anxiolytic in the social interaction test is consistent with other studies indicating a role for orexins in the PVT in anxiety-like behaviors.
Keywordparaventricular nucleus fear orexin learning midline thalamus
Indexed BySCI
Language英语
WOS IDWOS:000356788000001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13348
Collection中国科学院心理健康重点实验室
Affiliation1.Univ Manitoba, Fac Hlth Sci, Coll Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Manitoba, Fac Hlth Sci, Coll Med, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Dong, Xinwen,Li, Yonghui,Kirouac, Gilbert J.. Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2015,9(0):161.
APA Dong, Xinwen,Li, Yonghui,&Kirouac, Gilbert J..(2015).Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,9(0),161.
MLA Dong, Xinwen,et al."Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 9.0(2015):161.
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