Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats

	Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats
	Dong, Xinwen1,2 ; Li, Yonghui2 ; Kirouac, Gilbert J.1,3
摘要	The paraventricular nucleus of the thalamus (PVT) projects to the central nucleus of the amygdala and recent experimental evidence indicates a role for the PVT in conditioned fear. Furthermore, the PVT contains a high density of orexin receptors and fibers and acute injections of orexin antagonist into the PVT produce anxiolytic effects. The present study was done to determine if administration of a dual orexin receptor antagonist (DORA) in the region of the PVT interferes with the expression of conditioned fear in rats exposed to cued and contextual conditioning paradigms. Infusion of 0.5 mu l of the DORA N-biphenyl-2-yl-1-[(1-methyl-1H-benzimidazol-2yl) sulfanyl] acetyl-L-prolinamide at a concentration of 0.1, 1.0, and 10 nmol had no effect on the freezing produced by exposing rats to an auditory cue or the context associated with foot shock. In contrast, the 1.0 and 10 nmol doses were anxiolytic in the social interaction test. The results of the present study do not support a role for orexin receptors in the PVT in the expression of learned fear. The finding that the 1.0 and 10 nmol doses of DORA in the PVT region were anxiolytic in the social interaction test is consistent with other studies indicating a role for orexins in the PVT in anxiety-like behaviors.
关键词	paraventricular nucleus fear orexin learning midline thalamus
	2015-06-16
语种	英语
发表期刊	FRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN	1662-5153
卷号	9 期号:0 页码:161
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000356788000001
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13348
专题	中国科学院心理健康重点实验室
作者单位	1.Univ Manitoba, Fac Hlth Sci, Coll Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Manitoba, Fac Hlth Sci, Coll Med, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Dong, Xinwen,Li, Yonghui,Kirouac, Gilbert J.. Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2015,9(0):161.
APA	Dong, Xinwen,Li, Yonghui,&Kirouac, Gilbert J..(2015).Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,9(0),161.
MLA	Dong, Xinwen,et al."Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 9.0(2015):161.

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