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Examination of Local Functional Homogeneity in Autism
Jiang, Lili1,2; Hou, Xiao-Hui1,2,3; Yang, Ning1,2,3; Yang, Zhi1,2; Zuo, Xi-Nian1,2,4
2015
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133
SubtypeArticle
AbstractIncreasing neuroimaging evidence suggests that autism patients exhibit abnormal brain structure and function. We used the Autism Brain Imaging Data Exchange (ABIDE) sample to analyze locally focal (similar to 8 mm) functional connectivity of 223 autism patients and 285 normal controls from 15 international sites using a recently developed surface-based approach. We observed enhanced local connectivity in the middle frontal cortex, left precuneus, and right superior temporal sulcus, and reduced local connectivity in the right insular cortex. The local connectivity in the right middle frontal gyrus was positively correlated with the total score of the autism diagnostic observation schedule whereas the local connectivity within the right superior temporal sulcus was positively correlated with total subscores of both the communication and the stereotyped behaviors and restricted interests of the schedule. Finally, significant interactions between age and clinical diagnosis were detected in the left precuneus. These findings replicated previous observations that used a volume-based approach and suggested possible neuropathological impairments of local information processing in the frontal, temporal, parietal, and insular cortices. Novel site-variability analysis demonstrated high reproducibility of our findings across the 15 international sites. The age-disease interaction provides a potential target region for future studies to further elucidate the neurodevelopmental mechanisms of autism.
Indexed BySCI
Language英语
WOS IDWOS:000356680100001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13354
Collection中国科学院行为科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Lili,Hou, Xiao-Hui,Yang, Ning,et al. Examination of Local Functional Homogeneity in Autism[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Jiang, Lili,Hou, Xiao-Hui,Yang, Ning,Yang, Zhi,&Zuo, Xi-Nian.(2015).Examination of Local Functional Homogeneity in Autism.BIOMED RESEARCH INTERNATIONAL.
MLA Jiang, Lili,et al."Examination of Local Functional Homogeneity in Autism".BIOMED RESEARCH INTERNATIONAL (2015).
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