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Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments | |
Liang, Jing1,2,3,4; Xu, Wei1; Hsu, Yutien2,3; Yee, X. Ada2,3; Chen, Lu2,3; Suedhof, C. Thomas1 | |
第一作者 | Liang, Jing ; Xu, Wei |
通讯作者邮箱 | weixu@stanford.edu ; tcs1@stanford.edu |
心理所单位排序 | 1 |
摘要 | Abnormal activity in the medial prefrontal cortex (mPFC) is consistently observed in neuropsychiatric disorders, but the mechanisms involved remain unclear. Chronic aberrant excitation and/or inhibition of mPFC neurons were proposed to cause cognitive impairments. However, direct evidence for this hypothesis is lacking because it is technically challenging to control synaptic properties in a chronic and locally restricted, yet specific, manner. Here, we generated conditional knockout (cKO) mice of neuroligin-2 (Nlgn2), a postsynaptic cell-adhesion molecule of inhibitory synapses linked to neuropsychiatric disorders. cKO of Nlgn2 in adult mPFC rendered Nlgn2 protein undetectable after already 2-3 weeks, but induced major reductions in synaptic inhibition after only 6-7 weeks, and caused parallel impairments in anxiety, fear memory and social interaction behaviors. Moreover, cKO of Nlgn2 severely impaired behavioral stimulation of immediate-early gene expression in the mPFC, suggesting that chronic reduction in synaptic inhibition uncoupled the mPFC from experience-dependent inputs. Our results indicate that Nlgn2 is required for continuous maintenance of inhibitory synapses in the adult mPFC, and that chronic impairment of local inhibition disengages the mPFC from its cognitive functions by partially uncoupling the mPFC from experience-induced inputs. |
2015-07-01 | |
发表期刊 | MOLECULAR PSYCHIATRY |
ISSN | 1359-4184 |
卷号 | 20期号:7页码:850-859 |
收录类别 | SCI |
WOS记录号 | WOS:000356611800007 |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/13359 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Xu, Wei; Suedhof, C. Thomas |
作者单位 | 1.Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA 2.Department of Neurosurgery, Stanford University, Stanford, CA, USA 3.Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA 4.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China |
第一作者单位 | 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Liang, Jing,Xu, Wei,Hsu, Yutien,et al. Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments[J]. MOLECULAR PSYCHIATRY,2015,20(7):850-859. |
APA | Liang, Jing,Xu, Wei,Hsu, Yutien,Yee, X. Ada,Chen, Lu,&Suedhof, C. Thomas.(2015).Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments.MOLECULAR PSYCHIATRY,20(7),850-859. |
MLA | Liang, Jing,et al."Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments".MOLECULAR PSYCHIATRY 20.7(2015):850-859. |
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WOS_000356611800007.(1036KB) | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 |
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