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Sodium Salicylate Suppresses GABAergic Inhibitory Activity in Neurons of Rodent Dorsal Raphe Nucleus
Jin, Yan1; Luo, Bin2; Su, Yan-Yan3; Wang, Xin-Xing4; Chen, Liang4; Wang, Ming4; Wang, Wei-Wen5; Chen, Lin1,4
2015-05-11
Source PublicationPLOS ONE
ISSN1932-6203
SubtypeArticle
Volume10Issue:5Pages:1-21
AbstractSodium salicylate (NaSal), a tinnitus inducing agent, can activate serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN) and can increase serotonin (5-HT) level in the inferior colliculus and the auditory cortex in rodents. To explore the underlying neural mechanisms, we first examined effects of NaSal on neuronal intrinsic properties and the inhibitory synaptic transmissions in DRN slices of rats by using whole-cell patch-clamp technique. We found that NaSal hyperpolarized the resting membrane potential, decreased the input resistance, and suppressed spontaneous and current-evoked firing in GABAergic neurons, but not in 5-HTergic neurons. In addition, NaSal reduced GABAergic spontaneous and miniature inhibitory postsynaptic currents in 5-HTergic neurons. We next examined whether the observed depression of GABAergic activity would cause an increase in the excitability of 5-HTergic neurons using optogenetic technique in DRN slices of the transgenic mouse with channelrhodopsin-2 expressed in GABAergic neurons. When the GABAergic inhibition was enhanced by optical stimulation to GABAergic neurons in mouse DRN, NaSal significantly depolarized the resting membrane potential, increased the input resistance and increased current-evoked firing of 5-HTergic neurons. However, NaSal would fail to increase the excitability of 5-HTergic neurons when the GABAergic synaptic transmission was blocked by picrotoxin, a GABA receptor antagonist. Our results indicate that NaSal suppresses the GABAergic activities to raise the excitability of local 5-HTergic neural circuits in the DRN, which may contribute to the elevated 5-HT level by NaSal in the brain.
Indexed BySCI
Language英语
WOS IDWOS:000354542500162
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13364
Collection中国科学院心理健康重点实验室
Affiliation1.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Brain Funct & Dis, Hefei 230027, Peoples R China
2.Anhui Prov Hosp, Dept Otolaryngol Head & Neck Surg, Hefei 230001, Peoples R China
3.Anhui Med Univ, Dept Anat, Hefei 230032, Peoples R China
4.Univ Sci & Technol China, Auditory Res Lab, Hefei 230027, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Jin, Yan,Luo, Bin,Su, Yan-Yan,et al. Sodium Salicylate Suppresses GABAergic Inhibitory Activity in Neurons of Rodent Dorsal Raphe Nucleus[J]. PLOS ONE,2015,10(5):1-21.
APA Jin, Yan.,Luo, Bin.,Su, Yan-Yan.,Wang, Xin-Xing.,Chen, Liang.,...&Chen, Lin.(2015).Sodium Salicylate Suppresses GABAergic Inhibitory Activity in Neurons of Rodent Dorsal Raphe Nucleus.PLOS ONE,10(5),1-21.
MLA Jin, Yan,et al."Sodium Salicylate Suppresses GABAergic Inhibitory Activity in Neurons of Rodent Dorsal Raphe Nucleus".PLOS ONE 10.5(2015):1-21.
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