PSYCH OpenIR  > 健康与遗传心理学研究室
Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer
Wang, Guan1; Li, Xianfeng2; Tian, Weiping3; Wang, Yan4; Wu, Dandan1; Sun, Zhongsheng5; Zhao, Enfeng6
2015-07-01
Source PublicationGENES CHROMOSOMES & CANCER
ISSN1045-2257
SubtypeArticle
Volume54Issue:7Pages:453-462
AbstractAs a transforming growth factor- (TGF-)-inducible gene, the expression of Kruppel-like transcription factor 11 (KLF11) is altered in several types of cancer. In the current study, through using human 9K CpG island array, KLF11 was identified as one of hypermethylated genes in RAS-transformed ovarian T29H cells. Methylation of the KLF11 promoter was also observed in ovarian cancer tissue samples accompanied by significantly reduced KLF11 gene expression. Interestingly, the expression of SMAD2, SMAD3, and SMAD7 genes was reduced in the tumour, whilst no change was found in TGF- expression. Our data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis. (c) 2015 Wiley Periodicals, Inc.
Indexed BySCI
Language英语
WOS IDWOS:000354745000006
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13366
Collection健康与遗传心理学研究室
Affiliation1.Tianjin Cent Hosp Obstet & Gynecol, Dept Obstet & Gynecol, Tianjin 300100, Peoples R China
2.Cent S Univ, State Key Lab Med Genet, Changsha 410078, Hunan, Peoples R China
3.Tianjin Med Univ, Tianjin Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Dept Obstet & Gynecol, Beijing 100853, Peoples R China
Recommended Citation
GB/T 7714
Wang, Guan,Li, Xianfeng,Tian, Weiping,et al. Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer[J]. GENES CHROMOSOMES & CANCER,2015,54(7):453-462.
APA Wang, Guan.,Li, Xianfeng.,Tian, Weiping.,Wang, Yan.,Wu, Dandan.,...&Zhao, Enfeng.(2015).Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer.GENES CHROMOSOMES & CANCER,54(7),453-462.
MLA Wang, Guan,et al."Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer".GENES CHROMOSOMES & CANCER 54.7(2015):453-462.
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