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Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer
Wang, Guan1; Li, Xianfeng2; Tian, Weiping3; Wang, Yan4; Wu, Dandan1; Sun, Zhongsheng5; Zhao, Enfeng6
2015-07-01
发表期刊GENES CHROMOSOMES & CANCER
ISSN1045-2257
文章类型Article
卷号54期号:7页码:453-462
摘要As a transforming growth factor- (TGF-)-inducible gene, the expression of Kruppel-like transcription factor 11 (KLF11) is altered in several types of cancer. In the current study, through using human 9K CpG island array, KLF11 was identified as one of hypermethylated genes in RAS-transformed ovarian T29H cells. Methylation of the KLF11 promoter was also observed in ovarian cancer tissue samples accompanied by significantly reduced KLF11 gene expression. Interestingly, the expression of SMAD2, SMAD3, and SMAD7 genes was reduced in the tumour, whilst no change was found in TGF- expression. Our data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis. (c) 2015 Wiley Periodicals, Inc.
收录类别SCI
语种英语
WOS记录号WOS:000354745000006
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13366
专题健康与遗传心理学研究室
作者单位1.Tianjin Cent Hosp Obstet & Gynecol, Dept Obstet & Gynecol, Tianjin 300100, Peoples R China
2.Cent S Univ, State Key Lab Med Genet, Changsha 410078, Hunan, Peoples R China
3.Tianjin Med Univ, Tianjin Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Dept Obstet & Gynecol, Beijing 100853, Peoples R China
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Wang, Guan,Li, Xianfeng,Tian, Weiping,et al. Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer[J]. GENES CHROMOSOMES & CANCER,2015,54(7):453-462.
APA Wang, Guan.,Li, Xianfeng.,Tian, Weiping.,Wang, Yan.,Wu, Dandan.,...&Zhao, Enfeng.(2015).Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer.GENES CHROMOSOMES & CANCER,54(7),453-462.
MLA Wang, Guan,et al."Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer".GENES CHROMOSOMES & CANCER 54.7(2015):453-462.
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