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Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague-Dawley rats
Xing, Xiaoli1,2; Wang, Hongbo2; Zhang, Lili1; Bai, Yunjing1; Liang, Jing1; Liu, Zhengkui1; Zheng, Xigeng1
2015-06-01
Source PublicationPHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
SubtypeArticle
Volume133Issue:0Pages:43-50
AbstractThe return of fear is an important issue in anxiety disorder research. Each time a fear memory is reactivated, it may further strengthen overactivation of the fear circuit, which may contribute to long-term maintenance of the fear memory. Recent evidence indicates that glucocorticoids may help attenuate pathological fear, but its role in the return of fear is unclear. In the present study, systemic corticosterone (CORT; 25 mg/kg) administration 1 h after fear conditioning did not impair the consolidation process but significantly suppressed the return of fear evoked by a subthreshold conditioning (SC) procedure and elevated platform (EP) stress. Compared with the SC-induced return of fear, acute stress-induced return was state-dependent. In addition, post-training CORT treatment increased the adrenocorticotropic response after EP stress, which indicates that the drug-induced suppression of the return of fear may possibly derive from its regulation effect of the hypothalamic-pituitary-adrenal axis reactivity to stress. These results suggest that post-training CORT administration may help inhibit the return of fear evoked by EP or SC stress. The possible mechanisms involved in the high-dose CORT-induced suppression of the SC- and EP-induced return of fear are discussed. (C) 2015 Elsevier Inc. All rights reserved.
KeywordCorticosterone Extinction Fear conditioning Fear return Subthreshold conditioning procedure
Indexed BySCI
Language英语
WOS IDWOS:000355883000007
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13371
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Henan Univ, Sch Educ Sci, Kaifeng 475001, Henan Province, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Xing, Xiaoli,Wang, Hongbo,Zhang, Lili,et al. Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague-Dawley rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2015,133(0):43-50.
APA Xing, Xiaoli.,Wang, Hongbo.,Zhang, Lili.,Bai, Yunjing.,Liang, Jing.,...&Zheng, Xigeng.(2015).Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague-Dawley rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,133(0),43-50.
MLA Xing, Xiaoli,et al."Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague-Dawley rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 133.0(2015):43-50.
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