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题名:
Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference
作者: Tao, Haojuan1; Wong, Gloria H. Y.2,3; Zhang, Huiran1; Yuan Zhou(周媛)4; Xue, Zhimin1; Shan, Baoci5; Chen, Eric Y. H.2; Liu, Zhening1
文章类型: Article
关键词: Grey matter morphology ; Voxel-based morphometry ; Caudate ; Delusions
刊名: PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN号: 0925-4927
出版日期: 2015-07-30
卷号: 233, 期号:1, 页码:57-63
收录类别: SCI
英文摘要: Delusions of reference (DOR) are theoretically linked with aberrant salience and associative learning. Previous studies have shown that the caudate nucleus plays a critical role in the cognitive circuits of coding prediction errors and associative learning. The current study aimed at testing the hypothesis that abnormalities in the caudate nucleus may be involved in the neuroanatomical substrate of DOR. Structural magnetic resonance imaging of the brain was performed in 44 first-episode psychosis patients (with diagnoses of schizophrenia or schizophreniform disorder) and 25 healthy controls. Patients were divided into three groups according to symptoms: patients with DOR as prominent positive symptom; patients with prominent positive symptoms other than DOR; and patients with minimal positive symptoms. All groups were age-, gender-, and education-matched, and patient groups were matched for diagnosis, duration of illness, and antipsychotic treatment. Voxel-based morphometric analysis was performed to identify group differences in grey matter density. Relationships were explored between grey matter density and DOR. Patients with DOR were found to have reduced grey matter density in the caudate compared with patients without DOR and healthy controls. Grey matter density values of the left and right caudate head were negatively correlated with DOR severity. Decreased grey matter density in the caudate nucleus may underlie DOR in early psychosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved
语种: 英语
WOS记录号: WOS:000355671600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/13379
Appears in Collections:中国科学院行为科学重点实验室_期刊论文

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作者单位: 1.Cent S Univ, Xiangya Hosp 2, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Natl Technol Inst Psychiat, Changsha 410011, Hunan, Peoples R China
2.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Sau Po Ctr Ageing, Hong Kong, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal Tech, Beijing, Peoples R China

Recommended Citation:
Tao, Haojuan,Wong, Gloria H. Y.,Zhang, Huiran,et al. Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,233(1):57-63.
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