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Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference
Tao, Haojuan1; Wong, Gloria H. Y.2,3; Zhang, Huiran1; Zhou, Yuan4; Xue, Zhimin1; Shan, Baoci5; Chen, Eric Y. H.2; Liu, Zhening1
2015-07-30
发表期刊PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
文章类型Article
卷号233期号:1页码:57-63
摘要Delusions of reference (DOR) are theoretically linked with aberrant salience and associative learning. Previous studies have shown that the caudate nucleus plays a critical role in the cognitive circuits of coding prediction errors and associative learning. The current study aimed at testing the hypothesis that abnormalities in the caudate nucleus may be involved in the neuroanatomical substrate of DOR. Structural magnetic resonance imaging of the brain was performed in 44 first-episode psychosis patients (with diagnoses of schizophrenia or schizophreniform disorder) and 25 healthy controls. Patients were divided into three groups according to symptoms: patients with DOR as prominent positive symptom; patients with prominent positive symptoms other than DOR; and patients with minimal positive symptoms. All groups were age-, gender-, and education-matched, and patient groups were matched for diagnosis, duration of illness, and antipsychotic treatment. Voxel-based morphometric analysis was performed to identify group differences in grey matter density. Relationships were explored between grey matter density and DOR. Patients with DOR were found to have reduced grey matter density in the caudate compared with patients without DOR and healthy controls. Grey matter density values of the left and right caudate head were negatively correlated with DOR severity. Decreased grey matter density in the caudate nucleus may underlie DOR in early psychosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved
关键词Grey matter morphology Voxel-based morphometry Caudate Delusions
收录类别SCI
语种英语
WOS记录号WOS:000355671600008
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13379
专题中国科学院行为科学重点实验室
作者单位1.Cent S Univ, Xiangya Hosp 2, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Natl Technol Inst Psychiat, Changsha 410011, Hunan, Peoples R China
2.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Sau Po Ctr Ageing, Hong Kong, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal Tech, Beijing, Peoples R China
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Tao, Haojuan,Wong, Gloria H. Y.,Zhang, Huiran,et al. Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,233(1):57-63.
APA Tao, Haojuan.,Wong, Gloria H. Y..,Zhang, Huiran.,Zhou, Yuan.,Xue, Zhimin.,...&Liu, Zhening.(2015).Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference.PSYCHIATRY RESEARCH-NEUROIMAGING,233(1),57-63.
MLA Tao, Haojuan,et al."Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference".PSYCHIATRY RESEARCH-NEUROIMAGING 233.1(2015):57-63.
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