Course of neurological soft signs in first-episode schizophrenia: Relationship with negative symptoms and cognitive performances

	Course of neurological soft signs in first-episode schizophrenia: Relationship with negative symptoms and cognitive performances
	Chan, Raymond C. K.1 ; Geng, Fu-lei 1,2; Lui, Simon S. Y.1,2,3; Wang, Ya1 ; Ho, Karen K. Y.3; Hung, Karen S. Y.3; Gur, Raquel E.4,5; Gur, Ruben C.4,5; Cheung, Eric F. C.3
摘要	This prospective study examined the course of neurological soft signs (NSS) in patients with first-episode schizophrenia and its relationship with negative symptoms and cognitive functions. One hundred and forty-five patients with first-episode schizophrenia were recruited, 29 were classified as having prominent negative symptoms. NSS and neuropsychological measures were administered to all patients and 62 healthy controls at baseline. Patients were then followed-up prospectively at six-month intervals for up to a year. Patients with prominent negative symptoms exhibited significantly more motor coordination signs and total NSS than patients without prominent negative symptoms. Patients with prominent negative symptoms performed worse than patients without negative symptoms in working memory functions but not other fronto-parietal or fronto-temporal functions. Linear growth model for binary data showed that the prominent negative symptoms were stable over time. Despite general improvement in NSS and neuropsychological functions, the prominent negative symptoms group still exhibited poorer motor coordination and higher levels of NSS, as well as poorer working memory than patients without prominent negative symptoms. Two distinct subtypes of first-episode patients could be distinguished by NSS and prominent negative symptoms.
	2015-06-08
语种	英语
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5 期号:0 页码:11053
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000356069100001
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13380
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 4.Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA 5.Philadelphia Vet Adm Med Ctr, Philadelphia, PA USA
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Chan, Raymond C. K.,Geng, Fu-lei,Lui, Simon S. Y.,et al. Course of neurological soft signs in first-episode schizophrenia: Relationship with negative symptoms and cognitive performances[J]. SCIENTIFIC REPORTS,2015,5(0):11053.
APA	Chan, Raymond C. K..,Geng, Fu-lei.,Lui, Simon S. Y..,Wang, Ya.,Ho, Karen K. Y..,...&Cheung, Eric F. C..(2015).Course of neurological soft signs in first-episode schizophrenia: Relationship with negative symptoms and cognitive performances.SCIENTIFIC REPORTS,5(0),11053.
MLA	Chan, Raymond C. K.,et al."Course of neurological soft signs in first-episode schizophrenia: Relationship with negative symptoms and cognitive performances".SCIENTIFIC REPORTS 5.0(2015):11053.

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