PSYCH OpenIR  > 中国科学院心理健康重点实验室
Sex-Specific Diurnal Immobility Induced by Forced Swim Test in Wild Type and Clock Gene Deficient Mice
Li, Ningyue; Xu, Yanhua; Chen, Xiaojuan; Duan, Qing; Zhao, Mei
2015-04-01
发表期刊INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
文章类型Article
卷号16期号:4页码:6831-6841
摘要Objective: The link between alterations in circadian rhythms and depression are well established, but the underlying mechanisms are far less elucidated. We investigated the circadian characteristics of immobility behavior in wild type (WT) mice and mice with mutations in core Clock genes. Methods: All mice were tested with forced swim test (FST) at 4 h intervals. Results: These experiments revealed significant diurnal rhythms associated with immobility behavior in both male and female WT mice with sex-different circadian properties. In addition, male mice showed significantly less immobility during the night phase in comparison to female mice. Female Per1(Brdm1) mice also showed significant rhythmicity. However, the timing of rhythmicity was very different from that observed in female wild type mice. Male Per1(Brdm1) mice showed a pattern of rhythmicity similar to that of wild type mice. Furthermore, female Per1(Brdm1) mice showed higher duration of immobility in comparison to male Per1(Brdm1) mice in both daytime and early night phases. Neither Per2(Brdm1) nor Clock(19) mice showed significant rhythmicity, but both female Per2(Brdm1) and Clock(19) mice had lower levels of immobility, compared to males. Conclusions: This study highlights the differences in the circadian characteristics of immobility induced by FST in WT, Clock(19), Per1, and Per2 deficient mice.
关键词circadian clock gene mutant sex-difference immobility forced swim
收录类别SCI
语种英语
WOS记录号WOS:000354040400012
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13398
专题中国科学院心理健康重点实验室
作者单位Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Li, Ningyue,Xu, Yanhua,Chen, Xiaojuan,et al. Sex-Specific Diurnal Immobility Induced by Forced Swim Test in Wild Type and Clock Gene Deficient Mice[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015,16(4):6831-6841.
APA Li, Ningyue,Xu, Yanhua,Chen, Xiaojuan,Duan, Qing,&Zhao, Mei.(2015).Sex-Specific Diurnal Immobility Induced by Forced Swim Test in Wild Type and Clock Gene Deficient Mice.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(4),6831-6841.
MLA Li, Ningyue,et al."Sex-Specific Diurnal Immobility Induced by Forced Swim Test in Wild Type and Clock Gene Deficient Mice".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16.4(2015):6831-6841.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000354040400012.(738KB)期刊论文出版稿暂不开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Ningyue]的文章
[Xu, Yanhua]的文章
[Chen, Xiaojuan]的文章
百度学术
百度学术中相似的文章
[Li, Ningyue]的文章
[Xu, Yanhua]的文章
[Chen, Xiaojuan]的文章
必应学术
必应学术中相似的文章
[Li, Ningyue]的文章
[Xu, Yanhua]的文章
[Chen, Xiaojuan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。