The novel long non-coding RNA CRG regulates Drosophila locomotor behavior

	The novel long non-coding RNA CRG regulates Drosophila locomotor behavior
	Li, Meixia 1; Wen, Shengyun 1,2; Guo, Xiangqian 3; Bai, Baoyan 3; Gong, Zhefeng 1; Liu, Xiaojun 4,5; Wang, Yijin 1,2; Zhou, Yanqiong 1,2; Chen, Xiaowei 2,3; Liu, Li1,6 ; Chen, Runsheng 3
摘要	Long non-coding RNAs (lncRNAs) that have no protein-coding capacity make up a large proportion of the transcriptome of various species. Many lncRNAs are expressed within the animal central nervous system in spatial- and temporal-specific patterns, indicating that lncRNAs play important roles in cellular processes, neural development, and even in cognitive and behavioral processes. However, relatively little is known about their in vivo functions and underlying molecular mechanisms in the nervous system. Here, we report a neural-specific Drosophila lncRNA, CASK regulatory gene (CRG), which participates in locomotor activity and climbing ability by positively regulating its neighboring gene CASK (Ca2+/calmodulin-dependent protein kinase). CRG deficiency led to reduced locomotor activity and a defective climbing ability-phenotypes that are often seen in CASK mutant. CRG mutant also showed reduced CASK expression level while CASK over-expression could rescue the CRG mutant phenotypes in reciprocal. At the molecular level, CRG was required for the recruitment of RNA polymerase II to the CASK promoter regions, which in turn enhanced CASK expression. Our work has revealed new functional roles of lncRNAs and has provided insights to explore the pathogenesis of neurological diseases associated with movement disorders.
	2012-12-01
语种	英语
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	40 期号:22 页码:11714-11727
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000313414800053
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13404
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Key Lab Noncoding RNA, Beijing 100101, Peoples R China 4.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China 5.Peking Union Med Coll, Beijing 100005, Peoples R China 6.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
第一作者单位	脑与认知科学国家重点实验室
推荐引用方式 GB/T 7714	Li, Meixia,Wen, Shengyun,Guo, Xiangqian,et al. The novel long non-coding RNA CRG regulates Drosophila locomotor behavior[J]. NUCLEIC ACIDS RESEARCH,2012,40(22):11714-11727.
APA	Li, Meixia.,Wen, Shengyun.,Guo, Xiangqian.,Bai, Baoyan.,Gong, Zhefeng.,...&Chen, Runsheng.(2012).The novel long non-coding RNA CRG regulates Drosophila locomotor behavior.NUCLEIC ACIDS RESEARCH,40(22),11714-11727.
MLA	Li, Meixia,et al."The novel long non-coding RNA CRG regulates Drosophila locomotor behavior".NUCLEIC ACIDS RESEARCH 40.22(2012):11714-11727.

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