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The novel long non-coding RNA CRG regulates Drosophila locomotor behavior
Li, Meixia1; Wen, Shengyun1,2; Guo, Xiangqian3; Bai, Baoyan3; Gong, Zhefeng1; Liu, Xiaojun4,5; Wang, Yijin1,2; Zhou, Yanqiong1,2; Chen, Xiaowei2,3; Liu, Li1,6; Chen, Runsheng3
2012-12-01
Source PublicationNUCLEIC ACIDS RESEARCH
ISSN0305-1048
SubtypeArticle
Volume40Issue:22Pages:11714-11727
AbstractLong non-coding RNAs (lncRNAs) that have no protein-coding capacity make up a large proportion of the transcriptome of various species. Many lncRNAs are expressed within the animal central nervous system in spatial- and temporal-specific patterns, indicating that lncRNAs play important roles in cellular processes, neural development, and even in cognitive and behavioral processes. However, relatively little is known about their in vivo functions and underlying molecular mechanisms in the nervous system. Here, we report a neural-specific Drosophila lncRNA, CASK regulatory gene (CRG), which participates in locomotor activity and climbing ability by positively regulating its neighboring gene CASK (Ca2+/calmodulin-dependent protein kinase). CRG deficiency led to reduced locomotor activity and a defective climbing ability-phenotypes that are often seen in CASK mutant. CRG mutant also showed reduced CASK expression level while CASK over-expression could rescue the CRG mutant phenotypes in reciprocal. At the molecular level, CRG was required for the recruitment of RNA polymerase II to the CASK promoter regions, which in turn enhanced CASK expression. Our work has revealed new functional roles of lncRNAs and has provided insights to explore the pathogenesis of neurological diseases associated with movement disorders.
Indexed BySCI
Language英语
WOS IDWOS:000313414800053
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13404
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Key Lab Noncoding RNA, Beijing 100101, Peoples R China
4.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
5.Peking Union Med Coll, Beijing 100005, Peoples R China
6.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Li, Meixia,Wen, Shengyun,Guo, Xiangqian,et al. The novel long non-coding RNA CRG regulates Drosophila locomotor behavior[J]. NUCLEIC ACIDS RESEARCH,2012,40(22):11714-11727.
APA Li, Meixia.,Wen, Shengyun.,Guo, Xiangqian.,Bai, Baoyan.,Gong, Zhefeng.,...&Chen, Runsheng.(2012).The novel long non-coding RNA CRG regulates Drosophila locomotor behavior.NUCLEIC ACIDS RESEARCH,40(22),11714-11727.
MLA Li, Meixia,et al."The novel long non-coding RNA CRG regulates Drosophila locomotor behavior".NUCLEIC ACIDS RESEARCH 40.22(2012):11714-11727.
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