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Brain Network Informed Subject Community Detection In Early-Onset Schizophrenia
Yang, Zhi1,2,6; Xu, Yong3; Xu, Ting1,6; Hoy, Colin W.2; Handwerker, Daniel A.2; Chen, Gang4; Northoff, Georg5; Zuo, Xi-Nian1,6; Bandettini, Peter A.2
2014-07-03
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
文章类型Article
卷号4期号:0页码:5549
摘要Early-onset schizophrenia (EOS) offers a unique opportunity to study pathophysiological mechanisms and development of schizophrenia. Using 26 drug-naive, first-episode EOS patients and 25 age- and gender-matched control subjects, we examined intrinsic connectivity network (ICN) deficits underlying EOS. Due to the emerging inconsistency between behavior-based psychiatric disease classification system and the underlying brain dysfunctions, we applied a fully data-driven approach to investigate whether the subjects can be grouped into highly homogeneous communities according to the characteristics of their ICNs. The resultant subject communities and the representative characteristics of ICNs were then associated with the clinical diagnosis and multivariate symptom patterns. A default mode ICN was statistically absent in EOS patients. Another frontotemporal ICN further distinguished EOS patients with predominantly negative symptoms. Connectivity patterns of this second network for the EOS patients with predominantly positive symptom were highly similar to typically developing controls. Our post-hoc functional connectivity modeling confirmed that connectivity strength in this frontotemporal circuit was significantly modulated by relative severity of positive and negative syndromes in EOS. This study presents a novel subtype discovery approach based on brain networks and proposes complex links between brain networks and symptom patterns in EOS.
收录类别SCI
语种英语
WOS记录号WOS:000338421800001
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/13437
专题中国科学院行为科学重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci & Magnet Resonance, Imaging Res Ctr, Beijing 100101, Peoples R China
2.NIMH, Sect Funct Imaging Methods, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA
3.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan 030001, Peoples R China
4.NIMH, Sci & Stat Comp Core, NIH, Bethesda, MD 20892 USA
5.Univ Ottawa, Mental Hlth Res Inst, Ottawa, ON K1Z 7K4, Canada
6.Chinese Acad Sci, Lab Funct Connectome & Dev, Inst Psychol, Beijing 100101, Peoples R China
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Yang, Zhi,Xu, Yong,Xu, Ting,et al. Brain Network Informed Subject Community Detection In Early-Onset Schizophrenia[J]. SCIENTIFIC REPORTS,2014,4(0):5549.
APA Yang, Zhi.,Xu, Yong.,Xu, Ting.,Hoy, Colin W..,Handwerker, Daniel A..,...&Bandettini, Peter A..(2014).Brain Network Informed Subject Community Detection In Early-Onset Schizophrenia.SCIENTIFIC REPORTS,4(0),5549.
MLA Yang, Zhi,et al."Brain Network Informed Subject Community Detection In Early-Onset Schizophrenia".SCIENTIFIC REPORTS 4.0(2014):5549.
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