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Identification of neurons responsible for feeding behavior in the Drosophila brain
Sun Fei1,2; Wang YiJin1; Zhou YanQiong1,3; Van Swinderen, Bruno3; Gong ZheFeng1,4; Liu Li1,5
AbstractDrosophila melanogaster feeds mainly on rotten fruits, which contain many kinds of sugar. Thus, the sense of sweet taste has evolved to serve as a dominant regulator and driver of feeding behavior. Although several sugar receptors have been described, it remains poorly understood how the sensory input is transformed into an appetitive behavior. Here, we used a neural silencing approach to screen brain circuits, and identified neurons labeled by three Ga14 lines that modulate Drosophila feeding behavior. These three Ga14 lines labeled neurons mainly in the suboesophageal ganglia (SOG), which is considered to be the fly's primary taste center. When we blocked the activity of these neurons, flies decreased their sugar consumption significantly. In contrast, activation of these neurons resulted in enhanced feeding behavior and increased food consumption not only towards sugar, but to an array of food sources. Moreover, upon neuronal activation, the flies demonstrated feeding behavior even in the absence of food, which suggests that neuronal activation can replace food as a stimulus for feeding behavior. These findings indicate that these Ga14-labeled neurons, which function downstream of sensory neurons and regulate feeding behavior towards different food sources is necessary in Drosophila feeding control.
Keywordfeeding behavior sugar-sensing neurons SOG CAFE assay proboscis extension response (PER)
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WOS IDWOS:000334559600006
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
4.Zhejiang Univ, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
5.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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GB/T 7714
Sun Fei,Wang YiJin,Zhou YanQiong,et al. Identification of neurons responsible for feeding behavior in the Drosophila brain[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(4):391-402.
APA Sun Fei,Wang YiJin,Zhou YanQiong,Van Swinderen, Bruno,Gong ZheFeng,&Liu Li.(2014).Identification of neurons responsible for feeding behavior in the Drosophila brain.SCIENCE CHINA-LIFE SCIENCES,57(4),391-402.
MLA Sun Fei,et al."Identification of neurons responsible for feeding behavior in the Drosophila brain".SCIENCE CHINA-LIFE SCIENCES 57.4(2014):391-402.
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