Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats

	Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats
	Wu, Yan 1,2; Li, Yonghui1 ; Yang, Xiaoyan1 ; Sui, Nan1
摘要	Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be disrupted by pharmacological treatment. The basolateral amygdala (BLA) has been shown to mediate the reconsolidation of drug-related appetitive memory, but its role in withdrawal-related aversive memory remains elusive. The present study used conditioned place preference (CPP) and conditioned place aversion (CPA) paradigms to investigate the role of BLA and its noradrenergic receptors in reconsolidation of morphine-associated emotional memory in rats. We found that inhibition of protein synthesis in BLA disrupted the reconsolidation of morphine CPP (m-CPP) and CPA related to morphine withdrawal (m-CPA). A high dose of the -noradrenergic receptor antagonist propranolol (3 mu g) in BLA-impaired reconsolidation of m-CPA but not m-CPP, whereas a low dose (0.3 mu g) was ineffective. In contrast, neither low nor high doses of the -noradrenergic receptor antagonist phentolamine (1 or 10 mu g) blocked the reconsolidation of m-CPP and m-CPA. In addition, infusion of propranolol (3 mu g) into nucleus accumbens after retrieval of either m-CPP or m-CPA did not affect its reconsolidation. The findings indicate that appetitive and aversive addictive memories share common neural substrates in BLA, but the specific neurotransmitter mechanism on reconsolidation of morphine-associated negative and positive memories can be dissociable.
关键词	Appetitive and aversive memory basolateral amygdala morphine noradrenergic receptors place conditioning reconsolidation
	2014
语种	英语
发表期刊	ADDICTION BIOLOGY
ISSN	1369-1600
卷号	19 期号:1 页码:5-15
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000328610300002
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13441
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Wu, Yan,Li, Yonghui,Yang, Xiaoyan,et al. Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats[J]. ADDICTION BIOLOGY,2014,19(1):5-15.
APA	Wu, Yan,Li, Yonghui,Yang, Xiaoyan,&Sui, Nan.(2014).Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats.ADDICTION BIOLOGY,19(1),5-15.
MLA	Wu, Yan,et al."Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats".ADDICTION BIOLOGY 19.1(2014):5-15.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000328610300002.（606KB）	期刊论文	出版稿	暂不开放	CC BY-NC-SA	请求全文