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Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats
Wu, Yan1,2; Li, Yonghui1; Yang, Xiaoyan1; Sui, Nan1
2014
Source PublicationADDICTION BIOLOGY
ISSN1369-1600
SubtypeArticle
Volume19Issue:1Pages:5-15
AbstractPositive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be disrupted by pharmacological treatment. The basolateral amygdala (BLA) has been shown to mediate the reconsolidation of drug-related appetitive memory, but its role in withdrawal-related aversive memory remains elusive. The present study used conditioned place preference (CPP) and conditioned place aversion (CPA) paradigms to investigate the role of BLA and its noradrenergic receptors in reconsolidation of morphine-associated emotional memory in rats. We found that inhibition of protein synthesis in BLA disrupted the reconsolidation of morphine CPP (m-CPP) and CPA related to morphine withdrawal (m-CPA). A high dose of the -noradrenergic receptor antagonist propranolol (3 mu g) in BLA-impaired reconsolidation of m-CPA but not m-CPP, whereas a low dose (0.3 mu g) was ineffective. In contrast, neither low nor high doses of the -noradrenergic receptor antagonist phentolamine (1 or 10 mu g) blocked the reconsolidation of m-CPP and m-CPA. In addition, infusion of propranolol (3 mu g) into nucleus accumbens after retrieval of either m-CPP or m-CPA did not affect its reconsolidation. The findings indicate that appetitive and aversive addictive memories share common neural substrates in BLA, but the specific neurotransmitter mechanism on reconsolidation of morphine-associated negative and positive memories can be dissociable.
KeywordAppetitive and aversive memory basolateral amygdala morphine noradrenergic receptors place conditioning reconsolidation
Indexed BySCI
Language英语
WOS IDWOS:000328610300002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/13441
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wu, Yan,Li, Yonghui,Yang, Xiaoyan,et al. Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats[J]. ADDICTION BIOLOGY,2014,19(1):5-15.
APA Wu, Yan,Li, Yonghui,Yang, Xiaoyan,&Sui, Nan.(2014).Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats.ADDICTION BIOLOGY,19(1),5-15.
MLA Wu, Yan,et al."Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats".ADDICTION BIOLOGY 19.1(2014):5-15.
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